F8WD41 · F8WD41_HUMAN
- ProteinParaoxonase
- GenePON3
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids270 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
Catalytic activity
- a phenyl acetate + H2O = a phenol + acetate + H+
Cofactor
Note: Binds 2 calcium ions per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 53 | Ca2+ 1 (UniProtKB | ChEBI); catalytic | ||||
Sequence: E | ||||||
Binding site | 54 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Active site | 114 | Proton acceptor | ||||
Sequence: H | ||||||
Binding site | 116 | Ca2+ 1 (UniProtKB | ChEBI); catalytic | ||||
Sequence: I | ||||||
Binding site | 167 | Ca2+ 1 (UniProtKB | ChEBI); catalytic | ||||
Sequence: N | ||||||
Binding site | 168 | Ca2+ 1 (UniProtKB | ChEBI); catalytic | ||||
Sequence: D | ||||||
Binding site | 223 | Ca2+ 1 (UniProtKB | ChEBI); catalytic | ||||
Sequence: N |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | acyl-L-homoserine-lactone lactonohydrolase activity | |
Molecular Function | arylesterase activity | |
Molecular Function | metal ion binding |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameParaoxonase
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionF8WD41
Proteomes
Organism-specific databases
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 112 variants from UniProt as well as other sources including ClinVar and dbSNP.
Genetic variation databases
PTM/Processing
Expression
Gene expression databases
Structure
Sequence
- Sequence statusComplete
- Length270
- Mass (Da)30,739
- Last updated2011-09-21 v1
- Checksum41F0481EB3C84079
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC004022 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC005021 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |