F8WAI0 · F8WAI0_HUMAN

  • Protein
    Spectrin repeat containing nuclear envelope protein 1
  • Gene
    SYNE1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    2/5

Function

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnuclear membrane
Cellular Componentnucleoplasm

Names & Taxonomy

Protein names

  • Submitted names
    • Spectrin repeat containing nuclear envelope protein 1

Gene names

    • Name
      SYNE1

Organism names

Accessions

  • Primary accession
    F8WAI0

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain.

TypeIDPosition(s)Description
Topological domain1-924Cytoplasmic
Topological domain946-975Perinuclear space

Keywords

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 1,303 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Genetic variation databases

PTM/Processing

Features

Showing features for modified residue (large scale data).

TypeIDPosition(s)SourceDescription
Modified residue (large scale data)378PRIDEPhosphoserine
Modified residue (large scale data)405PRIDEPhosphoserine
Modified residue (large scale data)413PRIDEPhosphoserine
Modified residue (large scale data)425PRIDEPhosphoserine
Modified residue (large scale data)429PRIDEPhosphothreonine
Modified residue (large scale data)432PRIDEPhosphoserine
Modified residue (large scale data)435PRIDEPhosphoserine
Modified residue (large scale data)460PRIDEPhosphoserine
Modified residue (large scale data)487PRIDEPhosphoserine
Modified residue (large scale data)503PRIDEPhosphoserine
Modified residue (large scale data)536PRIDEPhosphoserine
Modified residue (large scale data)538PRIDEPhosphothreonine
Modified residue (large scale data)540PRIDEPhosphothreonine
Modified residue (large scale data)564PRIDEPhosphoserine
Modified residue (large scale data)882PRIDEPhosphoserine
Modified residue (large scale data)902PRIDEPhosphoserine
Modified residue (large scale data)904PRIDEPhosphoserine
Modified residue (large scale data)905PRIDEPhosphoserine

Keywords

Proteomic databases

Expression

Gene expression databases

Structure

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region401-436Disordered
Compositional bias402-422Polar residues
Compositional bias849-909Polar residues
Region849-912Disordered
Domain916-975KASH

Sequence similarities

Belongs to the nesprin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    975
  • Mass (Da)
    111,386
  • Last updated
    2011-09-21 v1
  • Checksum
    29A7016391C0C3F0
MVVAEDLSALRMAEDSCVDADLPDCNCDVTRVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCALSNNFARSFHPMLRYTNGPPPL

Computationally mapped potential isoform sequences

There are 25 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q8NF91SYNE1_HUMANSYNE18797
H0YGD3H0YGD3_HUMANSYNE1207
H0YFT4H0YFT4_HUMANSYNE162
B7Z9Y6B7Z9Y6_HUMANSYNE1911
Q5JV20Q5JV20_HUMANSYNE1952
H0Y325H0Y325_HUMANSYNE11654
H0Y326H0Y326_HUMANSYNE11355
A0A5F9ZH00A0A5F9ZH00_HUMANSYNE136
A0A5F9ZHI3A0A5F9ZHI3_HUMANSYNE1542
A0A5F9ZHR3A0A5F9ZHR3_HUMANSYNE11424
A0A5F9ZI52A0A5F9ZI52_HUMANSYNE11528
A0A5F9ZH86A0A5F9ZH86_HUMANSYNE1510
A0A5F9ZH87A0A5F9ZH87_HUMANSYNE1542
A0A5F9ZHB2A0A5F9ZHB2_HUMANSYNE1591
A0A5F9ZHD7A0A5F9ZHD7_HUMANSYNE1752
A0A5F9ZHE1A0A5F9ZHE1_HUMANSYNE1635
I6XKI8I6XKI8_HUMANSYNE1494
F5GZ83F5GZ83_HUMANSYNE1195
F5GXQ8F5GXQ8_HUMANSYNE11433
F5GYQ7F5GYQ7_HUMANSYNE1615
F5H6R8F5H6R8_HUMANSYNE1242
F5H4Q0F5H4Q0_HUMANSYNE1754
F5H422F5H422_HUMANSYNE1612
A0A0C4DH48A0A0C4DH48_HUMANSYNE1511
A0A0C4DG40A0A0C4DG40_HUMANSYNE18749

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias402-422Polar residues
Compositional bias849-909Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL049548
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL078582
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL136079
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL138832
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL357081
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL450401
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL589963
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL591507
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
KF458330
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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