F7AEE9 · F7AEE9_MONDO

Function

function

Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

  • Degradation of blood coagulation factors Va and VIIIa.
    EC:3.4.21.69 (UniProtKB | ENZYME | Rhea)

Features

Showing features for active site.

146050100150200250300350400450
TypeIDPosition(s)Description
Active site255Charge relay system
Active site301Charge relay system
Active site400Charge relay system

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum
Cellular Componentextracellular space
Cellular ComponentGolgi apparatus
Cellular Componentmembrane
Molecular Functioncalcium ion binding
Molecular Functionserine-type endopeptidase activity
Biological Processblood coagulation
Biological Processnegative regulation of apoptotic process
Biological Processnegative regulation of blood coagulation
Biological Processnegative regulation of inflammatory response
Biological Processpositive regulation of establishment of endothelial barrier
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Vitamin K-dependent protein C
  • EC number
  • Alternative names
    • Anticoagulant protein C
    • Autoprothrombin IIA
    • Blood coagulation factor XIV

Gene names

    • Name
      PROC

Organism names

Accessions

  • Primary accession
    F7AEE9

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane12-36Helical

Keywords

PTM/Processing

Features

Showing features for disulfide bond.

TypeIDPosition(s)Description
Disulfide bond111↔121
Disulfide bond132↔141

Keywords

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain61-107Gla
Domain107-142EGF-like
Domain214-448Peptidase S1

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    460
  • Mass (Da)
    52,021
  • Last updated
    2013-01-09 v2
  • Checksum
    AC778E068B37748E
MATRRQHCQSSTAHICVSFSKMWQFVSFLVFVASWYSPGGHGMSVFSSSKDANQILRIQKRANSFLEEIKPGNLERECYEEICELEEVTEIFVTREETLAFWSKYMDGDLCDPQPCPNGTCIDGIGSFQCICKEGWEGRLCGHEVSYTNCSINNGGCAHYCTEDLQNQQRHCSCALGYQESDNPMECDPIANFPCGKPKVNYPIIDFDQLQIRILGGKSTNKGDSPWQVILLDLEGKLKCGGVLIHSSWVLTAAHCVENPKKLTVRLGEHDLRRYDNSEMDFHIREAIVHPNYTKSTSDNDIALLYLDKPTIFSKNILPICLPNLGLAHRELMKVGREMVITGWGRQREESRNRTYVLRFTKIPLASHDECSQTMHNRVSENMLCAGILRDKRDACEGDSGGPMVTEFRGTWFLVGLVSWGEGCGRPDTFGIYTKVSQYLNWIRDHIKAKEAILKNDSAP

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

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