F7EQS6 · F7EQS6_RAT

  • Protein
    Notch homolog 4, isoform CRA_b
  • Gene
    Notch4
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    5/5

Function

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Features

Showing features for binding site.

119612004006008001,0001,2001,4001,6001,800
TypeIDPosition(s)Description
Binding site452Ca2+ 1 (UniProtKB | ChEBI)
Binding site455Ca2+ 1 (UniProtKB | ChEBI)
Binding site472Ca2+ 2 (UniProtKB | ChEBI)
Binding site475Ca2+ 2 (UniProtKB | ChEBI)
Binding site489Ca2+ 2 (UniProtKB | ChEBI)
Binding site513Ca2+ 3 (UniProtKB | ChEBI)
Binding site527Ca2+ 3 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcell surface
Cellular Componentcytoplasmic vesicle
Cellular Componentendoplasmic reticulum
Cellular Componentnucleus
Cellular Componentplasma membrane
Molecular Functioncalcium ion binding
Molecular Functioncis-regulatory region sequence-specific DNA binding
Molecular FunctionDNA-binding transcription activator activity, RNA polymerase II-specific
Molecular FunctionNotch binding
Molecular Functionsignaling receptor activity
Biological Processbranching involved in blood vessel morphogenesis
Biological Processendothelial cell differentiation
Biological Processendothelial cell morphogenesis
Biological Processepithelial to mesenchymal transition
Biological Processluteolysis
Biological Processmammary gland development
Biological Processmorphogenesis of a branching structure
Biological Processnegative regulation of cell adhesion molecule production
Biological Processnegative regulation of cell-cell adhesion mediated by cadherin
Biological Processnegative regulation of endothelial cell differentiation
Biological Processnegative regulation of Notch signaling pathway
Biological Processnegative regulation of transcription by RNA polymerase II
Biological ProcessNotch signaling pathway
Biological Processpositive regulation of angiogenesis
Biological Processpositive regulation of aorta morphogenesis
Biological Processpositive regulation of smooth muscle cell differentiation
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processregulation of Notch signaling pathway
Biological Processregulation of protein localization
Biological Processregulation of protein processing
Biological Processvasculature development
Biological Processvenous blood vessel morphogenesis

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • Notch homolog 4, isoform CRA_b

Gene names

    • Name
      Notch4
    • ORF names
      rCG_38227

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • BN
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    F7EQS6

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Single-pass type I membrane protein
Nucleus

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane1403-1421Helical
Transmembrane1441-1464Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

TypeIDPosition(s)Description
Signal1-20
ChainPRO_504036546521-1961
Disulfide bond50↔59
Disulfide bond102↔111
Disulfide bond142↔151
Disulfide bond179↔188
Disulfide bond219↔228
Disulfide bond261↔270
Disulfide bond299↔308
Disulfide bond340↔349
Disulfide bond378↔387
Disulfide bond398↔415
Disulfide bond417↔426
Disulfide bond433↔449
Disulfide bond443↔458
Disulfide bond460↔469
Disulfide bond476↔487
Disulfide bond481↔496
Disulfide bond498↔507
Disulfide bond514↔525
Disulfide bond519↔534
Disulfide bond536↔545
Disulfide bond574↔583
Disulfide bond612↔621
Disulfide bond714↔723
Disulfide bond752↔761
Disulfide bond790↔799
Disulfide bond829↔838
Disulfide bond867↔876
Disulfide bond914↔923
Disulfide bond952↔961
Disulfide bond990↔999
Disulfide bond1011↔1028
Disulfide bond1030↔1039
Disulfide bond1071↔1080
Disulfide bond1112↔1121
Disulfide bond1157↔1166

Keywords

Structure

3D structure databases

Family & Domains

Features

Showing features for domain, region, compositional bias, repeat.

TypeIDPosition(s)Description
Domain21-60EGF-like
Domain61-112EGF-like
Domain115-152EGF-like
Domain153-189EGF-like
Domain191-229EGF-like
Domain231-271EGF-like
Domain273-309EGF-like
Domain311-350EGF-like
Domain352-388EGF-like
Domain389-427EGF-like
Domain429-470EGF-like
Domain472-508EGF-like
Domain510-546EGF-like
Domain548-584EGF-like
Domain586-622EGF-like
Domain688-724EGF-like
Domain726-762EGF-like
Domain764-800EGF-like
Domain803-839EGF-like
Domain841-877EGF-like
Domain889-924EGF-like
Domain926-962EGF-like
Domain964-1000EGF-like
Domain1002-1040EGF-like
Domain1042-1081EGF-like
Domain1083-1122EGF-like
Domain1126-1167EGF-like
Domain1166-1209LNR
Domain1210-1241LNR
Domain1247-1287LNR
Region1342-1371Disordered
Compositional bias1353-1370Polar residues
Repeat1625-1657ANK
Repeat1658-1679ANK
Repeat1692-1724ANK
Repeat1725-1757ANK
Repeat1758-1790ANK
Region1874-1904Disordered
Compositional bias1890-1904Basic and acidic residues
Region1922-1961Disordered

Sequence similarities

Belongs to the NOTCH family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,961
  • Mass (Da)
    206,076
  • Last updated
    2023-09-13 v1
  • Checksum
    5B1034E29EE07A3C
MQRQWLLLLLLPLSFPVILTRELLCGGSPEPCANGGTCLRLSQGQGTCQCAPGFLGETCQFPDPCWDTQLCENGGSCQALLPTAPSSHSPTSPLTPHFSCTCPSGFTGDRCQSPLEELCPPSFCSNGGHCSVQVSGRPQCSCEPGWTGEQCQLRDFCSANPCANGGVCLATYPQIQCRCPTGFEGHICERDVNECFLEPGPCPRGTSCHNTLGSFQCLCPVGQEGPQCKLRKGACLPGTCLNGGTCQLVPEGDTTFHLCLCPPGFTGLNCEMNPDDCVRNQCQNGATCQDGLGTYTCLCPKTWKGWDCSEDIDECEAQGPPRCRNGGTCQNSAGGFHCVCVSGWGGEGCDENLDDCAAATCALGSTCIDRVGSFSCLCPPGRTGLLCHLEDMCLRQPCHVNAQCSTNPLTGSTLCICQPGYSGPTCHQDLDECQMAQQGPSPCEHGGSCINTPGSFNCLCLPGYTGSRCEADHNECLSQPCHPGSTCLDLLATFQCLCPPGLEGRLCEVEINECASNPCLNQAACHDQLNGFLCLCLPGFTGARCEKDMDECSSAPCANGGHCQDQPGAFHCECLPGFEGPRCETEADECRSDPCPVGASCLDLPGAFLCLCRPGFTGQLCEVPLCSPILCQPGQQCQDQEHRAPCLCPDGSPGCVPAEDDCPCHHGHCQRSLCVCNEGWTGPECETELGGCLSTPCAHGGTCHPQPSGYNCSCLAGYTGLTCSEEITACHSGPCLNGGSCSIHPEGYSCTCPPSHTGPHCQTAVDHCASASCLNGGTCMSKPGTFFCHCATGFQGLHCEKKIHPSCADNPCRNKATCQDTPRGARCLCSPGYTGSSCQTLIDLCARKPCPHTARCLQSGPSFHCLCHQGWTGSLCDLPLSCQAAAMSQGVEISNLCQNGGLCIDTGSSYFCRCPPGFEGKLCQDTVNPCTSKPCLHGATCVPQPNGYVCQCAPGYEGQNCSKVHDACQSGPCHNHGTCTPRPGGFHCACPPGFVGLRCEGDVDECLDRPCHPSGTASCHSLANAFYCQCLPGHTGQRCEVEMDLCQSQPCSNGGSCEVTTGPPPGFTCRCPEGFEGPTCSRKAPACGNHHCHNGGLCLPSPKPGSPPLCACLSGFGGPDCLTPPAPPGCGPPSPCMHNGSCTETPGLGNPGFQCTCPPDSPGPRCQRPGANGCEGRGGDGACDAGCSGPGGDWDGGDCSLGVPDPWKGCPPHSQCWLLFRDGRCHPQCDSEECLFDGYDCEIPPTCTPAYDQYCRDHFHNGHCEKGCNNAQCGWDGGDCRPEGDDSEGGPSLALLVVLSPPALDQQLLALARVLSLTLRVGLWVRKDSEGRNMVFPYPGTRAKEELSGTRDSSSWERQAPHTQTPGKETESLGAGFVVVMGVDLSRCGPEHPASRCPRDSGLLLRFLAAMAAVGALEPLLPGPLLAAHPQAGTGSPATRLPWPILCSPVVGVLLLALGALLVLQLIRRRRREHGALWLPPGFIRRPQTQQAPHRRRPPLGEDNIGLKALKPEAEVDEDGVVMCSGPEEGEAEKTASASRCQLWPLRSGCEGLPQAVMLTPPQECESELPDSDTCGPDGVTPLMSAVFCGGVQSTTVQRLGLGNPEPWEPLLDRGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHTAVAADAREVCQLLLASRQTAVDARTDDGTTPLMLAARLAVEDLVEELIAARADVGARDKRGKTALHWAAAVNNARAARCLLQTGADKDAQDSREQTPLFLAAREGAVEVAQLLLEIGAARGLRDQAGLAPADVARQRSHWDLLTLLEGAGPITQEARSHARNTPGGGAAPRCRTLSAGARPRGGGACLQARTWSVDLGARRGAVYARCRSRSGGSGGPSMRGRRLSADSRGRRGARVSQDDWPRDWVALEACGSACSAPIPPPSLTPSPERGSPQVSWGLPVHQEVPLNSGGRNQN

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1353-1370Polar residues
Compositional bias1890-1904Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CH474121
EMBL· GenBank· DDBJ
EDL83377.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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