F7Q8E1 · F7Q8E1_9GAMM

Function

function

Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 2 magnesium ions per subunit.

Features

Showing features for binding site, site, active site.

Type
IDPosition(s)Description
Binding site20Mg2+ (UniProtKB | ChEBI)
Site25Substrate discrimination
Binding site114Mg2+ (UniProtKB | ChEBI)
Active site115

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functiondamaged DNA binding
Molecular FunctionDNA-directed DNA polymerase activity
Molecular Functionmagnesium ion binding
Biological ProcessDNA-templated DNA replication
Biological Processerror-prone translesion synthesis
Biological ProcessSOS response

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA polymerase IV
  • EC number
  • Short names
    Pol IV

Gene names

    • Name
      dinB
    • ORF names
      SSPSH_002678

Organism names

  • Taxonomic identifier
  • Strain
    • E1L3A
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Salinisphaerales > Salinisphaeraceae > Salinisphaera

Accessions

  • Primary accession
    F7Q8E1

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain16-196UmuC

Sequence similarities

Belongs to the DNA polymerase type-Y family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    365
  • Mass (Da)
    40,762
  • Last updated
    2011-09-21 v1
  • MD5 Checksum
    011B06A0F106C13DCEDCE974544DD05A
MNAQTETSASAPLRKIVHVDMDAFYASVEQRDDPSLQGKPVVVAKRGLRSVVTAASYEARVFGVRSAMPAMRAERLCPQAIFVDPHFDRYRAISRQIREIFLRHTDLVEPLSLDEAYLDVTVTHTNMPSATEAARVIRAEILEVTGLTASAGIAPNKFLAKIASDWRKPNGQFVVTPKRVDAFLLPLPIGKVPGVGPKMKEKLAALDVHTVGDLRAFEQAELVKRYGRWGRRLYELARGIDERPVQPKRDAAQVSSEDTLREDLRLDELAEHIQRLAEKTWANHERKLPRVARTVVLKLKTTDFQILTRSFTPPSRPTSATELADIACALRDRVDADPNTRYRLVGVGLSGFVDSREEAVQPSLL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AFNV02000019
EMBL· GenBank· DDBJ
ERJ18397.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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