Silencing Sik2 further diminished SIRT3 activity and enhanced acetylation of PDHA1 K83 level. Reconstruction of SIRT3 restored PDH activity and thermogenic markers expression in differentiated brown adipocytes from SIRT3 knockout (KO) mice.
The effect of SIK2 on autophagic flux occurs before the regulation of TFEB protein levels suggesting different mechanisms whereby SIK2 stimulates autophagy.
Mutant Gnas is critical for pancreatic tumour tumorigenesis driven by protein-kinase-A-mediated suppression of salt-inducible kinases (Sik1-3) and associated with induction of lipid remodelling and fatty acid oxidation.
SIK-2 participates in inflammation induction after ICH. SIK-2 inhibition via Bosutinib or small interfering RNA decreased inflammation attenuating brain injury. SIK-2 effects are at least partly mediated by CRTC3-cyclic amp-response element binding protein-NF-kappaB signaling pathway.
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