F8W8R6 · F8W8R6_HUMAN
- Protein[histone H3]-trimethyl-L-lysine(27) demethylase
- GeneKDM6A
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1408 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
Catalytic activity
- 2 2-oxoglutarate + N6,N6,N6-trimethyl-L-lysyl27-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N6-methyl-L-lysyl27-[histone H3] + 2 succinate
2 CHEBI:16810 + RHEA-COMP:15535 CHEBI:61961 Position: 27+ 2 CHEBI:15379 = 2 CHEBI:16526 + 2 CHEBI:16842 + RHEA-COMP:15544 CHEBI:61929 Position: 27+ 2 CHEBI:30031
Cofactor
Protein has several cofactor binding sites:
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | histone demethylase activity | |
Molecular Function | metal ion binding | |
Molecular Function | oxidoreductase activity |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name[histone H3]-trimethyl-L-lysine(27) demethylase
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionF8W8R6
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 4,226 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Genetic variation databases
PTM/Processing
Features
Showing features for modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Modified residue (large scale data) | 768 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 776 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 824 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 825 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 834 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 836 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1068 | PRIDE | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
Expression
Gene expression databases
Family & Domains
Features
Showing features for repeat, region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Repeat | 130-163 | TPR | ||||
Sequence: AAFLYGLGLVYFHYNAFQWAIKAFQEVLYVDPSF | ||||||
Repeat | 318-351 | TPR | ||||
Sequence: ADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGH | ||||||
Region | 430-471 | Disordered | ||||
Sequence: SSQVDDLSSPAKRKRTSSPTKNTSDNWSGGHAVSHPPVQQQA | ||||||
Region | 631-753 | Disordered | ||||
Sequence: LTSSAEEPWKNQLSNSTQGLHKGQSSHSAGPNGERPLSSTGPSQHLQAAGSGIQNQNGHPTLPSNSVTQGAALNHLSSHTATSGGQQGITLTKESKPSGNILTVPETSRHTGETPNSTASVEG | ||||||
Region | 765-785 | Disordered | ||||
Sequence: AVCSPSHGDSKSPGLLSSDNP | ||||||
Compositional bias | 817-869 | Polar residues | ||||
Sequence: KTDNSVASSPSSAISTATPSPKSTEQTTTNSVTSLNSPHSGLHTINGEGMEES | ||||||
Region | 817-871 | Disordered | ||||
Sequence: KTDNSVASSPSSAISTATPSPKSTEQTTTNSVTSLNSPHSGLHTINGEGMEESQS | ||||||
Region | 921-947 | Disordered | ||||
Sequence: LLDKCPPPRPPSSPYPPLPKDKLNPPT | ||||||
Compositional bias | 924-944 | Pro residues | ||||
Sequence: KCPPPRPPSSPYPPLPKDKLN | ||||||
Region | 1050-1086 | Disordered | ||||
Sequence: FQESLREENEKRSHHKDHSDSESTSSDNSGRRRKGPF | ||||||
Compositional bias | 1053-1083 | Basic and acidic residues | ||||
Sequence: SLREENEKRSHHKDHSDSESTSSDNSGRRRK | ||||||
Domain | 1102-1265 | JmjC | ||||
Sequence: KWKLQLHELTKLPAFVRVVSAGNLLSHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFVVPEGYWGVLNDFCEKNNLNFLMGSWWPNLEDLYEANVPVYRFIQRPGDLVWINAGTVHWVQAIGWCNNIAWNVGPLTACQYKLAVERYEW |
Sequence similarities
Belongs to the UTX family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,408
- Mass (Da)154,928
- Last updated2020-12-02 v3
- Checksum12E2DA673F80E91F
Computationally mapped potential isoform sequences
There are 18 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
O15550 | KDM6A_HUMAN | KDM6A | 1401 | ||
A0A6Q8PFK0 | A0A6Q8PFK0_HUMAN | KDM6A | 1367 | ||
A0A6Q8PFD0 | A0A6Q8PFD0_HUMAN | KDM6A | 1256 | ||
A0A6Q8PG92 | A0A6Q8PG92_HUMAN | KDM6A | 1293 | ||
A0A6Q8PG32 | A0A6Q8PG32_HUMAN | KDM6A | 1355 | ||
A0A6Q8PGN0 | A0A6Q8PGN0_HUMAN | KDM6A | 1336 | ||
A0A6Q8PGG6 | A0A6Q8PGG6_HUMAN | KDM6A | 151 | ||
A0A6Q8PH94 | A0A6Q8PH94_HUMAN | KDM6A | 126 | ||
A0A6Q8PHJ0 | A0A6Q8PHJ0_HUMAN | KDM6A | 1129 | ||
A0A6Q8PHB6 | A0A6Q8PHB6_HUMAN | KDM6A | 1427 | ||
H0Y6V5 | H0Y6V5_HUMAN | KDM6A | 161 | ||
A0A804HIZ7 | A0A804HIZ7_HUMAN | KDM6A | 142 | ||
A0A804HLJ3 | A0A804HLJ3_HUMAN | KDM6A | 842 | ||
A0A804HJA2 | A0A804HJA2_HUMAN | KDM6A | 1374 | ||
A0A087X0R0 | A0A087X0R0_HUMAN | KDM6A | 1453 | ||
A0A087WUN6 | A0A087WUN6_HUMAN | KDM6A | 224 | ||
F5H6S1 | F5H6S1_HUMAN | KDM6A | 1356 | ||
F5H5V6 | F5H5V6_HUMAN | KDM6A | 1322 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 817-869 | Polar residues | ||||
Sequence: KTDNSVASSPSSAISTATPSPKSTEQTTTNSVTSLNSPHSGLHTINGEGMEES | ||||||
Compositional bias | 924-944 | Pro residues | ||||
Sequence: KCPPPRPPSSPYPPLPKDKLN | ||||||
Compositional bias | 1053-1083 | Basic and acidic residues | ||||
Sequence: SLREENEKRSHHKDHSDSESTSSDNSGRRRK |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC136488 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL133545 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL138744 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
KF510678 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |