F9NS73 · F9NS73_9ACTN

Function

function

Catalyzes the reversible phosphorylation of UMP to UDP.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Activity regulation

Inhibited by UTP.

Pathway

Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site11-14ATP (UniProtKB | ChEBI)
Binding site52UMP (UniProtKB | ChEBI)
Binding site53ATP (UniProtKB | ChEBI)
Binding site57ATP (UniProtKB | ChEBI)
Binding site72UMP (UniProtKB | ChEBI)
Binding site133-140UMP (UniProtKB | ChEBI)
Binding site161ATP (UniProtKB | ChEBI)
Binding site167ATP (UniProtKB | ChEBI)
Binding site170ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular FunctionUMP kinase activity
Biological Process'de novo' CTP biosynthetic process
Biological Processphosphorylation
Biological ProcessUDP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Uridylate kinase
  • EC number
  • Short names
    UK
  • Alternative names
    • Uridine monophosphate kinase
      (UMP kinase
      ; UMPK
      )

Gene names

    • Name
      pyrH
    • ORF names
      HMPREF1162_0875

Organism names

Accessions

  • Primary accession
    F9NS73

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homohexamer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain6-215Aspartate/glutamate/uridylate kinase

Sequence similarities

Belongs to the UMP kinase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    237
  • Mass (Da)
    25,565
  • Last updated
    2011-10-19 v1
  • Checksum
    77DA310529FCE968
MPERYNRVLLKLSGEVFGGGGVGVDADVVSAKAREIAEIANSGVQVAVVVGGGNFFRGAELQQHGMQRDRADYMGMLGTVMNCLALQDFCEKAGVDTRVQTAITMGQVAEPYIPRKAERHMEKGRVVIFGAGSGMPYFSTDTVAAQRALEIGADALLMGKQGVDGVYDSDPKTNPNAYKFDELTYDEFLSRDLKVADATAVAMARDNDLTMVFFNLEMPGNIGRVINGEDIGTTVHR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AFUN01000004
EMBL· GenBank· DDBJ
EGR98179.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help