F7IDL6 · F7IDL6_CALJA
- ProteinEpoxide hydrolase
- GeneEPHX1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids455 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water.
Catalytic activity
- 1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine + H2O = 2-{[(4-methoxybenzyl)(methyl)amino]methyl}-2-methylpropane-1,3-diol
- 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O = 11,12-dihydroxy-(5Z,8Z,14Z)-eicosatrienoateThis reaction proceeds in the forward direction.
- 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H+This reaction proceeds in the forward direction.
- 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O = 8,9-dihydroxy-(5Z,11Z,14Z)-eicosatrienoateThis reaction proceeds in the forward direction.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 226 | Nucleophile | ||||
Sequence: D | ||||||
Active site | 374 | Proton donor | ||||
Sequence: Y | ||||||
Active site | 431 | Proton acceptor | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | cis-stilbene-oxide hydrolase activity | |
Biological Process | arachidonic acid metabolic process | |
Biological Process | catabolic process | |
Biological Process | epoxide metabolic process | |
Biological Process | response to toxic substance |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameEpoxide hydrolase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Platyrrhini > Cebidae > Callitrichinae > Callithrix > Callithrix
Accessions
- Primary accessionF7IDL6
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Single-pass type III membrane protein
Membrane ; Single-pass type III membrane protein
Microsome membrane ; Single-pass type III membrane protein
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 48-157 | Epoxide hydrolase N-terminal | ||||
Sequence: IRPFKVETSDEEIHDLHQRIDKFRFTPPLEDSCFHYGFNSNYLKKVISYWRNEFDWKKQVEILNRYPHFKTKIEGLDIHFIHVKPPQLPAGRTPKPLLMVHGWPGSFYEF |
Sequence similarities
Belongs to the peptidase S33 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length455
- Mass (Da)53,026
- Last updated2011-07-27 v1
- Checksum797BDCF5E206E2F7
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
F7BK21 | F7BK21_CALJA | EPHX1 | 431 | ||
A0A8I4A0U4 | A0A8I4A0U4_CALJA | EPHX1 | 417 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
GAMT01000007 EMBL· GenBank· DDBJ | JAB11854.1 EMBL· GenBank· DDBJ | mRNA | ||
GAMS01006030 EMBL· GenBank· DDBJ | JAB17106.1 EMBL· GenBank· DDBJ | mRNA | ||
GAMR01009568 EMBL· GenBank· DDBJ | JAB24364.1 EMBL· GenBank· DDBJ | mRNA | ||
GAMQ01007889 EMBL· GenBank· DDBJ | JAB33962.1 EMBL· GenBank· DDBJ | mRNA | ||
GAMP01008305 EMBL· GenBank· DDBJ | JAB44450.1 EMBL· GenBank· DDBJ | mRNA |