F7EQS6 · F7EQS6_RAT
- ProteinNotch homolog 4, isoform CRA_b
- GeneNotch4
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1961 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 452 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 455 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 472 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 475 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 489 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 513 | Ca2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 527 | Ca2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: D |
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionF7EQS6
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 1403-1421 | Helical | ||||
Sequence: LLLRFLAAMAAVGALEPLL | ||||||
Transmembrane | 1441-1464 | Helical | ||||
Sequence: LPWPILCSPVVGVLLLALGALLVL |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-20 | |||||
Sequence: MQRQWLLLLLLPLSFPVILT | ||||||
Chain | PRO_5040365465 | 21-1961 | ||||
Sequence: RELLCGGSPEPCANGGTCLRLSQGQGTCQCAPGFLGETCQFPDPCWDTQLCENGGSCQALLPTAPSSHSPTSPLTPHFSCTCPSGFTGDRCQSPLEELCPPSFCSNGGHCSVQVSGRPQCSCEPGWTGEQCQLRDFCSANPCANGGVCLATYPQIQCRCPTGFEGHICERDVNECFLEPGPCPRGTSCHNTLGSFQCLCPVGQEGPQCKLRKGACLPGTCLNGGTCQLVPEGDTTFHLCLCPPGFTGLNCEMNPDDCVRNQCQNGATCQDGLGTYTCLCPKTWKGWDCSEDIDECEAQGPPRCRNGGTCQNSAGGFHCVCVSGWGGEGCDENLDDCAAATCALGSTCIDRVGSFSCLCPPGRTGLLCHLEDMCLRQPCHVNAQCSTNPLTGSTLCICQPGYSGPTCHQDLDECQMAQQGPSPCEHGGSCINTPGSFNCLCLPGYTGSRCEADHNECLSQPCHPGSTCLDLLATFQCLCPPGLEGRLCEVEINECASNPCLNQAACHDQLNGFLCLCLPGFTGARCEKDMDECSSAPCANGGHCQDQPGAFHCECLPGFEGPRCETEADECRSDPCPVGASCLDLPGAFLCLCRPGFTGQLCEVPLCSPILCQPGQQCQDQEHRAPCLCPDGSPGCVPAEDDCPCHHGHCQRSLCVCNEGWTGPECETELGGCLSTPCAHGGTCHPQPSGYNCSCLAGYTGLTCSEEITACHSGPCLNGGSCSIHPEGYSCTCPPSHTGPHCQTAVDHCASASCLNGGTCMSKPGTFFCHCATGFQGLHCEKKIHPSCADNPCRNKATCQDTPRGARCLCSPGYTGSSCQTLIDLCARKPCPHTARCLQSGPSFHCLCHQGWTGSLCDLPLSCQAAAMSQGVEISNLCQNGGLCIDTGSSYFCRCPPGFEGKLCQDTVNPCTSKPCLHGATCVPQPNGYVCQCAPGYEGQNCSKVHDACQSGPCHNHGTCTPRPGGFHCACPPGFVGLRCEGDVDECLDRPCHPSGTASCHSLANAFYCQCLPGHTGQRCEVEMDLCQSQPCSNGGSCEVTTGPPPGFTCRCPEGFEGPTCSRKAPACGNHHCHNGGLCLPSPKPGSPPLCACLSGFGGPDCLTPPAPPGCGPPSPCMHNGSCTETPGLGNPGFQCTCPPDSPGPRCQRPGANGCEGRGGDGACDAGCSGPGGDWDGGDCSLGVPDPWKGCPPHSQCWLLFRDGRCHPQCDSEECLFDGYDCEIPPTCTPAYDQYCRDHFHNGHCEKGCNNAQCGWDGGDCRPEGDDSEGGPSLALLVVLSPPALDQQLLALARVLSLTLRVGLWVRKDSEGRNMVFPYPGTRAKEELSGTRDSSSWERQAPHTQTPGKETESLGAGFVVVMGVDLSRCGPEHPASRCPRDSGLLLRFLAAMAAVGALEPLLPGPLLAAHPQAGTGSPATRLPWPILCSPVVGVLLLALGALLVLQLIRRRRREHGALWLPPGFIRRPQTQQAPHRRRPPLGEDNIGLKALKPEAEVDEDGVVMCSGPEEGEAEKTASASRCQLWPLRSGCEGLPQAVMLTPPQECESELPDSDTCGPDGVTPLMSAVFCGGVQSTTVQRLGLGNPEPWEPLLDRGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHTAVAADAREVCQLLLASRQTAVDARTDDGTTPLMLAARLAVEDLVEELIAARADVGARDKRGKTALHWAAAVNNARAARCLLQTGADKDAQDSREQTPLFLAAREGAVEVAQLLLEIGAARGLRDQAGLAPADVARQRSHWDLLTLLEGAGPITQEARSHARNTPGGGAAPRCRTLSAGARPRGGGACLQARTWSVDLGARRGAVYARCRSRSGGSGGPSMRGRRLSADSRGRRGARVSQDDWPRDWVALEACGSACSAPIPPPSLTPSPERGSPQVSWGLPVHQEVPLNSGGRNQN | ||||||
Disulfide bond | 50↔59 | |||||
Sequence: CAPGFLGETC | ||||||
Disulfide bond | 102↔111 | |||||
Sequence: CPSGFTGDRC | ||||||
Disulfide bond | 142↔151 | |||||
Sequence: CEPGWTGEQC | ||||||
Disulfide bond | 179↔188 | |||||
Sequence: CPTGFEGHIC | ||||||
Disulfide bond | 219↔228 | |||||
Sequence: CPVGQEGPQC | ||||||
Disulfide bond | 261↔270 | |||||
Sequence: CPPGFTGLNC | ||||||
Disulfide bond | 299↔308 | |||||
Sequence: CPKTWKGWDC | ||||||
Disulfide bond | 340↔349 | |||||
Sequence: CVSGWGGEGC | ||||||
Disulfide bond | 378↔387 | |||||
Sequence: CPPGRTGLLC | ||||||
Disulfide bond | 398↔415 | |||||
Sequence: CHVNAQCSTNPLTGSTLC | ||||||
Disulfide bond | 417↔426 | |||||
Sequence: CQPGYSGPTC | ||||||
Disulfide bond | 433↔449 | |||||
Sequence: CQMAQQGPSPCEHGGSC | ||||||
Disulfide bond | 443↔458 | |||||
Sequence: CEHGGSCINTPGSFNC | ||||||
Disulfide bond | 460↔469 | |||||
Sequence: CLPGYTGSRC | ||||||
Disulfide bond | 476↔487 | |||||
Sequence: CLSQPCHPGSTC | ||||||
Disulfide bond | 481↔496 | |||||
Sequence: CHPGSTCLDLLATFQC | ||||||
Disulfide bond | 498↔507 | |||||
Sequence: CPPGLEGRLC | ||||||
Disulfide bond | 514↔525 | |||||
Sequence: CASNPCLNQAAC | ||||||
Disulfide bond | 519↔534 | |||||
Sequence: CLNQAACHDQLNGFLC | ||||||
Disulfide bond | 536↔545 | |||||
Sequence: CLPGFTGARC | ||||||
Disulfide bond | 574↔583 | |||||
Sequence: CLPGFEGPRC | ||||||
Disulfide bond | 612↔621 | |||||
Sequence: CRPGFTGQLC | ||||||
Disulfide bond | 714↔723 | |||||
Sequence: CLAGYTGLTC | ||||||
Disulfide bond | 752↔761 | |||||
Sequence: CPPSHTGPHC | ||||||
Disulfide bond | 790↔799 | |||||
Sequence: CATGFQGLHC | ||||||
Disulfide bond | 829↔838 | |||||
Sequence: CSPGYTGSSC | ||||||
Disulfide bond | 867↔876 | |||||
Sequence: CHQGWTGSLC | ||||||
Disulfide bond | 914↔923 | |||||
Sequence: CPPGFEGKLC | ||||||
Disulfide bond | 952↔961 | |||||
Sequence: CAPGYEGQNC | ||||||
Disulfide bond | 990↔999 | |||||
Sequence: CPPGFVGLRC | ||||||
Disulfide bond | 1011↔1028 | |||||
Sequence: CHPSGTASCHSLANAFYC | ||||||
Disulfide bond | 1030↔1039 | |||||
Sequence: CLPGHTGQRC | ||||||
Disulfide bond | 1071↔1080 | |||||
Sequence: CPEGFEGPTC | ||||||
Disulfide bond | 1112↔1121 | |||||
Sequence: CLSGFGGPDC | ||||||
Disulfide bond | 1157↔1166 | |||||
Sequence: CPPDSPGPRC |
Keywords
- PTM
Family & Domains
Features
Showing features for domain, region, compositional bias, repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 21-60 | EGF-like | ||||
Sequence: RELLCGGSPEPCANGGTCLRLSQGQGTCQCAPGFLGETCQ | ||||||
Domain | 61-112 | EGF-like | ||||
Sequence: FPDPCWDTQLCENGGSCQALLPTAPSSHSPTSPLTPHFSCTCPSGFTGDRCQ | ||||||
Domain | 115-152 | EGF-like | ||||
Sequence: LEELCPPSFCSNGGHCSVQVSGRPQCSCEPGWTGEQCQ | ||||||
Domain | 153-189 | EGF-like | ||||
Sequence: LRDFCSANPCANGGVCLATYPQIQCRCPTGFEGHICE | ||||||
Domain | 191-229 | EGF-like | ||||
Sequence: DVNECFLEPGPCPRGTSCHNTLGSFQCLCPVGQEGPQCK | ||||||
Domain | 231-271 | EGF-like | ||||
Sequence: RKGACLPGTCLNGGTCQLVPEGDTTFHLCLCPPGFTGLNCE | ||||||
Domain | 273-309 | EGF-like | ||||
Sequence: NPDDCVRNQCQNGATCQDGLGTYTCLCPKTWKGWDCS | ||||||
Domain | 311-350 | EGF-like | ||||
Sequence: DIDECEAQGPPRCRNGGTCQNSAGGFHCVCVSGWGGEGCD | ||||||
Domain | 352-388 | EGF-like | ||||
Sequence: NLDDCAAATCALGSTCIDRVGSFSCLCPPGRTGLLCH | ||||||
Domain | 389-427 | EGF-like | ||||
Sequence: LEDMCLRQPCHVNAQCSTNPLTGSTLCICQPGYSGPTCH | ||||||
Domain | 429-470 | EGF-like | ||||
Sequence: DLDECQMAQQGPSPCEHGGSCINTPGSFNCLCLPGYTGSRCE | ||||||
Domain | 472-508 | EGF-like | ||||
Sequence: DHNECLSQPCHPGSTCLDLLATFQCLCPPGLEGRLCE | ||||||
Domain | 510-546 | EGF-like | ||||
Sequence: EINECASNPCLNQAACHDQLNGFLCLCLPGFTGARCE | ||||||
Domain | 548-584 | EGF-like | ||||
Sequence: DMDECSSAPCANGGHCQDQPGAFHCECLPGFEGPRCE | ||||||
Domain | 586-622 | EGF-like | ||||
Sequence: EADECRSDPCPVGASCLDLPGAFLCLCRPGFTGQLCE | ||||||
Domain | 688-724 | EGF-like | ||||
Sequence: ELGGCLSTPCAHGGTCHPQPSGYNCSCLAGYTGLTCS | ||||||
Domain | 726-762 | EGF-like | ||||
Sequence: EITACHSGPCLNGGSCSIHPEGYSCTCPPSHTGPHCQ | ||||||
Domain | 764-800 | EGF-like | ||||
Sequence: AVDHCASASCLNGGTCMSKPGTFFCHCATGFQGLHCE | ||||||
Domain | 803-839 | EGF-like | ||||
Sequence: IHPSCADNPCRNKATCQDTPRGARCLCSPGYTGSSCQ | ||||||
Domain | 841-877 | EGF-like | ||||
Sequence: LIDLCARKPCPHTARCLQSGPSFHCLCHQGWTGSLCD | ||||||
Domain | 889-924 | EGF-like | ||||
Sequence: QGVEISNLCQNGGLCIDTGSSYFCRCPPGFEGKLCQ | ||||||
Domain | 926-962 | EGF-like | ||||
Sequence: TVNPCTSKPCLHGATCVPQPNGYVCQCAPGYEGQNCS | ||||||
Domain | 964-1000 | EGF-like | ||||
Sequence: VHDACQSGPCHNHGTCTPRPGGFHCACPPGFVGLRCE | ||||||
Domain | 1002-1040 | EGF-like | ||||
Sequence: DVDECLDRPCHPSGTASCHSLANAFYCQCLPGHTGQRCE | ||||||
Domain | 1042-1081 | EGF-like | ||||
Sequence: EMDLCQSQPCSNGGSCEVTTGPPPGFTCRCPEGFEGPTCS | ||||||
Domain | 1083-1122 | EGF-like | ||||
Sequence: KAPACGNHHCHNGGLCLPSPKPGSPPLCACLSGFGGPDCL | ||||||
Domain | 1126-1167 | EGF-like | ||||
Sequence: APPGCGPPSPCMHNGSCTETPGLGNPGFQCTCPPDSPGPRCQ | ||||||
Domain | 1166-1209 | LNR | ||||
Sequence: CQRPGANGCEGRGGDGACDAGCSGPGGDWDGGDCSLGVPDPWKG | ||||||
Domain | 1210-1241 | LNR | ||||
Sequence: CPPHSQCWLLFRDGRCHPQCDSEECLFDGYDC | ||||||
Domain | 1247-1287 | LNR | ||||
Sequence: CTPAYDQYCRDHFHNGHCEKGCNNAQCGWDGGDCRPEGDDS | ||||||
Region | 1342-1371 | Disordered | ||||
Sequence: RAKEELSGTRDSSSWERQAPHTQTPGKETE | ||||||
Compositional bias | 1353-1370 | Polar residues | ||||
Sequence: SSSWERQAPHTQTPGKET | ||||||
Repeat | 1625-1657 | ANK | ||||
Sequence: TGETPLHLAARFSRPTAARRLLEAGANPNQPDR | ||||||
Repeat | 1658-1679 | ANK | ||||
Sequence: AGRTPLHTAVAADAREVCQLLL | ||||||
Repeat | 1692-1724 | ANK | ||||
Sequence: DGTTPLMLAARLAVEDLVEELIAARADVGARDK | ||||||
Repeat | 1725-1757 | ANK | ||||
Sequence: RGKTALHWAAAVNNARAARCLLQTGADKDAQDS | ||||||
Repeat | 1758-1790 | ANK | ||||
Sequence: REQTPLFLAAREGAVEVAQLLLEIGAARGLRDQ | ||||||
Region | 1874-1904 | Disordered | ||||
Sequence: RSRSGGSGGPSMRGRRLSADSRGRRGARVSQ | ||||||
Compositional bias | 1890-1904 | Basic and acidic residues | ||||
Sequence: LSADSRGRRGARVSQ | ||||||
Region | 1922-1961 | Disordered | ||||
Sequence: SAPIPPPSLTPSPERGSPQVSWGLPVHQEVPLNSGGRNQN |
Sequence similarities
Belongs to the NOTCH family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,961
- Mass (Da)206,076
- Last updated2023-09-13 v1
- Checksum5B1034E29EE07A3C
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1353-1370 | Polar residues | ||||
Sequence: SSSWERQAPHTQTPGKET | ||||||
Compositional bias | 1890-1904 | Basic and acidic residues | ||||
Sequence: LSADSRGRRGARVSQ |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CH474121 EMBL· GenBank· DDBJ | EDL83377.1 EMBL· GenBank· DDBJ | Genomic DNA |