F7F5D8 · F7F5D8_MACMU

Function

function

Soluble form that is released in blood plasma and other body fluids following proteolytic cleavage in the juxtamembrane stalk region.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

  • Leu-enkephalin + H2O = L-tyrosylglycylglycine + L-phenylalanyl-L-leucine
    This reaction proceeds in the forward direction.
  • Met-enkephalin + H2O = L-phenylalanyl-L-methionine + L-tyrosylglycylglycine
    This reaction proceeds in the forward direction.
  • Met-enkephalin-Arg-Phe + H2O = L-arginyl-L-phenylalanine + Met-enkephalin
    This reaction proceeds in the forward direction.
  • neurotensin + H2O = neurotensin(1-11) + L-isoleucyl-L-leucine
    This reaction proceeds in the forward direction.
  • substance P + H2O = substance P(1-8) + Gly-L-Leu-L-Met-NH2
    This reaction proceeds in the forward direction.
  • substance P + H2O = substance P(1-9) + L-Leu-L-Met-NH2
    This reaction proceeds in the forward direction.
  • substance P + H2O = L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2 + substance P(1-6)
    This reaction proceeds in the forward direction.
  • Release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II.
    EC:3.4.15.1 (UniProtKB | ENZYME | Rhea)
  • angiotensin I + H2O = L-histidyl-L-leucine + angiotensin II
    This reaction proceeds in the forward direction.
    EC:3.4.15.1 (UniProtKB | ENZYME | Rhea)
  • bradykinin + H2O = L-Phe-L-Arg + bradykinin(1-7)
    This reaction proceeds in the forward direction.
  • goralatide + H2O = N-acetyl-L-seryl-L-aspartate + L-lysyl-L-proline
    This reaction proceeds in the forward direction.

Cofactor

Protein has several cofactor binding sites:
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per subunit.
chloride (UniProtKB | Rhea| CHEBI:17996 )

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site392Proton acceptor 1
Active site521Proton donor 1
Active site990Proton acceptor 2
Active site1119Proton donor 2

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentextracellular region
Cellular Componentmembrane
Molecular Functioncarboxypeptidase activity
Molecular Functionmetal ion binding
Molecular Functionmetallopeptidase activity
Molecular Functionpeptidyl-dipeptidase activity
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Angiotensin-converting enzyme
  • EC number

Gene names

    • Name
      ACE

Organism names

  • Taxonomic identifier
  • Strain
    • 17573
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Cercopithecinae > Macaca

Accessions

  • Primary accession
    F7F5D8

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Single-pass type I membrane protein
Cytoplasm
Secreted

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane1217-1236Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain, glycosylation, disulfide bond.

TypeIDPosition(s)Description
Signal1-30
ChainPRO_502384422831-1266Angiotensin-converting enzyme
Glycosylation39N-linked (GlcNAc...) asparagine
Glycosylation55N-linked (GlcNAc...) asparagine
Glycosylation75N-linked (GlcNAc...) asparagine
Glycosylation112N-linked (GlcNAc...) asparagine
Glycosylation147N-linked (GlcNAc...) asparagine
Disulfide bond158↔166
Glycosylation161N-linked (GlcNAc...) asparagine
Glycosylation319N-linked (GlcNAc...) asparagine
Disulfide bond360↔378
Glycosylation446N-linked (GlcNAc...) asparagine
Glycosylation510N-linked (GlcNAc...) asparagine
Disulfide bond546↔558
Glycosylation678N-linked (GlcNAc...) asparagine
Glycosylation696N-linked (GlcNAc...) (complex) asparagine
Glycosylation715N-linked (GlcNAc...) (complex) asparagine
Glycosylation761N-linked (GlcNAc...) asparagine; partial
Glycosylation943N-linked (GlcNAc...) asparagine; partial
Disulfide bond958↔976
Glycosylation1151N-linked (GlcNAc...) asparagine; partial

Keywords

Expression

Gene expression databases

Interaction

Subunit

Monomer and homodimer; homodimerizes following binding to an inhibitor. Interacts with calmodulin (CALM1, CALM2 or CALM3); interaction takes place in the cytoplasmic region and regulates phosphorylation and proteolytic cleavage.

Structure

Family & Domains

Sequence similarities

Belongs to the peptidase M2 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,266
  • Mass (Da)
    144,901
  • Last updated
    2019-12-11 v3
  • Checksum
    4B36590B6FBEDAEF
MGAASGRQGPGPLLQPLLLLLLLPPQPALALDPGLQPGNFSADEAGAQLFAQSYNSSAEQVLFQSVAASWAHDTNITAENARRQEEAALLSQEFAEAWGQKAKELYEPIWQNFTDPELRKIIGAVGTLGSANLPLAKRQQYNALLSNMSRIYSTAKVCLPNKTATCWSLDPDLTNILASSRSYAMLLFAWEGWHNAAGIPLKPLYEDFTALSNEAYKQDGFTDTGAYWRSWYNSPTFEDDLEHLYQQLEPLYLNLHAFVRRALHRRYGDRYINLRGPIPAHLLGDMWAQSWENIYDMVVPFPDKPNLDVTSTMLQQGWNATHMFRVAEEFFTSLELSPMPPEFWEGSMLEKPADGREVVCHASAWDFYNRKDFRIKQCTRVTMDQLSTVHHEMGHIQYYLQYKDLPVSLRGGANPGFHEAIGDVLALSVSTPAHLHKIGLLDHVTNDTESDINYLLKMALEKIAFLPFGYLVDQWRWGVFNGRTPPSHYNFDWWYLRTKYQGICPPVTRNETHFDAGAKFHVPNVTPYIRYFVSFVLQFQFHEALCKEAGYEGPLHQCDIYQSTKAGAKLRKVLQAGSSRPWQEVLKDMVGSDALDAQPLLNYFQPVTQWLQEQNRQNGEVLGWPEYQWRPPLPDNYPEGIDLVTDEAEASKFVEEYDRTSQVVWNEYAEANWNYNTNITTETSKILLQKNMQIANHTLKYGTQARRFDVNHFQNTTIKRIIKKVQDLERAALPAQELEEYNKILLDMETTYSVATVCHTNGSCLQLEPDLTNVMATSRKYEELLWAWEGWRDKAGRAILQFYPKYVELINQAARLNGYVDAGDSWRSMYETPSLEQDLERLFQELQPLYLNLHAYVRRALHRHYGAQHINLEGPIPAHLLGNMWAQTWSNIYDLVVPFPSAPSMDPTEAMLKQGWTPRRMFKEADDFFTSLGLLPVPPEFWNKSMLEKPTDGREVVCHASAWDFYNGKDFRIKQCTTVNLEDLVVAHHEMGHIQYFMQYKDLPVALREGANPGFHEAIGDVLALSVSTPKHLHSLNLLSSEGGSHEHDINFLMKMALDKIAFIPFSYLVDQWRWRVFDGSITKENYNQEWWSLRLKYQGLCPPVPRTQGDFDPGAKFHVPSSVPYIRTAMKLGFSRPWPEAMQLITGQPNMSASAMLSYFKPLLDWLRTENELHGEKLGWPQYNWTPNSARSEGPLPDSGRVSFLGLDLDAQQARVGQWLLLFLGIALLVATLGLSQRLFSIRHQSLHQHPQGPQFGSEVELRHS

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A1D5R9B8A0A1D5R9B8_MACMUACE1307
G7NJ76G7NJ76_MACMUACE342
A0A5K1VF83A0A5K1VF83_MACMUACE349
A0A5F8ANI1A0A5F8ANI1_MACMUACE452

Keywords

Genome annotation databases

Similar Proteins

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