F8IH90 · F8IH90_ALIAT

Function

function

Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per subunit.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.

Features

Showing features for binding site, active site.

143150100150200250300350400
TypeIDPosition(s)Description
Binding site62Zn2+ 1 (UniProtKB | ChEBI)
Binding site64Zn2+ 1 (UniProtKB | ChEBI)
Binding site64-66substrate
Binding site96substrate
Binding site154Zn2+ 1 (UniProtKB | ChEBI)
Binding site154Zn2+ 2 (UniProtKB | ChEBI)
Binding site181Zn2+ 2 (UniProtKB | ChEBI)
Binding site233Zn2+ 2 (UniProtKB | ChEBI)
Binding site279substrate
Active site306
Binding site306Zn2+ 1 (UniProtKB | ChEBI)
Binding site310substrate
Binding site324-325substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionallantoinase activity
Molecular Functiondihydroorotase activity
Molecular Functionzinc ion binding
Biological Process'de novo' UMP biosynthetic process
Biological Processpurine nucleobase catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Dihydroorotase
  • EC number
  • Short names
    DHOase

Gene names

    • Name
      pyrC
    • Ordered locus names
      TC41_1233

Organism names

Accessions

  • Primary accession
    F8IH90

Proteomes

Subcellular Location

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain54-421Amidohydrolase-related

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    431
  • Mass (Da)
    46,122
  • Last updated
    2011-09-21 v1
  • Checksum
    9ECF6201CF052152
MRIRWDGGRVWDSGLGDFMEASVAFDTETGEIVAVGHPSAIRADEVRSIRGLCVLPGFVDVHVHLRDPGLTHKETLASGLQAAAAGGFTQVACMPNTKPPIARAEIVEDIIRRGEAIGKAEVHPIACLTLDQEGEALADYEALAEAGAMGFSDDGRGVQDGGLMREALAKLAALGKPAMIHAEDESISRGGALHERAAARLGTTAQPGSAEAAMIARDILLAEETGAHLHVCHVSREASAALVQFGKRRGIRVTAEVTPHHLLLSERDIQSADANWKVNPPLASEEDRRACLVAFADGTLDIIATDHAPHHPDEKAKGMDEAPFGMVGLEMAFALLYTGLVCEGLVPMRRLVEAMSERPCRLFGLEGGQIRPGARADLVLVDLGRRWTIDPSTLYTKGRNTPFAGQSVVGKVIETIRAGRVIFREGEERLS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP002902
EMBL· GenBank· DDBJ
AEJ43175.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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