F7DJ58 · F7DJ58_MONDO

Function

function

Phosphatase which shows a preference for 4'-phosphopantetheine and its oxidatively damaged forms (sulfonate or S-sulfonate), providing strong indirect evidence that the phosphatase activity pre-empts damage in the coenzyme A (CoA) pathway. Hydrolyzing excess 4'-phosphopantetheine could constitute a directed overflow mechanism to prevent its oxidation to the S-sulfonate, sulfonate, or other forms. Hydrolyzing 4'-phosphopantetheine sulfonate or S-sulfonate would forestall their conversion to inactive forms of CoA and acyl carrier protein. May play a role in the physiological regulation of CoA intracellular levels.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Ni2+ (UniProtKB | Rhea| CHEBI:49786 )

Activity regulation

Activity is strongly promoted by Co2+, Ni2+, Mg2+ and Mn2+. Activity is inhibited by EDTA.

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionpantothenate kinase activity
Biological Processcoenzyme A biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    4'-phosphopantetheine phosphatase
  • EC number

Gene names

    • Name
      PANK4

Organism names

Accessions

  • Primary accession
    F7DJ58

Proteomes

Subcellular Location

Keywords

PTM/Processing

Keywords

Expression

Gene expression databases

Interaction

Subunit

Homodimer. Interacts with PKM.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain453-759Damage-control phosphatase ARMT1-like metal-binding

Sequence similarities

Belongs to the type II pantothenate kinase family.
In the N-terminal section; belongs to the type II pantothenate kinase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    773
  • Mass (Da)
    86,598
  • Last updated
    2013-01-09 v2
  • Checksum
    4E1FDF9FEDD79485
MAECGASGSGSSGDSLDKSITLPPDEIFRNLENAKRFAIDIGGSLTKLAYYSTVQHKVARVRSFDHSGKDAEQEHEPPYEISVQEEITARLHFIKFENTYIEACLDFIKDHLVNTETKVIQATGGGAYKFKDLIEEKLRLKVDKEDVMTCLIKGCNFVLKNIPHEAFMYQKDADPEFRFQTNHPNIFPYLLVNIGSGVSIVKVETEDKFEWIGGSSIGGGTFWGLGALLTKTKKFDELLHLASKGQHTNVDMLVRDVYGGAYQTLGLSGNLIASSFGKSATADKEFSKEDMSKSLLHMISNDIGQLACLYAKLHNLDRVYFGGFFIRGHPVTMRTITYSINFFSKGEVQALFLRHEGYLGAIGAFLKGAEQDNPNQYSWGENYAGSSGLMSTSPELFPMQRARSGTFDLLEMDRLERPLVNLPLLLDPSSYIPDTVDLTDDAMARKYWLTCFEEALDGVVNRAIASQPDAIDAAERAEKFRQKYWNKLQTLRHQPFAYGTLTVRSLLETREHCLNEFNFPDPYSKVKQRENGIALKCFQRVIRSLDSLGWEERQFALVKGLLAGNVFDWGAKAVSDVLESEPQFGFEEAKRKLQERPWLVDSYGEWLQRLKGPPHKCALIFADNSGIDIILGVFPFVRELLFRGTEVILACNSGPALNDVTYNESLIVAERIAAMDPLIQSALREDKLLLVQTGSSSPCLDLSRLDKGLAVLVRERSTDLVVIEGMGRAIHTNYHAALRCESLKLAVIKNSWLADRLGGRLFSVIFKYEVPAK

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A5F8GSP9A0A5F8GSP9_MONDOPANK4786

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

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