F8W289 · F8W289_DANRE
- ProteinGalactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase
- Geneb3gat3
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids330 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H+ + UDP
Cofactor
Pathway
Protein modification; protein glycosylation.
Features
Showing features for binding site, site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 79-81 | UDP-alpha-D-glucuronate (UniProtKB | ChEBI) | ||||
Sequence: PTY | ||||||
Binding site | 110 | UDP-alpha-D-glucuronate (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 153 | UDP-alpha-D-glucuronate (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 158 | UDP-alpha-D-glucuronate (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 189-191 | UDP-alpha-D-glucuronate (UniProtKB | ChEBI) | ||||
Sequence: DDD | ||||||
Binding site | 191 | Mn2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Site | 222 | Interaction with galactose moiety of substrate glycoprotein | ||||
Sequence: E | ||||||
Active site | 276 | Proton donor/acceptor | ||||
Sequence: E | ||||||
Binding site | 303-305 | UDP-alpha-D-glucuronate (UniProtKB | ChEBI) | ||||
Sequence: HTR |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | Golgi membrane | |
Molecular Function | galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity | |
Molecular Function | metal ion binding | |
Biological Process | carbohydrate metabolic process | |
Biological Process | cartilage development | |
Biological Process | chondroitin sulfate proteoglycan biosynthetic process | |
Biological Process | extracellular matrix organization | |
Biological Process | heparan sulfate proteoglycan biosynthetic process | |
Biological Process | protein glycosylation | |
Biological Process | proteoglycan biosynthetic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGalactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionF8W289
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Golgi apparatus membrane ; Single-pass type II membrane protein
Keywords
- Cellular component
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Disulfide bond | 35 | Interchain | ||||
Sequence: C |
Keywords
- PTM
Proteomic databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Coiled coil | 39-66 | |||||
Sequence: EQSKDQQISQLKGELQKLQEHIKTSELS |
Sequence similarities
Belongs to the glycosyltransferase 43 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length330
- Mass (Da)38,110
- Last updated2011-09-21 v1
- Checksum698B8BF4BE29156C
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL954715 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BX547932 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CU856512 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |