F8U4T6 · F8U4T6_BUNMU
- ProteinCytochrome c oxidase subunit 1
- GeneCOI
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids219 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out)
4 RHEA-COMP:10350 + CHEBI:15379 + 8 H+ (in)CHEBI:15378= 4 RHEA-COMP:14399 + 2 CHEBI:15377 + 4 H+ (out)CHEBI:15378
Cofactor
Protein has several cofactor binding sites:
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | electron transport coupled proton transport | |
Biological Process | mitochondrial electron transport, cytochrome c to oxygen |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Lepidosauria > Squamata > Bifurcata > Unidentata > Episquamata > Toxicofera > Serpentes > Colubroidea > Elapidae > Bungarinae > Bungarus
Accessions
- Primary accessionF8U4T6
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 42-67 | Helical | ||||
Sequence: VTAHAFIMIFFMVMPIMIGGFGNWLI | ||||||
Transmembrane | 88-110 | Helical | ||||
Sequence: LLPPALLLLLSSSYVEAGAGTGW | ||||||
Transmembrane | 130-155 | Helical | ||||
Sequence: AIFSLHLAGASSILGAINFITTCINM | ||||||
Transmembrane | 167-194 | Helical | ||||
Sequence: LFVWSVLITAIMLLLALPVLAAAVTMLL |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-219 | Cytochrome oxidase subunit I profile | ||||
Sequence: TLYLLFGAWSGLIGACLSILMRMELTQPGSLLGSDQIFNVLVTAHAFIMIFFMVMPIMIGGFGNWLIPLMIGAPDMAFPRMNNMSFWLLPPALLLLLSSSYVEAGAGTGWTVYPPLSGNLVHSGPSVDLAIFSLHLAGASSILGAINFITTCINMKPKSMPMFNIPLFVWSVLITAIMLLLALPVLAAAVTMLLTDRNLNTSFFDPSGGGDPVLFQHLF |
Sequence similarities
Belongs to the heme-copper respiratory oxidase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length219
- Mass (Da)23,612
- Last updated2011-09-21 v1
- Checksum4881A13D9B401D1E
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: T | ||||||
Non-terminal residue | 219 | |||||
Sequence: F |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JF700142 EMBL· GenBank· DDBJ | AEH94098.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JF700143 EMBL· GenBank· DDBJ | AEH94099.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JF700144 EMBL· GenBank· DDBJ | AEH94100.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN833585 EMBL· GenBank· DDBJ | AET37156.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN833586 EMBL· GenBank· DDBJ | AET37157.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN833587 EMBL· GenBank· DDBJ | AET37158.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN833588 EMBL· GenBank· DDBJ | AET37159.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN833589 EMBL· GenBank· DDBJ | AET37160.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN833590 EMBL· GenBank· DDBJ | AET37161.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN833593 EMBL· GenBank· DDBJ | AET37164.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN833594 EMBL· GenBank· DDBJ | AET37165.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN833595 EMBL· GenBank· DDBJ | AET37166.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN833596 EMBL· GenBank· DDBJ | AET37167.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN833597 EMBL· GenBank· DDBJ | AET37168.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN860064 EMBL· GenBank· DDBJ | AET37243.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN860065 EMBL· GenBank· DDBJ | AET37244.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF698925 EMBL· GenBank· DDBJ | AHC30890.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF698926 EMBL· GenBank· DDBJ | AHC30891.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF698927 EMBL· GenBank· DDBJ | AHC30892.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF698928 EMBL· GenBank· DDBJ | AHC30893.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR045930 EMBL· GenBank· DDBJ | ALF07367.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR045932 EMBL· GenBank· DDBJ | ALF07369.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR045933 EMBL· GenBank· DDBJ | ALF07370.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR045934 EMBL· GenBank· DDBJ | ALF07371.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR046053 EMBL· GenBank· DDBJ | ALF07490.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF099661 EMBL· GenBank· DDBJ | ASO75192.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF099662 EMBL· GenBank· DDBJ | ASO75193.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF099663 EMBL· GenBank· DDBJ | ASO75194.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF099664 EMBL· GenBank· DDBJ | ASO75195.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF099665 EMBL· GenBank· DDBJ | ASO75196.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF099666 EMBL· GenBank· DDBJ | ASO75197.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG736833 EMBL· GenBank· DDBJ | AXN94107.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG736834 EMBL· GenBank· DDBJ | AXN94108.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG736835 EMBL· GenBank· DDBJ | AXN94109.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG736836 EMBL· GenBank· DDBJ | AXN94110.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG736837 EMBL· GenBank· DDBJ | AXN94111.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG736838 EMBL· GenBank· DDBJ | AXN94112.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG736839 EMBL· GenBank· DDBJ | AXN94113.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG736840 EMBL· GenBank· DDBJ | AXN94114.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG736841 EMBL· GenBank· DDBJ | AXN94115.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG736842 EMBL· GenBank· DDBJ | AXN94116.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG736843 EMBL· GenBank· DDBJ | AXN94117.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG736844 EMBL· GenBank· DDBJ | AXN94118.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG736845 EMBL· GenBank· DDBJ | AXN94119.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG736846 EMBL· GenBank· DDBJ | AXN94120.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG736847 EMBL· GenBank· DDBJ | AXN94121.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG736848 EMBL· GenBank· DDBJ | AXN94122.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG736849 EMBL· GenBank· DDBJ | AXN94123.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG736850 EMBL· GenBank· DDBJ | AXN94124.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG736851 EMBL· GenBank· DDBJ | AXN94125.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG736852 EMBL· GenBank· DDBJ | AXN94126.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG736853 EMBL· GenBank· DDBJ | AXN94127.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG736854 EMBL· GenBank· DDBJ | AXN94128.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG736855 EMBL· GenBank· DDBJ | AXN94129.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG736856 EMBL· GenBank· DDBJ | AXN94130.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG736857 EMBL· GenBank· DDBJ | AXN94131.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG736858 EMBL· GenBank· DDBJ | AXN94132.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG736859 EMBL· GenBank· DDBJ | AXN94133.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG736860 EMBL· GenBank· DDBJ | AXN94134.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG736861 EMBL· GenBank· DDBJ | AXN94135.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG736862 EMBL· GenBank· DDBJ | AXN94136.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG736863 EMBL· GenBank· DDBJ | AXN94137.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG736864 EMBL· GenBank· DDBJ | AXN94138.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG736865 EMBL· GenBank· DDBJ | AXN94139.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG736866 EMBL· GenBank· DDBJ | AXN94140.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG736867 EMBL· GenBank· DDBJ | AXN94141.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG736868 EMBL· GenBank· DDBJ | AXN94142.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG736869 EMBL· GenBank· DDBJ | AXN94143.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG736870 EMBL· GenBank· DDBJ | AXN94144.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG736871 EMBL· GenBank· DDBJ | AXN94145.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG736872 EMBL· GenBank· DDBJ | AXN94146.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG736873 EMBL· GenBank· DDBJ | AXN94147.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG736874 EMBL· GenBank· DDBJ | AXN94148.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG736875 EMBL· GenBank· DDBJ | AXN94149.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG736876 EMBL· GenBank· DDBJ | AXN94150.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG736877 EMBL· GenBank· DDBJ | AXN94151.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG736878 EMBL· GenBank· DDBJ | AXN94152.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG736879 EMBL· GenBank· DDBJ | AXN94153.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG736880 EMBL· GenBank· DDBJ | AXN94154.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG736881 EMBL· GenBank· DDBJ | AXN94155.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG736882 EMBL· GenBank· DDBJ | AXN94156.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG736883 EMBL· GenBank· DDBJ | AXN94157.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG736884 EMBL· GenBank· DDBJ | AXN94158.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG736885 EMBL· GenBank· DDBJ | AXN94159.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG736886 EMBL· GenBank· DDBJ | AXN94160.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG736887 EMBL· GenBank· DDBJ | AXN94161.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG736888 EMBL· GenBank· DDBJ | AXN94162.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG736889 EMBL· GenBank· DDBJ | AXN94163.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK064595 EMBL· GenBank· DDBJ | QCQ65691.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK064799 EMBL· GenBank· DDBJ | QCQ65895.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK064808 EMBL· GenBank· DDBJ | QCQ65904.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK064887 EMBL· GenBank· DDBJ | QCQ65983.1 EMBL· GenBank· DDBJ | Genomic DNA |