F8WJL1 · F8WJL1_MOUSE

  • Protein
    Voltage-dependent L-type calcium channel subunit alpha
  • Gene
    Cacna1c
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group.
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.

Features

Showing features for binding site.

121392004006008001,0001,2001,4001,6001,8002,000
TypeIDPosition(s)Description
Binding site363Ca2+ (UniProtKB | ChEBI)
Binding site706Ca2+ (UniProtKB | ChEBI)
Binding site1115Ca2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentdendrite
Cellular Componentperikaryon
Cellular Componentpostsynaptic density membrane
Cellular ComponentT-tubule
Cellular Componentvoltage-gated calcium channel complex
Molecular Functionmetal ion binding
Molecular Functionvoltage-gated calcium channel activity
Biological Processsystem process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Voltage-dependent L-type calcium channel subunit alpha

Gene names

    • Name
      Cacna1c

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    F8WJL1

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane, sarcolemma
; Multi-pass membrane protein
Cell projection, dendrite
Membrane
; Multi-pass membrane protein
Perikaryon
Postsynaptic density membrane

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane128-145Helical
Transmembrane165-185Helical
Transmembrane197-215Helical
Transmembrane268-290Helical
Transmembrane349-370Helical
Transmembrane382-404Helical
Transmembrane525-542Helical
Transmembrane562-585Helical
Transmembrane654-673Helical
Transmembrane726-753Helical
Transmembrane896-918Helical
Transmembrane938-959Helical
Transmembrane971-997Helical
Transmembrane1017-1046Helical
Transmembrane1142-1169Helical
Transmembrane1220-1241Helical
Transmembrane1253-1273Helical
Transmembrane1359-1377Helical
Transmembrane1453-1476Helical

Keywords

PTM/Processing

Features

Showing features for glycosylation.

TypeIDPosition(s)Description
Glycosylation328N-linked (GlcNAc...) asparagine

Keywords

Expression

Gene expression databases

Structure

3D structure databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region1-20Disordered
Region73-98Disordered
Region449-481Disordered
Compositional bias764-809Basic and acidic residues
Region764-861Disordered
Compositional bias826-842Basic and acidic residues
Domain1610-1644Voltage-dependent calcium channel alpha-1 subunit IQ
Region1732-1773Disordered
Region1940-1966Disordered
Compositional bias1947-1962Pro residues

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,139
  • Mass (Da)
    240,113
  • Last updated
    2014-10-29 v2
  • MD5 Checksum
    DBB6863C754E2CD67D48EF0971A6FCCC
MVNENTRMYVPEENHQGSNYGSPRPAHANMNANAAAGLAPEHIPTPGAALSWQAAIDAARQAKLMGSAGNATISTVSSTQRKRQQYGKPKKQGGTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIIDVPAEEDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEDKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPHWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFIVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQEVMEKPAVEESKEEKIELKSITADGESPPTTKINMDDLQPSENEDKSPHSNPDTAGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSPNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVHPAEHTQCSPSMSAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVTYYQSDSRGNFPQTFATQRPLHINKTGNNQADTESPSHEKLVDSTFTPSSYSSTGSNANINNANNTALGRFPHPAGYSSTVSTVEGHGPPLSPAVRVQEAAWKLSSKRCHSRESQGATVNQEIFPDETRSVRMSEEAEYCSEPSLLSTDMFSYQEDEHRQLTCPEEDKREIQPSPKRSFLRSASLGRRASFHLECLKRQKDQGGDISQKTALPLHLVHHQALAVAGLSPLLQRSHSPTTFPRPCPTPPVTPGSRGRPLRPIPTLRLEGAESSEKLNSSFPSIHCSSWSEETTACSGSSSMARRARPVSLTVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMENAADNILSGGAQQSPNGTLLPFVNCRDPGQDRAVAPEDESCAYALGRGRSEEALADSRSYVSNL

Computationally mapped potential isoform sequences

There are 20 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q01815CAC1C_MOUSECacna1c2139
A0A668KLV2A0A668KLV2_MOUSECacna1c255
A0A1W2P6T3A0A1W2P6T3_MOUSECacna1c1969
A0A1W2P6Z7A0A1W2P6Z7_MOUSECacna1c2005
A0A1W2P731A0A1W2P731_MOUSECacna1c2063
C7TQ57C7TQ57_MOUSECacna1c2169
C7TQ59C7TQ59_MOUSECacna1c2169
A0A1W2P805A0A1W2P805_MOUSECacna1c1980
A0A087WPP1A0A087WPP1_MOUSECacna1c2167
A0A087WPZ8A0A087WPZ8_MOUSECacna1c2139
A0A087WR02A0A087WR02_MOUSECacna1c2139
A0A087WQJ4A0A087WQJ4_MOUSECacna1c2156
A0A087WQT9A0A087WQT9_MOUSECacna1c2135
A0A087WS40A0A087WS40_MOUSECacna1c2153
A0A087WS67A0A087WS67_MOUSECacna1c2164
A0A087WRM3A0A087WRM3_MOUSECacna1c2187
A0A087WSE7A0A087WSE7_MOUSECacna1c2194
A0A087WRZ6A0A087WRZ6_MOUSECacna1c2159
Q0PCR6Q0PCR6_MOUSECacna1c2169
F7C376F7C376_MOUSECacna1c2222

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias764-809Basic and acidic residues
Compositional bias826-842Basic and acidic residues
Compositional bias1947-1962Pro residues

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

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