F8VPQ6 · F8VPQ6_MOUSE
- ProteinAlkaline phosphatase
- GeneAlpi
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids554 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
Catalytic activity
- a phosphate monoester + H2O = an alcohol + phosphate
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 Mg2+ ion.
Note: Binds 2 Zn2+ ions.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 62 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 62 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Active site | 112 | Phosphoserine intermediate | |||
Binding site | 173 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 175 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 331 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 336 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 340 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 377 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 378 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 452 | Zn2+ 2 (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | extracellular space | |
Cellular Component | plasma membrane | |
Cellular Component | side of membrane | |
Molecular Function | alkaline phosphatase activity | |
Molecular Function | metal ion binding | |
Molecular Function | phosphatase activity | |
Biological Process | cellular response to BMP stimulus | |
Biological Process | coenzyme A catabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAlkaline phosphatase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionF8VPQ6
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-20 | ||||
Chain | PRO_5003379231 | 21-554 | Alkaline phosphatase | ||
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Sequence
- Sequence statusComplete
- Length554
- Mass (Da)59,532
- Last updated2011-09-21 v1
- MD5 Checksum02676D45B921C1793A1277F8BCC78101
Keywords
- Technical term