F7EFW1 · F7EFW1_MACMU

Function

function

Catalyzes the hydrolysis of both di- and triphosphate nucleotides (NDPs and NTPs) and hydrolyze NTPs to nucleotide monophosphates (NMPs) in two distinct successive phosphate-releasing steps, with NDPs as intermediates and participates in the regulation of extracellular levels of nucleotides. By hydrolyzing proinflammatory ATP and platelet-activating ADP to AMP, it blocks platelet aggregation and supports blood flow.

Catalytic activity

  • ITP + 2 H2O = IMP + 2 phosphate + 2 H+
    This reaction proceeds in the forward direction.
  • UTP + 2 H2O = UMP + 2 phosphate + 2 H+
    This reaction proceeds in the forward direction.
  • ADP + H2O = AMP + phosphate + H+
    This reaction proceeds in the forward direction.
  • ATP + 2 H2O = AMP + 2 phosphate + 2 H+
    This reaction proceeds in the forward direction.
  • ATP + H2O = ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • CDP + H2O = CMP + phosphate + H+
    This reaction proceeds in the forward direction.
  • CTP + 2 H2O = CMP + 2 phosphate + 2 H+
    This reaction proceeds in the forward direction.
  • CTP + H2O = CDP + phosphate + H+
    This reaction proceeds in the forward direction.
  • GDP + H2O = GMP + phosphate + H+
    This reaction proceeds in the forward direction.
  • GTP + 2 H2O = GMP + 2 phosphate + 2 H+
    This reaction proceeds in the forward direction.
  • GTP + H2O = GDP + phosphate + H+
    This reaction proceeds in the forward direction.
  • IDP + H2O = IMP + phosphate + H+
    This reaction proceeds in the forward direction.
  • ITP + H2O = IDP + phosphate + H+
    This reaction proceeds in the forward direction.
  • UDP + H2O = UMP + phosphate + H+
    This reaction proceeds in the forward direction.
  • UTP + H2O = UDP + phosphate + H+
    This reaction proceeds in the forward direction.
  • a ribonucleoside 5'-diphosphate + H2O = a ribonucleoside 5'-phosphate + phosphate + H+
    This reaction proceeds in the forward direction.
  • a ribonucleoside 5'-triphosphate + 2 H2O = a ribonucleoside 5'-phosphate + 2 phosphate + 2 H+
    This reaction proceeds in the forward direction.
    EC:3.6.1.5 (UniProtKB | ENZYME | Rhea)
  • a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H+
    This reaction proceeds in the forward direction.

Cofactor

Protein has several cofactor binding sites:
Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for active site, binding site.

Type
IDPosition(s)Description
Active site181Proton acceptor
Binding site223-227ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmembrane
Molecular FunctionATP binding
Molecular Functionhydrolase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ectonucleoside triphosphate diphosphohydrolase 1
  • EC number
  • Alternative names
    • ATP diphosphohydrolase
    • Ecto-ATP diphosphohydrolase 1
    • Ecto-apyrase
    • Lymphoid cell activation antigen
    • Nucleoside triphosphate diphosphohydrolase 1

Gene names

    • Name
      ENTPD1

Organism names

  • Taxonomic identifier
  • Strain
    • 17573
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Cercopithecinae > Macaca

Accessions

  • Primary accession
    F7EFW1
  • Secondary accessions
    • H9EUS6

Proteomes

Organism-specific databases

Subcellular Location

Membrane, caveola
Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane24-44Helical
Transmembrane484-506Helical

Keywords

  • Cellular component

PTM/Processing

Keywords

Expression

Gene expression databases

Interaction

Subunit

Homodimer; disulfide-linked.

Family & Domains

Sequence similarities

Belongs to the GDA1/CD39 NTPase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    517
  • Mass (Da)
    58,690
  • Last updated
    2019-12-11 v3
  • Checksum
    2104A917593DA735
MKGTKDLTSQQKESNVKTFCSKNILAILGFSSIIAVIALLAVGLTQNKALPENIKYGIVLDAGSSHTSLYIYKWPAEKENDTGVVHQVEECRVKGPGISKYVQKVNEIGIYLTDCMERAREVIPRSQHQETPVYLGATAGMRLLRMESEELADRVLDVVERSLSNYPFDFQGARIITGQEEGAYGWITINYLLGKFSQKTRWFSIVPYETNNQETFGALDLGGASTQITFVPQNQTTESPDNALQFRLYGKDYNVYTHSFLCYGKDQALWQKLAKDIQVASNEILRDPCFHPGYKKVVNVSDLYKTPCTKRFEMTLPFQQFEIQGIGNYQQCHQSVLELFNTSYCPYSQCAFNGIFLPPLQGDFGAFSAFYFVMNFLNLTSEKVSQEKVTEMMKKFCSQPWEEIKTSYAGVKEKYLSEYCFSGTYILSLLLQGYHFTADSWEHIHFIGKIQGSDAGWTLGYMLNLTNMIPAEQPLSTPLSHSTYVFLMVLFSLVLVIVAIIGLLIFHKPSYFWKDMV

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A5K1VEJ0A0A5K1VEJ0_MACMUENTPD1510
A0A5F8ARL5A0A5F8ARL5_MACMUENTPD1522

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

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