F8T3Z3 · F8T3Z3_GLOSP

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI
    • Synonyms
      COX1

Encoded on

  • Mitochondrion

Organism names

Accessions

  • Primary accession
    F8T3Z3

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane7-29Helical
Transmembrane49-75Helical
Transmembrane96-118Helical
Transmembrane138-163Helical
Transmembrane175-202Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-226Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    226
  • Mass (Da)
    24,492
  • Last updated
    2011-09-21 v1
  • Checksum
    851D48A8605E8D42
NHKDIGTLYLIFGAFSGVVGTTLSVLIRMELAQPGNQIFMGNHHLYNVVVTAHAFIMIFFMVMPVLIGGFGNWFVPLMIGAPDMAFPRMNNISFWLLPPSLLLLVSSAIVEAGAGTGWTVYPPLSSVQAHSGPSVDLAIFSLHLSGISSLLGAINFLSTIYNMRAPGLSFHRLPLFVWAIFITAFLLLLTLPVLAGAITMLLTDRNLNTSFYDPSGGGDPVLYQHL

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue226

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
HQ708836
EMBL· GenBank· DDBJ
ADW25184.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ708837
EMBL· GenBank· DDBJ
ADW25185.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ708838
EMBL· GenBank· DDBJ
ADW25186.1
EMBL· GenBank· DDBJ
Genomic DNA
LC273526
EMBL· GenBank· DDBJ
BAY00659.1
EMBL· GenBank· DDBJ
Genomic DNA
LC273527
EMBL· GenBank· DDBJ
BAY00660.1
EMBL· GenBank· DDBJ
Genomic DNA
LC273528
EMBL· GenBank· DDBJ
BAY00661.1
EMBL· GenBank· DDBJ
Genomic DNA
LC273529
EMBL· GenBank· DDBJ
BAY00662.1
EMBL· GenBank· DDBJ
Genomic DNA
LC273530
EMBL· GenBank· DDBJ
BAY00663.1
EMBL· GenBank· DDBJ
Genomic DNA
LC273531
EMBL· GenBank· DDBJ
BAY00664.1
EMBL· GenBank· DDBJ
Genomic DNA
LC273532
EMBL· GenBank· DDBJ
BAY00665.1
EMBL· GenBank· DDBJ
Genomic DNA
LC273533
EMBL· GenBank· DDBJ
BAY00666.1
EMBL· GenBank· DDBJ
Genomic DNA
LC273534
EMBL· GenBank· DDBJ
BAY00667.1
EMBL· GenBank· DDBJ
Genomic DNA
LC273535
EMBL· GenBank· DDBJ
BAY00668.1
EMBL· GenBank· DDBJ
Genomic DNA
LC273536
EMBL· GenBank· DDBJ
BAY00669.1
EMBL· GenBank· DDBJ
Genomic DNA
LC273539
EMBL· GenBank· DDBJ
BAY00672.1
EMBL· GenBank· DDBJ
Genomic DNA
LC273540
EMBL· GenBank· DDBJ
BAY00673.1
EMBL· GenBank· DDBJ
Genomic DNA
LC273541
EMBL· GenBank· DDBJ
BAY00674.1
EMBL· GenBank· DDBJ
Genomic DNA
LC273542
EMBL· GenBank· DDBJ
BAY00675.1
EMBL· GenBank· DDBJ
Genomic DNA
LC273543
EMBL· GenBank· DDBJ
BAY00676.1
EMBL· GenBank· DDBJ
Genomic DNA
LC273545
EMBL· GenBank· DDBJ
BAY00678.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp