F7H8D5 · F7H8D5_MACMU

Function

function

Cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Note: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

Features

Showing features for active site, binding site.

Type
IDPosition(s)Description
Active site223Proton donor
Binding site223-227AMP (UniProtKB | ChEBI)
Binding site227Zn2+ 1 (UniProtKB | ChEBI)
Binding site263Zn2+ 1 (UniProtKB | ChEBI)
Binding site264AMP (UniProtKB | ChEBI)
Binding site264Zn2+ 2 (UniProtKB | ChEBI)
Binding site264Zn2+ 1 (UniProtKB | ChEBI)
Binding site370AMP (UniProtKB | ChEBI)
Binding site370Zn2+ 1 (UniProtKB | ChEBI)
Binding site421AMP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Function3',5'-cyclic-nucleotide phosphodiesterase activity
Molecular Functionmetal ion binding
Biological Processsignal transduction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphodiesterase
  • EC number

Gene names

    • Name
      PDE1B

Organism names

  • Taxonomic identifier
  • Strain
    • 17573
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Cercopithecinae > Macaca

Accessions

  • Primary accession
    F7H8D5
  • Secondary accessions
    • G7N774

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Keywords

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for region, coiled coil, domain, compositional bias.

Type
IDPosition(s)Description
Region1-20Disordered
Coiled coil39-91
Domain146-503PDEase
Region447-473Disordered
Compositional bias450-464Polar residues
Region494-536Disordered

Sequence similarities

Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    536
  • Mass (Da)
    61,351
  • Last updated
    2011-07-27 v1
  • MD5 Checksum
    83C06944C67E2DAAF7AA77D323249DBB
MELSPRSPPEMLEESDCPSPLELKSAPSKKMWIKLRSLLRYMVKQLENGEVNIEELKKNLEYTASLLEAVYIDETRQILDTEDELQELRSDAVPSEVRDWLASTFTQQARAKGRRAEEKPKFRSIVHAVQAGIFVERMFRRTYTSVGPTYSTAVLNCFKNLDLWCFDVFSLNRAADDHALRTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGKYKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIEVLAIVFAAAIHDYEHTGTTNSFHIQTKSECAILYNDRSVLENHHISSVFRLMQDDELNIFINLTKDEFVELRALVIEMVLATDMSCHFQQVKTMKTALQQLERIDKPKALSLLLHAADISHPTKQWSVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQPLADEDSKSKNQPSFQWRQPSLDVEVGDPNPDVVSFRSTWIKHIQENKQKWKERAASGITNQMSIDELSPCDEEAPPSPAEDEHNQNGNLD

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A1D5Q8U6A0A1D5Q8U6_MACMUPDE1B538
A0A5F7ZUQ0A0A5F7ZUQ0_MACMUPDE1B198
A0A5F8A5S6A0A5F8A5S6_MACMUPDE1B494

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias450-464Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JU322545
EMBL· GenBank· DDBJ
AFE66301.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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