F8RFM2 · F8RFM2_HHV1

Function

function

Envelope glycoprotein that binds to the potential host cell entry receptors TNFRSF14/HVEM, NECTIN1 and 3-O-sulfated heparan sulfate. May trigger fusion with host membrane, by recruiting the fusion machinery composed of gB and gH/gL.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthost cell Golgi apparatus
Cellular Componentmembrane
Cellular Componentviral envelope
Cellular Componentvirion membrane
Molecular Functionmetal ion binding
Biological Processentry receptor-mediated virion attachment to host cell
Biological Processsymbiont entry into host cell

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Envelope glycoprotein D

Gene names

    • Name
      US6
    • ORF names
      HHV1gp096
      , hmpv205_0067

Organism names

Accessions

  • Primary accession
    F8RFM2

Proteomes

Subcellular Location

Host Golgi apparatus
Virion membrane
; Single-pass type I membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane340-364Helical

Keywords

PTM/Processing

Keywords

Structure

3D structure databases

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain82-206Herpesvirus glycoprotein D/GG/GX
Region275-301Disordered

Sequence similarities

Belongs to the herpesviridae glycoprotein D family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    394
  • Mass (Da)
    43,317
  • Last updated
    2011-09-21 v1
  • Checksum
    905A0F0F1953CB7F
MGGAAARLGAVILFVVIVGLHGVRGKYALADASLKMADPNRFRGKDLPVLDQLTDPPGVRRVYHIQAGLPDPFQPPSLPITVYYAVLERACRSVLLNAPSEAPQIVRGASEDVRKQPYNLTIAWFRMGGNCAIPITVMEYTECSYNKSLGACPIRTQPRWNYYDSFSAVSEDNLGFLMHAPAFETAGTYLRLVKINDWTEITQFILEHRAKGSCKYALPLRIPPSACLSPQAYQQGVTVDSIGMLPRFIPENQRTVAVYSLKIAGWHGPKAPYTSTLLPPELSETPNATQPELAPEDPEDSALLEDPVGTVAPQIPPNWHIPSIQDAATPYHPPATPNNMGLIAGAVGGSLLAALVICGIVYWMHRRTRKAPKRIRLPHIREDDQPSSHQPLFY

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
HM585498
EMBL· GenBank· DDBJ
ADM22542.1
EMBL· GenBank· DDBJ
Genomic DNA
HM585511
EMBL· GenBank· DDBJ
ADM23531.1
EMBL· GenBank· DDBJ
Genomic DNA
JN420337
EMBL· GenBank· DDBJ
AER37715.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ673480
EMBL· GenBank· DDBJ
AFE62894.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ780693
EMBL· GenBank· DDBJ
AFI23657.1
EMBL· GenBank· DDBJ
Genomic DNA
KF498959
EMBL· GenBank· DDBJ
AGZ01928.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ847330
EMBL· GenBank· DDBJ
AKE48645.1
EMBL· GenBank· DDBJ
Genomic DNA
KR011279
EMBL· GenBank· DDBJ
AKG59609.1
EMBL· GenBank· DDBJ
Genomic DNA
KR052508
EMBL· GenBank· DDBJ
AKH80536.1
EMBL· GenBank· DDBJ
Genomic DNA
KT899744
EMBL· GenBank· DDBJ
ALO18662.1
EMBL· GenBank· DDBJ
Genomic DNA
KT887224
EMBL· GenBank· DDBJ
ALO18738.1
EMBL· GenBank· DDBJ
Genomic DNA
KX265023
EMBL· GenBank· DDBJ
ANN84041.1
EMBL· GenBank· DDBJ
Genomic DNA
KX791805
EMBL· GenBank· DDBJ
AOY34093.1
EMBL· GenBank· DDBJ
Genomic DNA
KY223525
EMBL· GenBank· DDBJ
ARO37963.1
EMBL· GenBank· DDBJ
Genomic DNA
MH160358
EMBL· GenBank· DDBJ
AWO69097.1
EMBL· GenBank· DDBJ
Genomic DNA
MG999838
EMBL· GenBank· DDBJ
AWW07837.1
EMBL· GenBank· DDBJ
Genomic DNA
MG708284
EMBL· GenBank· DDBJ
AWX34700.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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