F7E8M5 · F7E8M5_CALJA

Function

Catalytic activity

  • 3beta,7alpha-dihydroxyandrost-5-en-17-one + NADP+ = 3beta-hydroxy-5-androstene-7,17-dione + NADPH + H+
    This reaction proceeds in the forward direction.
  • 3beta-hydroxy-5-androstene-7,17-dione + NADPH + H+ = 3beta,7beta-dihydroxyandrost-5-en-17-one + NADP+
    This reaction proceeds in the forward direction.
  • 3beta-hydroxy-5alpha-androstane-7,17-dione + NADPH + H+ = 3beta,7beta-dihydroxy-5alpha-androstan-17-one + NADP+
    This reaction proceeds in the forward direction.
  • 7-oxocholesterol + NADPH + H+ = 7beta-hydroxycholesterol + NADP+
    This reaction proceeds in the forward direction.
  • 7-oxolithocholate + NADPH + H+ = ursodeoxycholate + NADP+
    This reaction proceeds in the forward direction.
  • 7-oxopregnenolone + NADPH + H+ = 7beta-hydroxypregnenolone + NADP+
    This reaction proceeds in the forward direction.
  • taurochenodeoxycholate + NADP+ = 7-oxotaurolithocholate + NADPH + H+
    This reaction proceeds in the backward direction.
  • tauroursodeoxycholate + NADP+ = 7-oxotaurolithocholate + NADPH + H+
    This reaction proceeds in the backward direction.
  • a 7beta-hydroxysteroid + NADP+ = a 7-oxosteroid + NADPH + H+
    This reaction proceeds in the backward direction.
    EC:1.1.1.201 (UniProtKB | ENZYME | Rhea)
  • an 11beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+
    This reaction proceeds in the forward
    and the backward
    directions.
    EC:1.1.1.146 (UniProtKB | ENZYME | Rhea)
  • chenodeoxycholate + NADP+ = 7-oxolithocholate + NADPH + H+
    This reaction proceeds in the backward direction.
  • corticosterone + NADP+ = 11-dehydrocorticosterone + NADPH + H+
    This reaction proceeds in the forward
    and the backward
    directions.
  • glycochenodeoxycholate + NADP+ = 7-oxoglycolithocholate + NADPH + H+
    This reaction proceeds in the backward direction.
  • glycoursodeoxycholate + NADP+ = 7-oxoglycolithocholate + NADPH + H+
    This reaction proceeds in the backward direction.

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Function11-beta-hydroxysteroid dehydrogenase (NADP+) activity
Molecular FunctionNADP binding
Molecular Functionprotein homodimerization activity
Molecular Functionsteroid binding
Biological Processlung development
Biological Processsteroid catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    11-beta-hydroxysteroid dehydrogenase 1
  • EC number
  • Alternative names
    • 7-oxosteroid reductase
    • Corticosteroid 11-beta-dehydrogenase isozyme 1

Gene names

    • Name
      HSD11B1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Platyrrhini > Cebidae > Callitrichinae > Callithrix > Callithrix

Accessions

  • Primary accession
    F7E8M5

Proteomes

Subcellular Location

Endoplasmic reticulum membrane
; Single-pass type II membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane7-24Helical

Keywords

Expression

Gene expression databases

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    291
  • Mass (Da)
    32,191
  • Last updated
    2011-07-27 v1
  • Checksum
    8A1CA40D751FB440
MAFMKKHLLPILGLFMAYYYYSAYEEFRPEMLQGKKVIVTGASKGIGREIAHHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMAFAEQFVAQAGKLMGGLDMLILNHITNTSLNFFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVIVSSVAGKVAYPMISAYSASKFALDGFFSSIRKEYLMAKVNVSITLCVLGLIDTDTAMKAVSGIINMQAAPKEECALEIIKGGVLRQEEVYYDSSLWTTLLLRNPSRKILEFLRSTSYSTDRLIN

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GAMT01006462
EMBL· GenBank· DDBJ
JAB05399.1
EMBL· GenBank· DDBJ
mRNA
GAMR01008781
EMBL· GenBank· DDBJ
JAB25151.1
EMBL· GenBank· DDBJ
mRNA
GAMP01006151
EMBL· GenBank· DDBJ
JAB46604.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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