F9URK4 · F9URK4_LACPL

Function

function

Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO3- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO3- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site111ATP (UniProtKB | ChEBI)
Binding site151ATP (UniProtKB | ChEBI)
Binding site156-162ATP (UniProtKB | ChEBI)
Binding site193ATP (UniProtKB | ChEBI)
Binding site216ATP (UniProtKB | ChEBI)
Binding site270-271ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function5-(carboxyamino)imidazole ribonucleotide synthase activity
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionphosphoribosylaminoimidazole carboxylase activity
Biological Process'de novo' IMP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    N5-carboxyaminoimidazole ribonucleotide synthase
  • EC number
  • Short names
    N5-CAIR synthase
  • Alternative names
    • 5-(carboxyamino)imidazole ribonucleotide synthetase

Gene names

    • Name
      purK1
    • Synonyms
      purK
    • Ordered locus names
      lp_2728

Organism names

Accessions

  • Primary accession
    F9URK4

Proteomes

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain115-300ATP-grasp

Sequence similarities

Belongs to the PurK/PurT family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    376
  • Mass (Da)
    40,503
  • Last updated
    2011-10-19 v1
  • Checksum
    FC3B974763F63621
MNANFKEALLPPATIGIVGGGQLGQMMTLSAKAMGYRVGVLDPTPKAPAAQVADFQIVAAYDDQAALLDLARRSDVLTYEFENVDENALIAAQAYAKLPQGTALLHITGDRLNEKQFLHDHGIPVTSFAPVTDLQSLNYALNRVGTPAILKTAAGGYDGHGQTDLDTAVVTKAASALLTQPCILEARQKFRTEVSMMVTRSAAGVVTTFPLVENQHQHHILHTTIAPANVQPSVHSAARKIAVSIAESLELRGVLGIEFFVLPDDTLLVNELAPRPHNSGHYTIEACNISQFEAHIRSICGLPIPAITQTSPAVMRNLLGDDLTVARQQLVEHPEWHFHDYGKAAIKPQRKMGHVTVLNHDIDAALASLANLKGEQ

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL935263
EMBL· GenBank· DDBJ
CCC79843.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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