F6ZPP5 · F6ZPP5_MONDO
- ProteinAprataxin
- GeneAPTX
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids368 (go to sequence)
- Protein existencePredicted
- Annotation score4/5
Function
Catalytic activity
- a 3'-end 2'-deoxyribonucleotide-3'-diphospho-5'-guanosine-DNA + H2O = a 3'-end 2'-deoxyribonucleotide 3'-phosphate-DNA + GMP + 2 H+
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | chromatin | |
Cellular Component | nucleolus | |
Cellular Component | nucleoplasm | |
Cellular Component | nucleus | |
Molecular Function | chromatin binding | |
Molecular Function | DNA 5'-adenosine monophosphate hydrolase activity | |
Molecular Function | DNA-3'-diphospho-5'-guanosine diphosphatase | |
Molecular Function | double-stranded RNA binding | |
Molecular Function | metal ion binding | |
Molecular Function | mismatched DNA binding | |
Molecular Function | phosphoglycolate phosphatase activity | |
Molecular Function | phosphoprotein binding | |
Molecular Function | single-strand break-containing DNA binding | |
Molecular Function | single-stranded DNA binding | |
Biological Process | regulation of protein stability | |
Biological Process | single strand break repair |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAprataxin
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Metatheria > Didelphimorphia > Didelphidae > Monodelphis
Accessions
- Primary accessionF6ZPP5
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-16 | |||||
Sequence: MQLVFIFFCSFSACYL | ||||||
Chain | PRO_5023924229 | 17-368 | Aprataxin | |||
Sequence: RSMTQVCWLVKQDNCHQRIRLPHLETVVIGRGPETKITDKKCSRQQVHLKAECNKGYVKVKQMGINPTSVDSVIIGKDQEVMLKPGQILHIVNELYPYTVQFVEETEKPVSGGERKRKRPCDDNETDEEIKSGKVEAEPLDCSEGTSALKPPTSTRSVPDLLKGEKPSHKKASFGHWSQGLTISMYDRRMQVYRDDRVVVINDKFPKAQYHWLVLPWDSISSLKNLNQKHVKLLRHMQTVGGKMIDRCVESKRVRFRLGYHAVPSMNHLHLHVISQDFDSPCLRNKKHWNSFNTEYFLESEDVINMIKKHGKVIIPQGVSDFLNLPLCCHICKEQQPTIPQLKDHLRKHGSK |
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain, motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 123-187 | Disordered | ||||
Sequence: EKPVSGGERKRKRPCDDNETDEEIKSGKVEAEPLDCSEGTSALKPPTSTRSVPDLLKGEKPSHKK | ||||||
Compositional bias | 124-154 | Basic and acidic residues | ||||
Sequence: KPVSGGERKRKRPCDDNETDEEIKSGKVEAE | ||||||
Domain | 194-299 | HIT | ||||
Sequence: SQGLTISMYDRRMQVYRDDRVVVINDKFPKAQYHWLVLPWDSISSLKNLNQKHVKLLRHMQTVGGKMIDRCVESKRVRFRLGYHAVPSMNHLHLHVISQDFDSPCL | ||||||
Motif | 284-288 | Histidine triad motif | ||||
Sequence: HLHLH |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length368
- Mass (Da)42,452
- Last updated2019-12-11 v3
- Checksum7B1EB4C4E10CA09F
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 124-154 | Basic and acidic residues | ||||
Sequence: KPVSGGERKRKRPCDDNETDEEIKSGKVEAE |
Keywords
- Technical term