F7H8D5 · F7H8D5_MACMU
- ProteinPhosphodiesterase
- GenePDE1B
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids536 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate.
Catalytic activity
- 3',5'-cyclic AMP + H2O = AMP + H+This reaction proceeds in the forward direction.
- 3',5'-cyclic GMP + H2O = GMP + H+This reaction proceeds in the forward direction.
Cofactor
Protein has several cofactor binding sites:
Note: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 223 | Proton donor | |||
Binding site | 223-227 | AMP (UniProtKB | ChEBI) | |||
Binding site | 227 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 263 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 264 | AMP (UniProtKB | ChEBI) | |||
Binding site | 264 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 264 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 370 | AMP (UniProtKB | ChEBI) | |||
Binding site | 370 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 421 | AMP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | 3',5'-cyclic-nucleotide phosphodiesterase activity | |
Molecular Function | metal ion binding | |
Biological Process | signal transduction |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphodiesterase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Cercopithecinae > Macaca
Accessions
- Primary accessionF7H8D5
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Expression
Gene expression databases
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for region, coiled coil, domain, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-20 | Disordered | |||
Coiled coil | 39-91 | ||||
Domain | 146-503 | PDEase | |||
Region | 447-473 | Disordered | |||
Compositional bias | 450-464 | Polar residues | |||
Region | 494-536 | Disordered | |||
Sequence similarities
Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length536
- Mass (Da)61,351
- Last updated2011-07-27 v1
- MD5 Checksum83C06944C67E2DAAF7AA77D323249DBB
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A1D5Q8U6 | A0A1D5Q8U6_MACMU | PDE1B | 538 | ||
A0A5F7ZUQ0 | A0A5F7ZUQ0_MACMU | PDE1B | 198 | ||
A0A5F8A5S6 | A0A5F8A5S6_MACMU | PDE1B | 494 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 450-464 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JU322545 EMBL· GenBank· DDBJ | AFE66301.1 EMBL· GenBank· DDBJ | mRNA |