F7EFW1 · F7EFW1_MACMU
- ProteinEctonucleoside triphosphate diphosphohydrolase 1
- GeneENTPD1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids517 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
function
Catalyzes the hydrolysis of both di- and triphosphate nucleotides (NDPs and NTPs) and hydrolyze NTPs to nucleotide monophosphates (NMPs) in two distinct successive phosphate-releasing steps, with NDPs as intermediates and participates in the regulation of extracellular levels of nucleotides. By hydrolyzing proinflammatory ATP and platelet-activating ADP to AMP, it blocks platelet aggregation and supports blood flow.
Catalytic activity
- ITP + 2 H2O = IMP + 2 phosphate + 2 H+This reaction proceeds in the forward direction.
- UTP + 2 H2O = UMP + 2 phosphate + 2 H+This reaction proceeds in the forward direction.
- ADP + H2O = AMP + phosphate + H+This reaction proceeds in the forward direction.
- ATP + 2 H2O = AMP + 2 phosphate + 2 H+This reaction proceeds in the forward direction.
- ATP + H2O = ADP + phosphate + H+This reaction proceeds in the forward direction.
- CDP + H2O = CMP + phosphate + H+This reaction proceeds in the forward direction.
- CTP + 2 H2O = CMP + 2 phosphate + 2 H+This reaction proceeds in the forward direction.
- CTP + H2O = CDP + phosphate + H+This reaction proceeds in the forward direction.
- GDP + H2O = GMP + phosphate + H+This reaction proceeds in the forward direction.
- GTP + 2 H2O = GMP + 2 phosphate + 2 H+This reaction proceeds in the forward direction.
- GTP + H2O = GDP + phosphate + H+This reaction proceeds in the forward direction.
- IDP + H2O = IMP + phosphate + H+This reaction proceeds in the forward direction.
- ITP + H2O = IDP + phosphate + H+This reaction proceeds in the forward direction.
- UDP + H2O = UMP + phosphate + H+This reaction proceeds in the forward direction.
- UTP + H2O = UDP + phosphate + H+This reaction proceeds in the forward direction.
- a ribonucleoside 5'-diphosphate + H2O = a ribonucleoside 5'-phosphate + phosphate + H+This reaction proceeds in the forward direction.
- a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H+This reaction proceeds in the forward direction.
Cofactor
Protein has several cofactor binding sites:
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 181 | Proton acceptor | |||
Binding site | 223-227 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Molecular Function | ATP binding | |
Molecular Function | hydrolase activity |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameEctonucleoside triphosphate diphosphohydrolase 1
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Cercopithecinae > Macaca
Accessions
- Primary accessionF7EFW1
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 24-44 | Helical | |||
Transmembrane | 484-506 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Expression
Gene expression databases
Interaction
Subunit
Homodimer; disulfide-linked.
Structure
Sequence
- Sequence statusComplete
- Length517
- Mass (Da)58,690
- Last updated2019-12-11 v3
- Checksum2104A917593DA735
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A5K1VEJ0 | A0A5K1VEJ0_MACMU | ENTPD1 | 510 | ||
A0A5F8ARL5 | A0A5F8ARL5_MACMU | ENTPD1 | 522 |
Keywords
- Technical term