F7W079 · F7W079_SORMK
- Proteinalpha-1,2-Mannosidase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids638 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- 3 H2O + N4-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) = 3 beta-D-mannose + N4-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)
- 4 H2O + N4-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) = 4 beta-D-mannose + N4-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)
Cofactor
Pathway
Protein modification; protein glycosylation.
Features
Showing features for active site, binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Molecular Function | calcium ion binding | |
Molecular Function | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity | |
Biological Process | carbohydrate metabolic process | |
Biological Process | ERAD pathway | |
Biological Process | protein glycosylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namealpha-1,2-Mannosidase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Sordariomycetidae > Sordariales > Sordariaceae > Sordaria
Accessions
- Primary accessionF7W079
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Disulfide bond | 372↔401 | |||||
Sequence: CFDGGNFILGGLTLSSSKYLEFGLELVKSC |
Keywords
- PTM
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 36-72 | Disordered | ||||
Sequence: TPFPQPQPQPQQKHIGTVDSSSAAASSQAESVSNQGR | ||||||
Compositional bias | 45-72 | Polar residues | ||||
Sequence: PQQKHIGTVDSSSAAASSQAESVSNQGR | ||||||
Region | 561-638 | Disordered | ||||
Sequence: LAKGRETQPSSSSSGSGSSSGSGSGYGSGGDRGGKNNGHGHHQGGHQEGQGVWRYGDDDGYGNGKGREKKRFSGPRHA | ||||||
Compositional bias | 565-586 | Polar residues | ||||
Sequence: RETQPSSSSSGSGSSSGSGSGY |
Sequence similarities
Belongs to the glycosyl hydrolase 47 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length638
- Mass (Da)70,098
- Last updated2011-09-21 v1
- ChecksumD0A8591D98F23E60
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 45-72 | Polar residues | ||||
Sequence: PQQKHIGTVDSSSAAASSQAESVSNQGR | ||||||
Compositional bias | 565-586 | Polar residues | ||||
Sequence: RETQPSSSSSGSGSSSGSGSGY |
Keywords
- Technical term