F8WJL1 · F8WJL1_MOUSE
- ProteinVoltage-dependent L-type calcium channel subunit alpha
- GeneCacna1c
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids2139 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group.
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 363 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 706 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 1115 | Ca2+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | dendrite | |
Cellular Component | perikaryon | |
Cellular Component | postsynaptic density membrane | |
Cellular Component | T-tubule | |
Cellular Component | voltage-gated calcium channel complex | |
Molecular Function | metal ion binding | |
Molecular Function | voltage-gated calcium channel activity | |
Biological Process | system process |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameVoltage-dependent L-type calcium channel subunit alpha
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionF8WJL1
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane, sarcolemma ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 128-145 | Helical | |||
Transmembrane | 165-185 | Helical | |||
Transmembrane | 197-215 | Helical | |||
Transmembrane | 268-290 | Helical | |||
Transmembrane | 349-370 | Helical | |||
Transmembrane | 382-404 | Helical | |||
Transmembrane | 525-542 | Helical | |||
Transmembrane | 562-585 | Helical | |||
Transmembrane | 654-673 | Helical | |||
Transmembrane | 726-753 | Helical | |||
Transmembrane | 896-918 | Helical | |||
Transmembrane | 938-959 | Helical | |||
Transmembrane | 971-997 | Helical | |||
Transmembrane | 1017-1046 | Helical | |||
Transmembrane | 1142-1169 | Helical | |||
Transmembrane | 1220-1241 | Helical | |||
Transmembrane | 1253-1273 | Helical | |||
Transmembrane | 1359-1377 | Helical | |||
Transmembrane | 1453-1476 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for glycosylation.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Glycosylation | 328 | N-linked (GlcNAc...) asparagine | |||
Keywords
- PTM
Expression
Gene expression databases
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-20 | Disordered | |||
Region | 73-98 | Disordered | |||
Region | 449-481 | Disordered | |||
Compositional bias | 764-809 | Basic and acidic residues | |||
Region | 764-861 | Disordered | |||
Compositional bias | 826-842 | Basic and acidic residues | |||
Domain | 1610-1644 | Voltage-dependent calcium channel alpha-1 subunit IQ | |||
Region | 1732-1773 | Disordered | |||
Region | 1940-1966 | Disordered | |||
Compositional bias | 1947-1962 | Pro residues | |||
Sequence similarities
Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1C subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,139
- Mass (Da)240,113
- Last updated2014-10-29 v2
- MD5 ChecksumDBB6863C754E2CD67D48EF0971A6FCCC
Computationally mapped potential isoform sequences
There are 20 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q01815 | CAC1C_MOUSE | Cacna1c | 2139 | ||
A0A668KLV2 | A0A668KLV2_MOUSE | Cacna1c | 255 | ||
A0A1W2P6T3 | A0A1W2P6T3_MOUSE | Cacna1c | 1969 | ||
A0A1W2P6Z7 | A0A1W2P6Z7_MOUSE | Cacna1c | 2005 | ||
A0A1W2P731 | A0A1W2P731_MOUSE | Cacna1c | 2063 | ||
C7TQ57 | C7TQ57_MOUSE | Cacna1c | 2169 | ||
C7TQ59 | C7TQ59_MOUSE | Cacna1c | 2169 | ||
A0A1W2P805 | A0A1W2P805_MOUSE | Cacna1c | 1980 | ||
A0A087WPP1 | A0A087WPP1_MOUSE | Cacna1c | 2167 | ||
A0A087WPZ8 | A0A087WPZ8_MOUSE | Cacna1c | 2139 | ||
A0A087WR02 | A0A087WR02_MOUSE | Cacna1c | 2139 | ||
A0A087WQJ4 | A0A087WQJ4_MOUSE | Cacna1c | 2156 | ||
A0A087WQT9 | A0A087WQT9_MOUSE | Cacna1c | 2135 | ||
A0A087WS40 | A0A087WS40_MOUSE | Cacna1c | 2153 | ||
A0A087WS67 | A0A087WS67_MOUSE | Cacna1c | 2164 | ||
A0A087WRM3 | A0A087WRM3_MOUSE | Cacna1c | 2187 | ||
A0A087WSE7 | A0A087WSE7_MOUSE | Cacna1c | 2194 | ||
A0A087WRZ6 | A0A087WRZ6_MOUSE | Cacna1c | 2159 | ||
Q0PCR6 | Q0PCR6_MOUSE | Cacna1c | 2169 | ||
F7C376 | F7C376_MOUSE | Cacna1c | 2222 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 764-809 | Basic and acidic residues | |||
Compositional bias | 826-842 | Basic and acidic residues | |||
Compositional bias | 1947-1962 | Pro residues | |||
Keywords
- Technical term