F9URK2 · F9URK2_LACPL

Function

function

Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

Catalytic activity

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide: step 1/2.

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionphosphoribosylformylglycinamidine synthase activity
Biological Process'de novo' IMP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoribosylformylglycinamidine synthase subunit PurS
  • EC number
  • Short names
    FGAM synthase
  • Alternative names
    • Formylglycinamide ribonucleotide amidotransferase subunit III
      (FGAR amidotransferase III
      ; FGAR-AT III
      )
    • Phosphoribosylformylglycinamidine synthase subunit III

Gene names

    • Name
      purS
    • Ordered locus names
      lp_2726

Organism names

Accessions

  • Primary accession
    F9URK2

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the PurS family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    84
  • Mass (Da)
    9,754
  • Last updated
    2011-10-19 v1
  • Checksum
    03285ACC249D2604
MYLVKIYVTYKQSILDPKGEAIHDALHRLGYTNVDAVELGKYFEVKIHADDRPVAAEIDEMCDRLLANVNMETYRYEITEMEAL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL935263
EMBL· GenBank· DDBJ
CCC79841.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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