F7HNX8 · F7HNX8_CALJA
- Protein[histone H3]-trimethyl-L-lysine(4) demethylase
- GeneKDM5B
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1544 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
Catalytic activity
- N6,N6,N6-trimethyl-L-lysyl4-[histone H3] + 3 2-oxoglutarate + 3 O2 = L-lysyl4-[histone H3] + 3 formaldehyde + 3 succinate + 3 CO2
RHEA-COMP:15537 CHEBI:61961 Position: 4+ 3 CHEBI:16810 + 3 CHEBI:15379 = RHEA-COMP:15547 + 3 CHEBI:16842 + 3 CHEBI:30031 + 3 CHEBI:16526
Cofactor
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | chromatin | |
Cellular Component | cytosol | |
Cellular Component | nucleoplasm | |
Molecular Function | histone binding | |
Molecular Function | histone H3K4me/H3K4me2/H3K4me3 demethylase activity | |
Molecular Function | methyltransferase activity | |
Molecular Function | sequence-specific double-stranded DNA binding | |
Molecular Function | transcription corepressor activity | |
Molecular Function | zinc ion binding | |
Biological Process | branching involved in mammary gland duct morphogenesis | |
Biological Process | cellular response to leukemia inhibitory factor | |
Biological Process | mammary duct terminal end bud growth | |
Biological Process | methylation | |
Biological Process | positive regulation of gene expression | |
Biological Process | positive regulation of mammary gland epithelial cell proliferation | |
Biological Process | post-embryonic development | |
Biological Process | regulation of estradiol secretion | |
Biological Process | single fertilization | |
Biological Process | uterus morphogenesis |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name[histone H3]-trimethyl-L-lysine(4) demethylase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Platyrrhini > Cebidae > Callitrichinae > Callithrix > Callithrix
Accessions
- Primary accessionF7HNX8
- Secondary accessions
Proteomes
Subcellular Location
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, domain, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-22 | Disordered | |||
Domain | 32-73 | JmjN | |||
Domain | 97-187 | ARID | |||
Region | 201-231 | Disordered | |||
Domain | 309-359 | PHD-type | |||
Domain | 453-619 | JmjC | |||
Domain | 1176-1224 | PHD-type | |||
Compositional bias | 1374-1390 | Polar residues | |||
Region | 1374-1401 | Disordered | |||
Domain | 1484-1538 | PHD-type | |||
Sequence similarities
Belongs to the JARID1 histone demethylase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,544
- Mass (Da)175,719
- Last updated2022-05-25 v3
- Checksum29A99484ECA33F89
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A5F4W9R6 | A0A5F4W9R6_CALJA | KDM5B | 1499 | ||
A0A5F4VVW4 | A0A5F4VVW4_CALJA | KDM5B | 211 | ||
A0A5F4VW03 | A0A5F4VW03_CALJA | KDM5B | 1505 | ||
A0A8I3WVE6 | A0A8I3WVE6_CALJA | KDM5B | 1493 | ||
A0A5F4WE98 | A0A5F4WE98_CALJA | KDM5B | 1503 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 1374-1390 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
GAMP01007858 EMBL· GenBank· DDBJ | JAB44897.1 EMBL· GenBank· DDBJ | mRNA |