F7ZBA2 · F7ZBA2_ROSLO
- Protein3-dehydroquinate synthase
- GenearoB
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids370 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
Catalytic activity
- 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate
Cofactor
Protein has several cofactor binding sites:
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )
Note: Binds 1 divalent metal cation per subunit. Can use either Co2+ or Zn2+.
Pathway
Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 107-111 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: GVIGD | ||||||
Binding site | 131-132 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: TS | ||||||
Binding site | 144 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 153 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 186 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 249 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 267 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | 3-dehydroquinate synthase activity | |
Molecular Function | metal ion binding | |
Molecular Function | nucleotide binding | |
Biological Process | amino acid biosynthetic process | |
Biological Process | aromatic amino acid family biosynthetic process | |
Biological Process | chorismate biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name3-dehydroquinate synthase
- EC number
- Short namesDHQS
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Rhodobacterales > Roseobacteraceae > Roseobacter
Accessions
- Primary accessionF7ZBA2
Proteomes
Subcellular Location
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 69-332 | 3-dehydroquinate synthase | ||||
Sequence: LALPAGEATKSWEPLERTVGWLLDQKVERGDVVVAFGGGVIGDLAGFAAAILRRGVRFVQIPTSLLAQVDSSVGGKTGINAAQGKNLIGAFHQPSLVLADIDVLGSLTARDFLAGYGEVVKYGLLGDLAFFEWLEENGPTLAVGNQQARCEAVRRSVQMKADIVIRDETEQGDRALLNLGHTFGHALEAATGYSDRLLHGEGVAIGCAMAFELSSRMGLCSQESPSRVRAHLKAMGMKTDLRDIPGELPDAAGLLDLMGQDKKV |
Sequence similarities
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length370
- Mass (Da)39,169
- Last updated2011-09-21 v1
- Checksum9FADCDA5E3A34FFF
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP002623 EMBL· GenBank· DDBJ | AEI94288.1 EMBL· GenBank· DDBJ | Genomic DNA |