F7DJ58 · F7DJ58_MONDO
- Protein4'-phosphopantetheine phosphatase
- GenePANK4
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids773 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Phosphatase which shows a preference for 4'-phosphopantetheine and its oxidatively damaged forms (sulfonate or S-sulfonate), providing strong indirect evidence that the phosphatase activity pre-empts damage in the coenzyme A (CoA) pathway. Hydrolyzing excess 4'-phosphopantetheine could constitute a directed overflow mechanism to prevent its oxidation to the S-sulfonate, sulfonate, or other forms. Hydrolyzing 4'-phosphopantetheine sulfonate or S-sulfonate would forestall their conversion to inactive forms of CoA and acyl carrier protein. May play a role in the physiological regulation of CoA intracellular levels.
Catalytic activity
- (R)-4'-phospho-S-sulfopantetheine + H2O = (R)-S-sulfopantetheine + phosphateThis reaction proceeds in the forward direction.
- (R)-4'-phosphopantetheine + H2O = (R)-pantetheine + phosphateThis reaction proceeds in the forward direction.
- (R)-4'-phosphopantetheine sulfonate + H2O = (R)-pantetheine sulfonate + phosphateThis reaction proceeds in the forward direction.
Cofactor
Protein has several cofactor binding sites:
Activity regulation
Activity is strongly promoted by Co2+, Ni2+, Mg2+ and Mn2+. Activity is inhibited by EDTA.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | pantothenate kinase activity | |
Biological Process | coenzyme A biosynthetic process |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name4'-phosphopantetheine phosphatase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Metatheria > Didelphimorphia > Didelphidae > Monodelphis
Accessions
- Primary accessionF7DJ58
Proteomes
Subcellular Location
PTM/Processing
Keywords
- PTM
Expression
Gene expression databases
Interaction
Subunit
Homodimer. Interacts with PKM.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 453-759 | Damage-control phosphatase ARMT1-like metal-binding | ||||
Sequence: EEALDGVVNRAIASQPDAIDAAERAEKFRQKYWNKLQTLRHQPFAYGTLTVRSLLETREHCLNEFNFPDPYSKVKQRENGIALKCFQRVIRSLDSLGWEERQFALVKGLLAGNVFDWGAKAVSDVLESEPQFGFEEAKRKLQERPWLVDSYGEWLQRLKGPPHKCALIFADNSGIDIILGVFPFVRELLFRGTEVILACNSGPALNDVTYNESLIVAERIAAMDPLIQSALREDKLLLVQTGSSSPCLDLSRLDKGLAVLVRERSTDLVVIEGMGRAIHTNYHAALRCESLKLAVIKNSWLADRLGG |
Sequence similarities
Belongs to the type II pantothenate kinase family.
In the N-terminal section; belongs to the type II pantothenate kinase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length773
- Mass (Da)86,598
- Last updated2013-01-09 v2
- Checksum4E1FDF9FEDD79485
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A5F8GSP9 | A0A5F8GSP9_MONDO | PANK4 | 786 |
Keywords
- Technical term