Endothelial EGLN3-PKM2 signaling induces the formation of acute astrocytic barrier to alleviate immune cell infiltration after subarachnoid hemorrhage.
Low nuclear expression of HIF-hydroxylases PHD2/EGLN1 and PHD3/EGLN3 are associated with poor recurrence-free survival in clear cell renal cell carcinoma.
This is the first crystal report of PHD3/PKM2 complex as well as this study demonstrates a direct physical binding through protein-protein interaction.
The authors did not detect prolyl-hydroxylase activity on any reported non-HIF protein or peptide using conditions supporting robust HIF-alpha hydroxylation.
This study links the oxygen sensor PHD3 to metastasis and drug resistance in cancer with implications for therapeutic improvement by targeting this system.
provides a rationale for targeting the PHD3-mediated regulation of the adaptive cellular hypoxic response in MM and suggests that targeting the O2-sensing pathway alone or in combination with other anti-myeloma chemotherapeutics may have clinical efficacy
These results indicate that the immunohistochemistry analysis of the protein expression of PDK1 PHD3 and HIF-1alpha defines the hypoxic status of Neuroblastoma tumors.
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