F7GSQ4 · TRM5_MACMU
- ProteintRNA (guanine(37)-N(1))-methyltransferase
- GeneTRMT5
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids509 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Involved in mitochondrial tRNA methylation (By similarity).
Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding
Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding
Catalytic activity
- guanosine37 in tRNA + S-adenosyl-L-methionine = N1-methylguanosine37 in tRNA + S-adenosyl-L-homocysteine + H+
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 289 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Binding site | 327-328 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Binding site | 355-356 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Binding site | 387 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | mitochondrial matrix | |
Cellular Component | nucleus | |
Molecular Function | tRNA (guanine(37)-N1)-methyltransferase activity | |
Molecular Function | tRNA methyltransferase activity | |
Biological Process | mitochondrial tRNA methylation | |
Biological Process | tRNA N1-guanine methylation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nametRNA (guanine(37)-N(1))-methyltransferase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Cercopithecinae > Macaca
Accessions
- Primary accessionF7GSQ4
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Predominantly in the mitochondria and in the nucleus.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for transit peptide, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transit peptide | 1-57 | Mitochondrion | |||
Chain | PRO_0000414122 | 58-509 | tRNA (guanine37-N1)-methyltransferase | ||
Proteomic databases
Expression
Gene expression databases
Interaction
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 478-509 | Disordered | |||
Compositional bias | 479-498 | Basic and acidic residues | |||
Sequence similarities
Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length509
- Mass (Da)58,277
- Last updated2011-07-27 v1
- ChecksumBD4B4B2B2FB1BF06
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A1I7Q472 | A0A1I7Q472_MACMU | TRMT5 | 488 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 479-498 | Basic and acidic residues | |||
Keywords
- Technical term