F7RQE3 · F7RQE3_9GAMM
- ProteinFatty acid oxidation complex subunit alpha
- GenefadJ
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids708 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities.
Catalytic activity
- (3S)-3-hydroxybutanoyl-CoA = (3R)-3-hydroxybutanoyl-CoA
Pathway
Lipid metabolism; fatty acid beta-oxidation.
Features
Showing features for site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 116 | Important for catalytic activity | ||||
Sequence: E | ||||||
Site | 138 | Important for catalytic activity | ||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | 3-hydroxyacyl-CoA dehydrogenase activity | |
Molecular Function | 3-hydroxybutyryl-CoA epimerase activity | |
Molecular Function | enoyl-CoA hydratase activity | |
Molecular Function | NAD+ binding | |
Biological Process | fatty acid beta-oxidation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameFatty acid oxidation complex subunit alpha
Including 2 domains:
- Recommended nameEnoyl-CoA hydratase/3-hydroxybutyryl-CoA epimerase
- EC number
- Recommended name3-hydroxyacyl-CoA dehydrogenase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Alteromonadales > Shewanellaceae > Shewanella
Accessions
- Primary accessionF7RQE3
Proteomes
Subcellular Location
Interaction
Subunit
Heterotetramer of two alpha chains (FadJ) and two beta chains (FadI).
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-188 | Enoyl-CoA hydratase | ||||
Sequence: MEKTFNLTRRDDGIAILTMDVPGETMNTLKAQFGPEISEILAEIKRDSSIRGLVLISGKKDSFVAGADISMLDACKTASDAKALSQQGHVVFNELEALTIPVVAAIHGACLGGGLELALACHQRVCSDDGKTMLGVPEVQLGLLPGGGGTQRLPRLVGITTALDMMLTGKQIRPKQALKMGLVNDVVP | ||||||
Region | 308-708 | 3-hydroxyacyl-CoA dehydrogenase | ||||
Sequence: RKVKKAVILGGGLMGGGIASVTTTKAKIPARVKDINEKGLSNALAYAYKLLDKGVKRRHMTPAARDNLMALMTTTTEYKGVKDADIVVEAVFEDLALKHQMVKDIERECGEHTIFASNTSSLPISQIAEAATRPENVIGLHYFSPVEKMPLVEVIAHAKTSPETIATTVAFARKQGKTPIVVQDGAGFYVNRILALYMNEAAQLLLEGQSVEHLDKALVKFGFPVGPITLLDEVGIDVGAKISPILEKELGERFKAPAAFDKLLGDDRKGRKNGKGFYQYGQKDSSKKAKVVDESVYGVLGIKPGTNKDAKAVAERCVVQMLNEAVRCLDEGIIASPRDGDIGAIFGIGFPPFLGGPFHYIDTLGAANLVRILEGYQSQLGDRFEPCERLKAMAQENRRFF | ||||||
Domain | 313-491 | 3-hydroxyacyl-CoA dehydrogenase NAD binding | ||||
Sequence: AVILGGGLMGGGIASVTTTKAKIPARVKDINEKGLSNALAYAYKLLDKGVKRRHMTPAARDNLMALMTTTTEYKGVKDADIVVEAVFEDLALKHQMVKDIERECGEHTIFASNTSSLPISQIAEAATRPENVIGLHYFSPVEKMPLVEVIAHAKTSPETIATTVAFARKQGKTPIVVQD | ||||||
Domain | 494-587 | 3-hydroxyacyl-CoA dehydrogenase C-terminal | ||||
Sequence: GFYVNRILALYMNEAAQLLLEGQSVEHLDKALVKFGFPVGPITLLDEVGIDVGAKISPILEKELGERFKAPAAFDKLLGDDRKGRKNGKGFYQY | ||||||
Domain | 620-705 | 3-hydroxyacyl-CoA dehydrogenase C-terminal | ||||
Sequence: VAERCVVQMLNEAVRCLDEGIIASPRDGDIGAIFGIGFPPFLGGPFHYIDTLGAANLVRILEGYQSQLGDRFEPCERLKAMAQENR |
Sequence similarities
In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.
In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length708
- Mass (Da)76,271
- Last updated2011-09-21 v1
- Checksum2E5A2019A2EADCE2