F7E8M5 · F7E8M5_CALJA
- Protein11-beta-hydroxysteroid dehydrogenase 1
- GeneHSD11B1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids291 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
Catalytic activity
- 3beta,7alpha-dihydroxyandrost-5-en-17-one + NADP+ = 3beta-hydroxy-5-androstene-7,17-dione + NADPH + H+This reaction proceeds in the forward direction.
- 3beta-hydroxy-5-androstene-7,17-dione + NADPH + H+ = 3beta,7beta-dihydroxyandrost-5-en-17-one + NADP+This reaction proceeds in the forward direction.
- 3beta-hydroxy-5alpha-androstane-7,17-dione + NADPH + H+ = 3beta,7beta-dihydroxy-5alpha-androstan-17-one + NADP+This reaction proceeds in the forward direction.
- 7-oxocholesterol + NADPH + H+ = 7beta-hydroxycholesterol + NADP+This reaction proceeds in the forward direction.
- 7-oxolithocholate + NADPH + H+ = ursodeoxycholate + NADP+This reaction proceeds in the forward direction.
- 7-oxopregnenolone + NADPH + H+ = 7beta-hydroxypregnenolone + NADP+This reaction proceeds in the forward direction.
- taurochenodeoxycholate + NADP+ = 7-oxotaurolithocholate + NADPH + H+This reaction proceeds in the backward direction.
- tauroursodeoxycholate + NADP+ = 7-oxotaurolithocholate + NADPH + H+This reaction proceeds in the backward direction.
- chenodeoxycholate + NADP+ = 7-oxolithocholate + NADPH + H+This reaction proceeds in the backward direction.
- corticosterone + NADP+ = 11-dehydrocorticosterone + NADPH + H+This reaction proceeds in the forward and the backward directions.
- glycochenodeoxycholate + NADP+ = 7-oxoglycolithocholate + NADPH + H+This reaction proceeds in the backward direction.
- glycoursodeoxycholate + NADP+ = 7-oxoglycolithocholate + NADPH + H+This reaction proceeds in the backward direction.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | 11-beta-hydroxysteroid dehydrogenase (NADP+) activity | |
Molecular Function | NADP binding | |
Molecular Function | protein homodimerization activity | |
Molecular Function | steroid binding | |
Biological Process | lung development | |
Biological Process | steroid catabolic process |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name11-beta-hydroxysteroid dehydrogenase 1
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Platyrrhini > Cebidae > Callitrichinae > Callithrix > Callithrix
Accessions
- Primary accessionF7E8M5
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Single-pass type II membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 7-24 | Helical | ||||
Sequence: HLLPILGLFMAYYYYSAY |
Keywords
- Cellular component
Expression
Gene expression databases
Interaction
Subunit
Homodimer.
Structure
Sequence
- Sequence statusComplete
- Length291
- Mass (Da)32,191
- Last updated2011-07-27 v1
- Checksum8A1CA40D751FB440
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
GAMT01006462 EMBL· GenBank· DDBJ | JAB05399.1 EMBL· GenBank· DDBJ | mRNA | ||
GAMR01008781 EMBL· GenBank· DDBJ | JAB25151.1 EMBL· GenBank· DDBJ | mRNA | ||
GAMP01006151 EMBL· GenBank· DDBJ | JAB46604.1 EMBL· GenBank· DDBJ | mRNA |