F7CTF8 · F7CTF8_MOUSE
- ProteinMitochondrial fission factor
- GeneMff
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids220 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Publications for F7CTF8
Mitochondrial fission factor (Mff) is required for organization of the mitochondrial sheath in spermatids.
- CategoriesFunction, Phenotypes & Variants, Subcellular Location
- SourceMGI: 1922984
MAVS is energized by Mff which senses mitochondrial metabolism via AMPK for acute antiviral immunity.
- CategoriesFunction, Subcellular Location
- SourceMGI: 1922984
ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects.
- CategoriesFunction, Interaction
- SourceMGI: 1922984
Removal of the Mitochondrial Fission Factor Mff Exacerbates Neuronal Loss and Neurological Phenotypes in a Huntington's Disease Mouse Model.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 1922984
A Genetic Interaction Map of Insulin Production Identifies Mfi as an Inhibitor of Mitochondrial Fission.
- CategoryInteraction
- SourceMGI: 1922984
Elimination of paternal mitochondria in mouse embryos occurs through autophagic degradation dependent on PARKIN and MUL1.
- CategorySubcellular Location
- SourceMGI: 1922984
Cooperative and independent roles of the Drp1 adaptors Mff, MiD49 and MiD51 in mitochondrial fission.
- CategoriesFunction, Interaction
- SourceMGI: 1922984
Titration of mitochondrial fusion rescues Mff-deficient cardiomyopathy.
- CategoryFunction
- SourceMGI: 1922984
Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells.
- CategorySubcellular Location
- SourceMGI: 1922984
Peroxisomes are signaling platforms for antiviral innate immunity.
- CategoryFunction
- SourceMGI: 1922984