F7W4N9 · F7W4N9_SORMK

Function

function

Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

GO annotations

AspectTerm
Cellular Componentmitochondrion
Cellular Componentnucleus
Molecular Functionclass I DNA-(apurinic or apyrimidinic site) endonuclease activity
Molecular FunctionDNA binding
Molecular Functionoxidized pyrimidine nucleobase lesion DNA N-glycosylase activity
Biological Processbase-excision repair, AP site formation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Endonuclease III homolog
  • EC number
  • Alternative names
    • Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase
      (DNA glycosylase/AP lyase
      )

Gene names

    • Name
      NTH1
    • ORF names
      SMAC_06555

Organism names

Accessions

  • Primary accession
    F7W4N9

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, domain, compositional bias.

TypeIDPosition(s)Description
Region25-55Disordered
Region132-156Disordered
Domain219-381HhH-GPD
Region489-792Disordered
Compositional bias528-667Basic and acidic residues
Compositional bias679-738Basic and acidic residues
Compositional bias748-792Basic and acidic residues

Sequence similarities

Belongs to the Nth/MutY family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    805
  • Mass (Da)
    90,705
  • Last updated
    2011-09-21 v1
  • Checksum
    3E411018B2D4BB24
MVTPATPRRSTRLSTLARFAYEANNANASSSSAPADLRSSPVRVDEEHAEDEDGITFGSDIEDAVKSNGSPAVKVKRRNPIGTRKRKATVLKNEEPLPAPTRIKTERKSTRIITQTAEAEVKSDSEIDMNDIPAVGTSATSSKKRTARKPARKTTDALTGEVKVEPPSDWEEVYRLVKEMRISGPAANAAVDTMGCERLASNNASARDRRFHTLVALMLSSQTKDTVNAEAMLRLKKELPPHTEGAEPGLNLENMLAVEPTLLNELIGKVGFHNNKTKYLKQAAEILRDRYNSDIPDTIEGLMSLPGVGPKMAHLCMSAENGWNRVEGIGVDVHVHRITNLWGWQNPPTKTPEETRLALQSWLPRDKWKEINWLLVGFGQSVCLPVGRKCGDCELGLRGLCKSAERKKVIEGRKRREVVKEEKVEVEIEEDRRGMVIKREKRERKVKVKEEQETRARDVVNEPVPPAVREAAADEDVKMESTEDVEMEDADEAQSGIGNNGPAIVKHEGDTDIKPTTEHSPPMIIKQEGMRVKRERLANEKEDNEEADRQPVVKEEVPRVKEEQRVHEVAAEEEENQLPNVIKRETGRVKQEPNTHDEEGESARRRRVVKRESQRDLSTVKQELGNDEQEDDLQPQSVKPEHPRVKREFYGQGQGEEENHRPRTVKRESLNGATIVKREPNLDNDDAEDRQARSVKREPLLERVSVKQEPNIADGEEQEGHHGPAIVKREAGQVKQEAEEDKEDEEQLDEPVVKSESVKREQDPVRVKREAVDEGGEEEEEGLHVKTEHGRVKVEDGMARIKLER

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias528-667Basic and acidic residues
Compositional bias679-738Basic and acidic residues
Compositional bias748-792Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CABT02000028
EMBL· GenBank· DDBJ
CCC12476.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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