F7AEE9 · F7AEE9_MONDO
- ProteinVitamin K-dependent protein C
- GenePROC
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids460 (go to sequence)
- Protein existencePredicted
- Annotation score4/5
Function
function
Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function.
Catalytic activity
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 255 | Charge relay system | |||
Active site | 301 | Charge relay system | |||
Active site | 400 | Charge relay system | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum | |
Cellular Component | extracellular space | |
Cellular Component | Golgi apparatus | |
Cellular Component | membrane | |
Molecular Function | calcium ion binding | |
Molecular Function | serine-type endopeptidase activity | |
Biological Process | blood coagulation | |
Biological Process | negative regulation of apoptotic process | |
Biological Process | negative regulation of blood coagulation | |
Biological Process | negative regulation of inflammatory response | |
Biological Process | positive regulation of establishment of endothelial barrier | |
Biological Process | proteolysis |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameVitamin K-dependent protein C
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Metatheria > Didelphimorphia > Didelphidae > Monodelphis
Accessions
- Primary accessionF7AEE9
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 12-36 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Disulfide bond | 111↔121 | ||||
Disulfide bond | 132↔141 | ||||
Keywords
- PTM
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 61-107 | Gla | |||
Domain | 107-142 | EGF-like | |||
Domain | 214-448 | Peptidase S1 | |||
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length460
- Mass (Da)52,021
- Last updated2013-01-09 v2
- ChecksumAC778E068B37748E
Keywords
- Technical term