F7W4N9 · F7W4N9_SORMK
- ProteinEndonuclease III homolog
- GeneNTH1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids805 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.
Catalytic activity
- 2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H+
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrion | |
Cellular Component | nucleus | |
Molecular Function | class I DNA-(apurinic or apyrimidinic site) endonuclease activity | |
Molecular Function | DNA binding | |
Molecular Function | oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity | |
Biological Process | base-excision repair, AP site formation |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameEndonuclease III homolog
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Sordariomycetidae > Sordariales > Sordariaceae > Sordaria
Accessions
- Primary accessionF7W4N9
Proteomes
Organism-specific databases
Subcellular Location
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, domain, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 25-55 | Disordered | ||||
Sequence: NANASSSSAPADLRSSPVRVDEEHAEDEDGI | ||||||
Region | 132-156 | Disordered | ||||
Sequence: IPAVGTSATSSKKRTARKPARKTTD | ||||||
Domain | 219-381 | HhH-GPD | ||||
Sequence: LSSQTKDTVNAEAMLRLKKELPPHTEGAEPGLNLENMLAVEPTLLNELIGKVGFHNNKTKYLKQAAEILRDRYNSDIPDTIEGLMSLPGVGPKMAHLCMSAENGWNRVEGIGVDVHVHRITNLWGWQNPPTKTPEETRLALQSWLPRDKWKEINWLLVGFGQS | ||||||
Region | 489-792 | Disordered | ||||
Sequence: DADEAQSGIGNNGPAIVKHEGDTDIKPTTEHSPPMIIKQEGMRVKRERLANEKEDNEEADRQPVVKEEVPRVKEEQRVHEVAAEEEENQLPNVIKRETGRVKQEPNTHDEEGESARRRRVVKRESQRDLSTVKQELGNDEQEDDLQPQSVKPEHPRVKREFYGQGQGEEENHRPRTVKRESLNGATIVKREPNLDNDDAEDRQARSVKREPLLERVSVKQEPNIADGEEQEGHHGPAIVKREAGQVKQEAEEDKEDEEQLDEPVVKSESVKREQDPVRVKREAVDEGGEEEEEGLHVKTEHGRV | ||||||
Compositional bias | 528-667 | Basic and acidic residues | ||||
Sequence: EGMRVKRERLANEKEDNEEADRQPVVKEEVPRVKEEQRVHEVAAEEEENQLPNVIKRETGRVKQEPNTHDEEGESARRRRVVKRESQRDLSTVKQELGNDEQEDDLQPQSVKPEHPRVKREFYGQGQGEEENHRPRTVKR | ||||||
Compositional bias | 679-738 | Basic and acidic residues | ||||
Sequence: EPNLDNDDAEDRQARSVKREPLLERVSVKQEPNIADGEEQEGHHGPAIVKREAGQVKQEA | ||||||
Compositional bias | 748-792 | Basic and acidic residues | ||||
Sequence: LDEPVVKSESVKREQDPVRVKREAVDEGGEEEEEGLHVKTEHGRV |
Sequence similarities
Belongs to the Nth/MutY family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length805
- Mass (Da)90,705
- Last updated2011-09-21 v1
- Checksum3E411018B2D4BB24
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 528-667 | Basic and acidic residues | ||||
Sequence: EGMRVKRERLANEKEDNEEADRQPVVKEEVPRVKEEQRVHEVAAEEEENQLPNVIKRETGRVKQEPNTHDEEGESARRRRVVKRESQRDLSTVKQELGNDEQEDDLQPQSVKPEHPRVKREFYGQGQGEEENHRPRTVKR | ||||||
Compositional bias | 679-738 | Basic and acidic residues | ||||
Sequence: EPNLDNDDAEDRQARSVKREPLLERVSVKQEPNIADGEEQEGHHGPAIVKREAGQVKQEA | ||||||
Compositional bias | 748-792 | Basic and acidic residues | ||||
Sequence: LDEPVVKSESVKREQDPVRVKREAVDEGGEEEEEGLHVKTEHGRV |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CABT02000028 EMBL· GenBank· DDBJ | CCC12476.1 EMBL· GenBank· DDBJ | Genomic DNA |