F7BIK9 · F7BIK9_XENTR

Function

function

Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular ComponentRISC complex
Cellular ComponentRISC-loading complex
Molecular Functiondouble-stranded RNA binding
Molecular FunctionmiRNA binding
Molecular Functionpre-miRNA binding
Molecular Functionprotein homodimerization activity
Molecular FunctionsiRNA binding
Biological Processglobal gene silencing by mRNA cleavage
Biological Processpre-miRNA processing
Biological Processregulation of miRNA processing
Biological Processregulation of siRNA processing
Biological Processregulation of translation
Biological Processregulation of viral transcription
Biological ProcessRISC complex assembly
Biological ProcesssiRNA processing

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    RISC-loading complex subunit TARBP2

Gene names

    • Name
      tarbp2
    • Synonyms
      TARBP2

Organism names

Accessions

  • Primary accession
    F7BIK9

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-22
ChainPRO_503016986723-379RISC-loading complex subunit TARBP2

Expression

Gene expression databases

Interaction

Subunit

Self-associates. Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as RISC.

Family & Domains

Features

Showing features for domain, compositional bias, region.

Type
IDPosition(s)Description
Domain47-124DRBM
Domain178-246DRBM
Compositional bias250-268Basic and acidic residues
Region250-271Disordered
Domain306-374DRBM

Sequence similarities

Belongs to the TARBP2 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    379
  • Mass (Da)
    41,184
  • Last updated
    2021-06-02 v4
  • Checksum
    3DD8E436599928F4
MKKRHLGSVVLLVIVRFEDGGAETTGPDIHVPMTGIEQMLASSPGKTPISLLQEYGTRVGKTPVYDLLKAEGQAHQPNFTFRVSVGDINCTGQCSAPPSTRGQGPSKKAAKHKAAEVALSLLKGGDMFGMMCEENSVMLSVEQPVELREVADVSPPPTNRNHTIEMKPPLSAQQSECNPVGALQELVVQKGWRLPEYTVTQESGPAHRKEFTMTCRVERFLEIGSGTSKKLAKRNAAAKMLLQIHRVPAEHRESGETEPEEDQFSMGKLDGSRGRGTACTWDSLRNSSGEKILHLRSNPLTILSSGFCSLLQDLSEEQSFQISYLDIDEPSLSGLYQCLVELSTQPTTVCHGSATTRDAARANAAHNALQYLKIMAGGK

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias250-268Basic and acidic residues

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help