F9URK4 · F9URK4_LACPL
- ProteinN5-carboxyaminoimidazole ribonucleotide synthase
- GenepurK1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids376 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO3- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO3- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
Catalytic activity
- 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + hydrogencarbonate + ATP = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + phosphate + 2 H+
Cofactor
Protein has several cofactor binding sites:
Pathway
Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 111 | ATP (UniProtKB | ChEBI) | |||
Binding site | 151 | ATP (UniProtKB | ChEBI) | |||
Binding site | 156-162 | ATP (UniProtKB | ChEBI) | |||
Binding site | 193 | ATP (UniProtKB | ChEBI) | |||
Binding site | 216 | ATP (UniProtKB | ChEBI) | |||
Binding site | 270-271 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 5-(carboxyamino)imidazole ribonucleotide synthase activity | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | phosphoribosylaminoimidazole carboxylase activity | |
Biological Process | 'de novo' IMP biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameN5-carboxyaminoimidazole ribonucleotide synthase
- EC number
- Short namesN5-CAIR synthase
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageBacteria > Bacillota > Bacilli > Lactobacillales > Lactobacillaceae > Lactiplantibacillus
Accessions
- Primary accessionF9URK4
Proteomes
Interaction
Structure
Sequence
- Sequence statusComplete
- Length376
- Mass (Da)40,503
- Last updated2011-10-19 v1
- ChecksumFC3B974763F63621
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL935263 EMBL· GenBank· DDBJ | CCC79843.1 EMBL· GenBank· DDBJ | Genomic DNA |