F7CIP8 · F7CIP8_MOUSE
- ProteinPrenylcysteine oxidase 1
- GenePcyox1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids197 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
function
Prenylcysteine oxidase that cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine. Only active against free prenylcysteines and not prenylcysteine residues within prenylated proteins or peptides. Involved in the final step in the degradation of prenylated proteins, by degrading prenylcysteines after the protein has been degraded.
Catalytic activity
- S-(2E,6E)-farnesyl-L-cysteine + O2 + H2O = (2E,6E)-farnesal + L-cysteine + H2O2This reaction proceeds in the forward direction.
Cofactor
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | lysosome | |
Molecular Function | prenylcysteine oxidase activity | |
Biological Process | prenylcysteine catabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePrenylcysteine oxidase 1
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionF7CIP8
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Structure
Sequence
- Sequence statusFragment
- Length197
- Mass (Da)22,305
- Last updated2011-07-27 v1
- MD5 Checksum4F32B5B69E013E607F423BFDF540A462
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q9CQF9 | PCYOX_MOUSE | Pcyox1 | 505 | ||
A0A0N4SWD3 | A0A0N4SWD3_MOUSE | Pcyox1 | 148 | ||
D3Z275 | D3Z275_MOUSE | Pcyox1 | 214 |
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Non-terminal residue | 197 | ||||
Keywords
- Technical term