F8RFM2 · F8RFM2_HHV1
- ProteinEnvelope glycoprotein D
- GeneUS6
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids394 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Envelope glycoprotein that binds to the potential host cell entry receptors TNFRSF14/HVEM, NECTIN1 and 3-O-sulfated heparan sulfate. May trigger fusion with host membrane, by recruiting the fusion machinery composed of gB and gH/gL.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | host cell Golgi apparatus | |
Cellular Component | membrane | |
Cellular Component | viral envelope | |
Cellular Component | virion membrane | |
Molecular Function | metal ion binding | |
Biological Process | entry receptor-mediated virion attachment to host cell | |
Biological Process | symbiont entry into host cell |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameEnvelope glycoprotein D
Gene names
Organism names
- Strains
- Taxonomic lineageViruses > Duplodnaviria > Heunggongvirae > Peploviricota > Herviviricetes > Herpesvirales > Orthoherpesviridae > Alphaherpesvirinae > Simplexvirus > Simplexvirus humanalpha1
- Virus hosts
Accessions
- Primary accessionF8RFM2
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Virion membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 340-364 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Family & Domains
Sequence
- Sequence statusComplete
- Length394
- Mass (Da)43,317
- Last updated2011-09-21 v1
- Checksum905A0F0F1953CB7F
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
HM585498 EMBL· GenBank· DDBJ | ADM22542.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM585511 EMBL· GenBank· DDBJ | ADM23531.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN420337 EMBL· GenBank· DDBJ | AER37715.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ673480 EMBL· GenBank· DDBJ | AFE62894.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ780693 EMBL· GenBank· DDBJ | AFI23657.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF498959 EMBL· GenBank· DDBJ | AGZ01928.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ847330 EMBL· GenBank· DDBJ | AKE48645.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR011279 EMBL· GenBank· DDBJ | AKG59609.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR052508 EMBL· GenBank· DDBJ | AKH80536.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT899744 EMBL· GenBank· DDBJ | ALO18662.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT887224 EMBL· GenBank· DDBJ | ALO18738.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX265023 EMBL· GenBank· DDBJ | ANN84041.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX791805 EMBL· GenBank· DDBJ | AOY34093.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY223525 EMBL· GenBank· DDBJ | ARO37963.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH160358 EMBL· GenBank· DDBJ | AWO69097.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG999838 EMBL· GenBank· DDBJ | AWW07837.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG708284 EMBL· GenBank· DDBJ | AWX34700.1 EMBL· GenBank· DDBJ | Genomic DNA |