F8VPQ6 · F8VPQ6_MOUSE

  • Protein
    Alkaline phosphatase
  • Gene
    Alpi
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion.
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions.

Features

Showing features for binding site, active site.

155450100150200250300350400450500550
Type
IDPosition(s)Description
Binding site62Mg2+ (UniProtKB | ChEBI)
Binding site62Zn2+ 2 (UniProtKB | ChEBI)
Active site112Phosphoserine intermediate
Binding site173Mg2+ (UniProtKB | ChEBI)
Binding site175Mg2+ (UniProtKB | ChEBI)
Binding site331Mg2+ (UniProtKB | ChEBI)
Binding site336Zn2+ 2 (UniProtKB | ChEBI)
Binding site340Zn2+ 2 (UniProtKB | ChEBI)
Binding site377Zn2+ 2 (UniProtKB | ChEBI)
Binding site378Zn2+ 2 (UniProtKB | ChEBI)
Binding site452Zn2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentextracellular space
Cellular Componentplasma membrane
Cellular Componentside of membrane
Molecular Functionalkaline phosphatase activity
Molecular Functionmetal ion binding
Molecular Functionphosphatase activity
Biological Processcellular response to BMP stimulus
Biological Processcoenzyme A catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Alkaline phosphatase
  • EC number

Gene names

    • Name
      Alpi

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    F8VPQ6

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Lipid-anchor, GPI-anchor

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-20
ChainPRO_500337923121-554Alkaline phosphatase

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Sequence similarities

Belongs to the alkaline phosphatase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    554
  • Mass (Da)
    59,532
  • Last updated
    2011-09-21 v1
  • MD5 Checksum
    02676D45B921C1793A1277F8BCC78101
MQGDWVLLLFLGLRIHLSFGIIPAEEENPAFWNKKAAEALDAAKKLQPIQTSAKNLIIFLGDGMGVPTVTATRILKGQLEGHLGPETPLAMDLFPYMALSKTYNVDRQVPDSAGTATAYLCGVKANYKTIGLSAAARLDQCNTTFGNEVFSVMYRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDAEMPASALQDGCKDIATQLISNMDIDVILGGGRKFMFPKGTPDPEYPSDSNQSGTRLDDQNLVQTWLSKHQGARYVWNRSELIQASQDPAVTHLMGLFEPTEMKYDANRNPSVDPSLAEMTEVAVRMLSRNPQGFYLFVEGGRIDQGHHAGTAYLALTEAVMFDSAIEKASQLTNEKDTLILITADHSHVFAFGGYTLRGTSIFGLAPLKALDDKSYTSILYGNGPGYELKSGNRPNVTEAQSVDPNYKQQAAVPLSSETHGGEDVAIFARGPQAHLVHGVQEQNYIAHVMAFAGCLEPYTDCGLAPPAGQSPVITPGQATTTNNAAGQATTTNNAAGQATVLLSLQLLVSMLLLVGTAMVVS

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

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