F7BTP0 · F7BTP0_MOUSE
- ProteinNon-homologous end-joining factor 1
- GeneNhej1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids165 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Publications for F7BTP0
An XRCC4 mutant mouse, a model for human X4 syndrome, reveals interplays with Xlf, PAXX, and ATM in lymphoid development.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 1922820
Leaky severe combined immunodeficiency in mice lacking non-homologous end joining factors XLF and MRI.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 1922820
ERCC6L2 promotes DNA orientation-specific recombination in mammalian cells.
- CategoriesFunction
- SourceMGI: 1922820
XLF and H2AX function in series to promote replication fork stability.
- CategoriesFunction, Interaction
- SourceMGI: 1922820
SOX17 regulates uterine epithelial-stromal cross-talk acting via a distal enhancer upstream of Ihh.
- CategoriesFunction
- SourceMGI: 1922820
MRI is a DNA damage response adaptor during classical non-homologous end joining.
- CategoriesFunction, Interaction
- SourceMGI: 1922820
C-NHEJ without indels is robust and requires synergistic function of distinct XLF domains.
- CategoriesFunction
- SourceMGI: 1922820
PAXX and Xlf interplay revealed by impaired CNS development and immunodeficiency of double KO mice.
- CategoriesFunction, Interaction
- SourceMGI: 1922820
Composition and dosage of a multipartite enhancer cluster control developmental expression of Ihh (Indian hedgehog).
- CategoriesFunction, Sequences
- SourceMGI: 1922820
Contribution of canonical nonhomologous end joining to chromosomal rearrangements is enhanced by ATM kinase deficiency.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 1922820
PAXX promotes KU accumulation at DNA breaks and is essential for end- joining in XLF-deficient mice.
- CategoriesFunction
- SourceMGI: 1922820
Synthetic lethality between PAXX and XLF in mammalian development.
- CategoriesFunction
- SourceMGI: 1922820
RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair.
- CategoriesFunction
- SourceMGI: 1922820
Akt-mediated phosphorylation of XLF impairs non-homologous end-joining DNA repair.
- CategoriesFunction
- SourceMGI: 1922820
Hematopoietic stem cell dysfunction underlies the progressive lymphocytopenia in XLF/Cernunnos deficiency.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 1922820
Opposing roles for 53BP1 during homologous recombination.
- CategoriesFunction
- SourceMGI: 1922820