F8WAI0 · F8WAI0_HUMAN
- ProteinSpectrin repeat containing nuclear envelope protein 1
- GeneSYNE1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids975 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nuclear membrane | |
Cellular Component | nucleoplasm |
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Organism
- Taxonomic lineagecellular organisms > Eukaryota (eucaryotes) > Opisthokonta > Metazoa (metazoans) > Eumetazoa > Bilateria > Deuterostomia > Chordata (chordates) > Craniata > Vertebrata (vertebrates) > Gnathostomata (jawed vertebrates) > Teleostomi > Euteleostomi (bony vertebrates) > Sarcopterygii > Dipnotetrapodomorpha > Tetrapoda (tetrapods) > Amniota (amniotes) > Mammalia (mammals) > Theria > Eutheria (placentals) > Boreoeutheria > Euarchontoglires > Primates > Haplorrhini > Simiiformes > Catarrhini > Hominoidea (apes) > Hominidae (great apes) > Homininae > Homo
Accessions
- Primary accessionF8WAI0
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Features
Showing features for topological domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-924 | Cytoplasmic | ||||
Sequence: MVVAEDLSALRMAEDSCVDADLPDCNCDVTRVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVLR | ||||||
Topological domain | 946-975 | Perinuclear space | ||||
Sequence: SEEDYSCALSNNFARSFHPMLRYTNGPPPL |
Keywords
- Cellular component
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1,303 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Genetic variation databases
PTM/Processing
Features
Showing features for modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Modified residue (large scale data) | 378 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 405 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 413 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 425 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 429 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 432 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 435 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 460 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 487 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 503 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 536 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 538 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 540 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 564 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 882 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 902 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 904 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 905 | PRIDE | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 401-436 | Disordered | ||||
Sequence: DSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSI | ||||||
Compositional bias | 402-422 | Polar residues | ||||
Sequence: SLLSPQPSSNLSLSLAQPLRS | ||||||
Compositional bias | 849-909 | Polar residues | ||||
Sequence: SWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSSLSEP | ||||||
Region | 849-912 | Disordered | ||||
Sequence: SWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPG | ||||||
Domain | 916-975 | KASH | ||||
Sequence: RGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCALSNNFARSFHPMLRYTNGPPPL |
Sequence similarities
Belongs to the nesprin family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length975
- Mass (Da)111,386
- Last updated2011-09-21 v1
- Checksum29A7016391C0C3F0
Computationally mapped potential isoform sequences
There are 25 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q8NF91 | SYNE1_HUMAN | SYNE1 | 8797 | ||
H0YGD3 | H0YGD3_HUMAN | SYNE1 | 207 | ||
H0YFT4 | H0YFT4_HUMAN | SYNE1 | 62 | ||
B7Z9Y6 | B7Z9Y6_HUMAN | SYNE1 | 911 | ||
Q5JV20 | Q5JV20_HUMAN | SYNE1 | 952 | ||
H0Y325 | H0Y325_HUMAN | SYNE1 | 1654 | ||
H0Y326 | H0Y326_HUMAN | SYNE1 | 1355 | ||
A0A5F9ZH00 | A0A5F9ZH00_HUMAN | SYNE1 | 36 | ||
A0A5F9ZHI3 | A0A5F9ZHI3_HUMAN | SYNE1 | 542 | ||
A0A5F9ZHR3 | A0A5F9ZHR3_HUMAN | SYNE1 | 1424 | ||
A0A5F9ZI52 | A0A5F9ZI52_HUMAN | SYNE1 | 1528 | ||
A0A5F9ZH86 | A0A5F9ZH86_HUMAN | SYNE1 | 510 | ||
A0A5F9ZH87 | A0A5F9ZH87_HUMAN | SYNE1 | 542 | ||
A0A5F9ZHB2 | A0A5F9ZHB2_HUMAN | SYNE1 | 591 | ||
A0A5F9ZHD7 | A0A5F9ZHD7_HUMAN | SYNE1 | 752 | ||
A0A5F9ZHE1 | A0A5F9ZHE1_HUMAN | SYNE1 | 635 | ||
I6XKI8 | I6XKI8_HUMAN | SYNE1 | 494 | ||
F5GZ83 | F5GZ83_HUMAN | SYNE1 | 195 | ||
F5GXQ8 | F5GXQ8_HUMAN | SYNE1 | 1433 | ||
F5GYQ7 | F5GYQ7_HUMAN | SYNE1 | 615 | ||
F5H6R8 | F5H6R8_HUMAN | SYNE1 | 242 | ||
F5H4Q0 | F5H4Q0_HUMAN | SYNE1 | 754 | ||
F5H422 | F5H422_HUMAN | SYNE1 | 612 | ||
A0A0C4DH48 | A0A0C4DH48_HUMAN | SYNE1 | 511 | ||
A0A0C4DG40 | A0A0C4DG40_HUMAN | SYNE1 | 8749 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 402-422 | Polar residues | ||||
Sequence: SLLSPQPSSNLSLSLAQPLRS | ||||||
Compositional bias | 849-909 | Polar residues | ||||
Sequence: SWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSSLSEP |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL049548 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL078582 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL136079 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL138832 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL357081 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL450401 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL589963 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL591507 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
KF458330 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |