F7J186 · NVD1_CIOIN

Function

function

Catalyzes the production of 7-dehydrocholesterol (7-DHC or cholesta-5,7-dien-3beta-ol) by inserting a double bond (desaturating) at the C7-C8 single bond of cholesterol. Essential regulator of steroid biosynthesis as this reaction is the first step in the synthesis of the steroid hormone Delta7-dafachronic acid.

Catalytic activity

Cofactor

[2Fe-2S] cluster (UniProtKB | Rhea| CHEBI:190135 )

Note: Binds 1 [2Fe-2S] cluster per subunit.

Pathway

Steroid hormone biosynthesis; dafachronic acid biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site176[2Fe-2S] cluster (UniProtKB | ChEBI)
Binding site178[2Fe-2S] cluster (UniProtKB | ChEBI)
Binding site196[2Fe-2S] cluster (UniProtKB | ChEBI)
Binding site199[2Fe-2S] cluster (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentmembrane
Molecular Function2 iron, 2 sulfur cluster binding
Molecular Functioncholesterol 7-desaturase (NAD(P)H) activity
Molecular Functionmetal ion binding
Molecular Functionoxidoreductase activity
Biological Processcholesterol metabolic process

Keywords

Enzyme and pathway databases

Chemistry

Names & Taxonomy

Protein names

  • Recommended name
    Cholesterol 7-desaturase nvd 1
  • EC number
  • Alternative names
    • Neverland 1
      (Nvd-Ci-1
      )

Gene names

    • Name
      nvd-Ci-1

Organism names

Accessions

  • Primary accession
    F7J186
  • Secondary accessions
    • A0A1W2W1E1
    • F6WF51

Proteomes

Subcellular Location

Membrane
; Single-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane67-87Helical

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004526071-470Cholesterol 7-desaturase nvd 1

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain136-238Rieske

Sequence similarities

Belongs to the cholesterol 7-desaturase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    470
  • Mass (Da)
    53,548
  • Last updated
    2021-06-02 v2
  • Checksum
    83D5152CFD14105C
MISRIPRLLFENILVPVADVLTKSVSNFAGHKSDQSYNSNATRVSTISDEEIEFYLNLKSAVLLLCLALCIAGFSVLMYFLYVLVFVPYNRVKRLGSIGYQNHEEGHLSKKDIANLVRRRRKVGDDLPPVFPNGWFRLVDSQQLEPGQVKQVTALGEHFAVFRSKSGKASILDAYCPHMGGNLAVGGIVKNDCLECPFHGWRFDGDGKCVAIPYSEKIPTFAKTKSWPCREVNKAIFVWFHCDGKEPEWEIPDISEISTGKFTYKGRVEHHANTHIQDVPENGSDLAHLSHLHVPHAMSGANLSTQYSSWWNFAEHIFKAQCIGPADGEPHISLFYLTHYLHVFKRFKLLSLNLNVYQIGPGIVHLHFDSPFGKGVFVQTLTPVEPLHLVLTHNLHASWSIPVWLGRIFLYLEAIQVDRDVMIWNNKTFEPRPKLLKEDSLIAKYRRWYSQFYTENSPRLTLKSEDGNGW

Sequence caution

The sequence EAAA01002278 differs from that shown. Reason: Erroneous gene model prediction

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict296in Ref. 1; BAK39961

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB607952
EMBL· GenBank· DDBJ
BAK39961.1
EMBL· GenBank· DDBJ
mRNA
EAAA01002278
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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