F7CBU9 · F7CBU9_MONDO

Function

Catalytic activity

  • 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H+
    This reaction proceeds in the forward direction.
  • 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 2-O-hexadecyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H+
    This reaction proceeds in the forward direction.
  • 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + hexadecanoate + H+
    This reaction proceeds in the forward direction.
  • 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + hexadecanoate + H+
    This reaction proceeds in the forward direction.
  • 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O = 1-octadecanoyl-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H+
    This reaction proceeds in the forward direction.
  • 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H+
    This reaction proceeds in the forward direction.
  • 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine
    This reaction proceeds in the forward direction.
  • 1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z,15Z)-octadecatrienoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H+
    This reaction proceeds in the forward direction.
  • 1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine
    This reaction proceeds in the forward direction.
  • 2-(prostaglandin E2)-sn-glycero-3-phosphocholine + H2O = prostaglandin E2 + sn-glycerol 3-phosphocholine + H+
    This reaction proceeds in the forward direction.
  • 2-(prostaglandin E2)-sn-glycero-3-phosphoethanolamine + H2O = sn-glycero-3-phosphoethanolamine + prostaglandin E2 + H+
    This reaction proceeds in the forward direction.
  • 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H+
    This reaction proceeds in the forward direction.
  • 2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H+
    This reaction proceeds in the forward direction.
  • 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H+
    This reaction proceeds in the forward direction.
  • a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H+
    This reaction proceeds in the forward direction.
    EC:3.1.1.4 (UniProtKB | ENZYME | Rhea)
  • a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H+
    This reaction proceeds in the forward direction.
    EC:3.1.1.5 (UniProtKB | ENZYME | Rhea)

Pathway

Lipid metabolism; arachidonate metabolism.
Lipid metabolism; leukotriene B4 biosynthesis.
Lipid metabolism; prostaglandin biosynthesis.
Membrane lipid metabolism; glycerophospholipid metabolism.

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentendoplasmic reticulum
Cellular ComponentGolgi apparatus
Cellular ComponentGolgi membrane
Cellular Componentnuclear envelope
Cellular Componentnucleus
Molecular Functioncalcium ion binding
Molecular Functioncalcium-dependent phospholipase A2 activity
Molecular Functioncalcium-dependent phospholipid binding
Molecular Functioncalcium-independent phospholipase A2 activity
Molecular Functionceramide 1-phosphate binding
Molecular Functionlysophospholipase activity
Molecular FunctionO-acyltransferase activity
Molecular Functionphosphatidylinositol-3-phosphate binding
Molecular Functionphosphatidylinositol-4-phosphate binding
Molecular Functionphosphatidylinositol-5-phosphate binding
Biological Processarachidonic acid metabolic process
Biological Processarachidonic acid secretion
Biological Processcellular response to antibiotic
Biological Processestablishment of localization in cell
Biological Processglycerol metabolic process
Biological Processglycerophospholipid catabolic process
Biological Processleukotriene biosynthetic process
Biological Processmonoacylglycerol biosynthetic process
Biological Processphosphatidylcholine acyl-chain remodeling
Biological Processphosphatidylcholine catabolic process
Biological Processphosphatidylglycerol catabolic process
Biological Processplatelet activating factor biosynthetic process
Biological Processpositive regulation of macrophage activation
Biological Processpositive regulation of platelet activation
Biological Processpositive regulation of prostaglandin secretion
Biological Processpositive regulation of T-helper 1 type immune response
Biological Processprostaglandin biosynthetic process
Biological Processregulation of cell population proliferation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phospholipase A2
  • EC number

Gene names

    • Name
      PLA2G4A

Organism names

Accessions

  • Primary accession
    F7CBU9

Proteomes

Subcellular Location

Keywords

Expression

Gene expression databases

Interaction

Subunit

Interacts with KAT5.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain6-122C2
Domain134-704PLA2c

Domain

The N-terminal C2 domain associates with lipid membranes upon calcium binding.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    713
  • Mass (Da)
    81,110
  • Last updated
    2019-12-11 v2
  • Checksum
    9B18BCED645BB218
MSCIDPYQHIIVEHQYSHKFTVNVLRATKVTKGAFGDMLDTPDPYVELFISSTPDSRKRTRHFNNDVNPVWNETFEFILDPNQENILEITLMDANYVMDETLGTATFPISSMKVGEKKEVPFIFNEVFMSLSVLHTSSSPDLRFSMALCDQEKIFRQQRKENIKESMKKLLGPKKSEGLCSARDVPVIAVLGSGGGFRAMVGFSGVMKALYESGILDCATYVAGLSGSTWYMSSLYSHPDFPEKGPKEINEELMASVSHNPLLLLTPQKVKRYIESLWKKKSSGQPVTFTDIFGMLIGETLINNRMSSTLSSLKEKVNEAQCPLPLFTCLHVKPDVSELMFADWVEFSPYEIGMAKYGTFMAPDLFGSKFFMGTVVKKYEENPLHFLMGVWGSAFSILFNRGSTMEEELGTENADAEKEYQNNNQASWVQRMLMALVSDSTLFNTREGRAGKVHNFMLGLNLNTSYPLSPLRGISTQDSMEEDELDAAVADPDEFERIYEPLDVKSKKIHVVDSGLTFNLPYPLILRPQRGVDLIISFDFSARPSDSSPPFKEILLAEKWAKMNKLPFPKIDPYVFDREGLKECYVFKPKNPDVEKDCPTIIHFVLANINFRDYKAPGIPRETQEEKDFADFDIFDDPESPFSTFNFQYPNQAFKRLHDLMHFNTMNNIDVIKNAIFESIEYRRQNPSRCSVSLSNIEARRFFNKDSLSKPSA

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A5F8H4A0A0A5F8H4A0_MONDOPLA2G4A712

Keywords

Genome annotation databases

Similar Proteins

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