F9NS85 · F9NS85_9ACTN
- Protein4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)
- GeneispG
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids435 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
Catalytic activity
- (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + oxidized [flavodoxin] + H2O + 2 H+ = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]
Cofactor
Note: Binds 1 [4Fe-4S] cluster.
Pathway
Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 5/6.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 335 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
Binding site | 338 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
Binding site | 370 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
Binding site | 377 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity (ferredoxin) | |
Molecular Function | 4-hydroxy-3-methylbut-2-enyl-diphosphate synthase activity (flavodoxin) | |
Molecular Function | iron ion binding | |
Biological Process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway | |
Biological Process | terpenoid biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Propionibacteriales > Propionibacteriaceae > Cutibacterium
Accessions
- Primary accessionF9NS85
Proteomes
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 18-44 | Disordered | |||
Compositional bias | 19-44 | Basic and acidic residues | |||
Sequence similarities
Belongs to the IspG family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length435
- Mass (Da)46,272
- Last updated2011-10-19 v1
- Checksum543C04779153DA26
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 19-44 | Basic and acidic residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AFUN01000004 EMBL· GenBank· DDBJ | EGR98171.1 EMBL· GenBank· DDBJ | Genomic DNA |