F8U4T6 · F8U4T6_BUNMU

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Cu cation (UniProtKB | Rhea| CHEBI:23378 )

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI
    • Synonyms
      COX1

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strains
    • BM1
    • BM10
    • BM11
    • BM12
    • BM13
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Lepidosauria > Squamata > Bifurcata > Unidentata > Episquamata > Toxicofera > Serpentes > Colubroidea > Elapidae > Bungarinae > Bungarus

Accessions

  • Primary accession
    F8U4T6

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane42-67Helical
Transmembrane88-110Helical
Transmembrane130-155Helical
Transmembrane167-194Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-219Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    219
  • Mass (Da)
    23,612
  • Last updated
    2011-09-21 v1
  • Checksum
    4881A13D9B401D1E
TLYLLFGAWSGLIGACLSILMRMELTQPGSLLGSDQIFNVLVTAHAFIMIFFMVMPIMIGGFGNWLIPLMIGAPDMAFPRMNNMSFWLLPPALLLLLSSSYVEAGAGTGWTVYPPLSGNLVHSGPSVDLAIFSLHLAGASSILGAINFITTCINMKPKSMPMFNIPLFVWSVLITAIMLLLALPVLAAAVTMLLTDRNLNTSFFDPSGGGDPVLFQHLF

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue219

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JF700142
EMBL· GenBank· DDBJ
AEH94098.1
EMBL· GenBank· DDBJ
Genomic DNA
JF700143
EMBL· GenBank· DDBJ
AEH94099.1
EMBL· GenBank· DDBJ
Genomic DNA
JF700144
EMBL· GenBank· DDBJ
AEH94100.1
EMBL· GenBank· DDBJ
Genomic DNA
JN833585
EMBL· GenBank· DDBJ
AET37156.1
EMBL· GenBank· DDBJ
Genomic DNA
JN833586
EMBL· GenBank· DDBJ
AET37157.1
EMBL· GenBank· DDBJ
Genomic DNA
JN833587
EMBL· GenBank· DDBJ
AET37158.1
EMBL· GenBank· DDBJ
Genomic DNA
JN833588
EMBL· GenBank· DDBJ
AET37159.1
EMBL· GenBank· DDBJ
Genomic DNA
JN833589
EMBL· GenBank· DDBJ
AET37160.1
EMBL· GenBank· DDBJ
Genomic DNA
JN833590
EMBL· GenBank· DDBJ
AET37161.1
EMBL· GenBank· DDBJ
Genomic DNA
JN833593
EMBL· GenBank· DDBJ
AET37164.1
EMBL· GenBank· DDBJ
Genomic DNA
JN833594
EMBL· GenBank· DDBJ
AET37165.1
EMBL· GenBank· DDBJ
Genomic DNA
JN833595
EMBL· GenBank· DDBJ
AET37166.1
EMBL· GenBank· DDBJ
Genomic DNA
JN833596
EMBL· GenBank· DDBJ
AET37167.1
EMBL· GenBank· DDBJ
Genomic DNA
JN833597
EMBL· GenBank· DDBJ
AET37168.1
EMBL· GenBank· DDBJ
Genomic DNA
JN860064
EMBL· GenBank· DDBJ
AET37243.1
EMBL· GenBank· DDBJ
Genomic DNA
JN860065
EMBL· GenBank· DDBJ
AET37244.1
EMBL· GenBank· DDBJ
Genomic DNA
KF698925
EMBL· GenBank· DDBJ
AHC30890.1
EMBL· GenBank· DDBJ
Genomic DNA
KF698926
EMBL· GenBank· DDBJ
AHC30891.1
EMBL· GenBank· DDBJ
Genomic DNA
KF698927
EMBL· GenBank· DDBJ
AHC30892.1
EMBL· GenBank· DDBJ
Genomic DNA
KF698928
EMBL· GenBank· DDBJ
AHC30893.1
EMBL· GenBank· DDBJ
Genomic DNA
KR045930
EMBL· GenBank· DDBJ
ALF07367.1
EMBL· GenBank· DDBJ
Genomic DNA
KR045932
EMBL· GenBank· DDBJ
ALF07369.1
EMBL· GenBank· DDBJ
Genomic DNA
KR045933
EMBL· GenBank· DDBJ
ALF07370.1
EMBL· GenBank· DDBJ
Genomic DNA
KR045934
EMBL· GenBank· DDBJ
ALF07371.1
EMBL· GenBank· DDBJ
Genomic DNA
KR046053
EMBL· GenBank· DDBJ
ALF07490.1
EMBL· GenBank· DDBJ
Genomic DNA
MF099661
EMBL· GenBank· DDBJ
ASO75192.1
EMBL· GenBank· DDBJ
Genomic DNA
MF099662
EMBL· GenBank· DDBJ
ASO75193.1
EMBL· GenBank· DDBJ
Genomic DNA
MF099663
EMBL· GenBank· DDBJ
ASO75194.1
EMBL· GenBank· DDBJ
Genomic DNA
MF099664
EMBL· GenBank· DDBJ
ASO75195.1
EMBL· GenBank· DDBJ
Genomic DNA
MF099665
EMBL· GenBank· DDBJ
ASO75196.1
EMBL· GenBank· DDBJ
Genomic DNA
MF099666
EMBL· GenBank· DDBJ
ASO75197.1
EMBL· GenBank· DDBJ
Genomic DNA
MG736833
EMBL· GenBank· DDBJ
AXN94107.1
EMBL· GenBank· DDBJ
Genomic DNA
MG736834
EMBL· GenBank· DDBJ
AXN94108.1
EMBL· GenBank· DDBJ
Genomic DNA
MG736835
EMBL· GenBank· DDBJ
AXN94109.1
EMBL· GenBank· DDBJ
Genomic DNA
MG736836
EMBL· GenBank· DDBJ
AXN94110.1
EMBL· GenBank· DDBJ
Genomic DNA
MG736837
EMBL· GenBank· DDBJ
AXN94111.1
EMBL· GenBank· DDBJ
Genomic DNA
MG736838
EMBL· GenBank· DDBJ
AXN94112.1
EMBL· GenBank· DDBJ
Genomic DNA
MG736839
EMBL· GenBank· DDBJ
AXN94113.1
EMBL· GenBank· DDBJ
Genomic DNA
MG736840
EMBL· GenBank· DDBJ
AXN94114.1
EMBL· GenBank· DDBJ
Genomic DNA
MG736841
EMBL· GenBank· DDBJ
AXN94115.1
EMBL· GenBank· DDBJ
Genomic DNA
MG736842
EMBL· GenBank· DDBJ
AXN94116.1
EMBL· GenBank· DDBJ
Genomic DNA
MG736843
EMBL· GenBank· DDBJ
AXN94117.1
EMBL· GenBank· DDBJ
Genomic DNA
MG736844
EMBL· GenBank· DDBJ
AXN94118.1
EMBL· GenBank· DDBJ
Genomic DNA
MG736845
EMBL· GenBank· DDBJ
AXN94119.1
EMBL· GenBank· DDBJ
Genomic DNA
MG736846
EMBL· GenBank· DDBJ
AXN94120.1
EMBL· GenBank· DDBJ
Genomic DNA
MG736847
EMBL· GenBank· DDBJ
AXN94121.1
EMBL· GenBank· DDBJ
Genomic DNA
MG736848
EMBL· GenBank· DDBJ
AXN94122.1
EMBL· GenBank· DDBJ
Genomic DNA
MG736849
EMBL· GenBank· DDBJ
AXN94123.1
EMBL· GenBank· DDBJ
Genomic DNA
MG736850
EMBL· GenBank· DDBJ
AXN94124.1
EMBL· GenBank· DDBJ
Genomic DNA
MG736851
EMBL· GenBank· DDBJ
AXN94125.1
EMBL· GenBank· DDBJ
Genomic DNA
MG736852
EMBL· GenBank· DDBJ
AXN94126.1
EMBL· GenBank· DDBJ
Genomic DNA
MG736853
EMBL· GenBank· DDBJ
AXN94127.1
EMBL· GenBank· DDBJ
Genomic DNA
MG736854
EMBL· GenBank· DDBJ
AXN94128.1
EMBL· GenBank· DDBJ
Genomic DNA
MG736855
EMBL· GenBank· DDBJ
AXN94129.1
EMBL· GenBank· DDBJ
Genomic DNA
MG736856
EMBL· GenBank· DDBJ
AXN94130.1
EMBL· GenBank· DDBJ
Genomic DNA
MG736857
EMBL· GenBank· DDBJ
AXN94131.1
EMBL· GenBank· DDBJ
Genomic DNA
MG736858
EMBL· GenBank· DDBJ
AXN94132.1
EMBL· GenBank· DDBJ
Genomic DNA
MG736859
EMBL· GenBank· DDBJ
AXN94133.1
EMBL· GenBank· DDBJ
Genomic DNA
MG736860
EMBL· GenBank· DDBJ
AXN94134.1
EMBL· GenBank· DDBJ
Genomic DNA
MG736861
EMBL· GenBank· DDBJ
AXN94135.1
EMBL· GenBank· DDBJ
Genomic DNA
MG736862
EMBL· GenBank· DDBJ
AXN94136.1
EMBL· GenBank· DDBJ
Genomic DNA
MG736863
EMBL· GenBank· DDBJ
AXN94137.1
EMBL· GenBank· DDBJ
Genomic DNA
MG736864
EMBL· GenBank· DDBJ
AXN94138.1
EMBL· GenBank· DDBJ
Genomic DNA
MG736865
EMBL· GenBank· DDBJ
AXN94139.1
EMBL· GenBank· DDBJ
Genomic DNA
MG736866
EMBL· GenBank· DDBJ
AXN94140.1
EMBL· GenBank· DDBJ
Genomic DNA
MG736867
EMBL· GenBank· DDBJ
AXN94141.1
EMBL· GenBank· DDBJ
Genomic DNA
MG736868
EMBL· GenBank· DDBJ
AXN94142.1
EMBL· GenBank· DDBJ
Genomic DNA
MG736869
EMBL· GenBank· DDBJ
AXN94143.1
EMBL· GenBank· DDBJ
Genomic DNA
MG736870
EMBL· GenBank· DDBJ
AXN94144.1
EMBL· GenBank· DDBJ
Genomic DNA
MG736871
EMBL· GenBank· DDBJ
AXN94145.1
EMBL· GenBank· DDBJ
Genomic DNA
MG736872
EMBL· GenBank· DDBJ
AXN94146.1
EMBL· GenBank· DDBJ
Genomic DNA
MG736873
EMBL· GenBank· DDBJ
AXN94147.1
EMBL· GenBank· DDBJ
Genomic DNA
MG736874
EMBL· GenBank· DDBJ
AXN94148.1
EMBL· GenBank· DDBJ
Genomic DNA
MG736875
EMBL· GenBank· DDBJ
AXN94149.1
EMBL· GenBank· DDBJ
Genomic DNA
MG736876
EMBL· GenBank· DDBJ
AXN94150.1
EMBL· GenBank· DDBJ
Genomic DNA
MG736877
EMBL· GenBank· DDBJ
AXN94151.1
EMBL· GenBank· DDBJ
Genomic DNA
MG736878
EMBL· GenBank· DDBJ
AXN94152.1
EMBL· GenBank· DDBJ
Genomic DNA
MG736879
EMBL· GenBank· DDBJ
AXN94153.1
EMBL· GenBank· DDBJ
Genomic DNA
MG736880
EMBL· GenBank· DDBJ
AXN94154.1
EMBL· GenBank· DDBJ
Genomic DNA
MG736881
EMBL· GenBank· DDBJ
AXN94155.1
EMBL· GenBank· DDBJ
Genomic DNA
MG736882
EMBL· GenBank· DDBJ
AXN94156.1
EMBL· GenBank· DDBJ
Genomic DNA
MG736883
EMBL· GenBank· DDBJ
AXN94157.1
EMBL· GenBank· DDBJ
Genomic DNA
MG736884
EMBL· GenBank· DDBJ
AXN94158.1
EMBL· GenBank· DDBJ
Genomic DNA
MG736885
EMBL· GenBank· DDBJ
AXN94159.1
EMBL· GenBank· DDBJ
Genomic DNA
MG736886
EMBL· GenBank· DDBJ
AXN94160.1
EMBL· GenBank· DDBJ
Genomic DNA
MG736887
EMBL· GenBank· DDBJ
AXN94161.1
EMBL· GenBank· DDBJ
Genomic DNA
MG736888
EMBL· GenBank· DDBJ
AXN94162.1
EMBL· GenBank· DDBJ
Genomic DNA
MG736889
EMBL· GenBank· DDBJ
AXN94163.1
EMBL· GenBank· DDBJ
Genomic DNA
MK064595
EMBL· GenBank· DDBJ
QCQ65691.1
EMBL· GenBank· DDBJ
Genomic DNA
MK064799
EMBL· GenBank· DDBJ
QCQ65895.1
EMBL· GenBank· DDBJ
Genomic DNA
MK064808
EMBL· GenBank· DDBJ
QCQ65904.1
EMBL· GenBank· DDBJ
Genomic DNA
MK064887
EMBL· GenBank· DDBJ
QCQ65983.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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