F6YVB9 · E2F7_XENTR

Function

function

Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as e2f1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator (By similarity).

Features

Showing features for dna binding.

1862100200300400500600700800
TypeIDPosition(s)Description
DNA binding140-209
DNA binding279-364

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Cellular Componenttranscription regulator complex
Molecular FunctionDNA-binding transcription factor activity
Molecular FunctionDNA-binding transcription repressor activity
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological Processchorionic trophoblast cell differentiation
Biological ProcessDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
Biological Processhepatocyte differentiation
Biological Processnegative regulation of cytokinesis
Biological Processnegative regulation of G1/S transition of mitotic cell cycle
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processpositive regulation of DNA endoreduplication
Biological Processsprouting angiogenesis

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Transcription factor E2F7
  • Short names
    E2F-7

Gene names

    • Name
      e2f7

Organism names

Accessions

  • Primary accession
    F6YVB9

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004207071-862Transcription factor E2F7

Proteomic databases

Interaction

Subunit

Homodimer and heterodimer: mainly forms homodimers and, to a lesser extent, heterodimers with e2f8.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region561-592Disordered
Compositional bias574-592Basic and acidic residues
Region617-643Disordered
Compositional bias788-814Polar residues
Region788-862Disordered
Compositional bias829-862Polar residues

Domain

In contrast to classical members of the E2F transcription factor, atypical members contain 2 DNA-binding domains and regulate transcription in a DP-independent manner. Both DNA-binding domains are required for DNA-binding and are proposed to form an intramolecular structure that is similar to the winged helix structure of the E2F-DP heterodimer (By similarity).

Sequence similarities

Belongs to the E2F/DP family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    862
  • Mass (Da)
    95,487
  • Last updated
    2011-07-27 v1
  • Checksum
    00A75B31066023E2
MEVTSCLTLKDLISTKKNKSDPVADGRSAQKENMFDRFKISPRLPLRSEPIDLSKQKSFTPERIPVTPVKVAERPQADPWTPTANLKMLISAASPEIRDREKKKELFRPIENNGIEETDTDLQLMDSVDDIDDLEKRPSRKQKSLGLLCQKFLARYPSYPISTEKMTISLDEAASSLGVERRRIYDIVNVLESLHLVSRVAKNQYCWHGQHNLNETLRNLQHIGEKQNYRAQIACFNLRDMGMEYKCDEQEKGCHIDHLNTPLIELSEADCPSVSSSSRKDKSLRIMSQKFVMLFLVSTTKIITLEIAAKILIEESQDAADHSKFKTKVRRLYDIANVLTSLGLIKKVHVTDERGRKPAFKWIGPVDFTAEDQKMEVTTTIPSPDSKKDACNLSPASDRVKQRLFRHSSFNIVQSFSAVKRKVCSHPCSPQKPQGVESSDSYASKMAHLATICKPKAEEDSKNGNIENSSLPFSVVVPMPVDSDYRVKPVVHQVPLVSHKTVCEPLGIMPPSQSNEDCTNHGFVPNQPYMYLPSNSVFMLCGNLSEGKATDHLAMSLYPVPGSDSPTLEETTMSKQERPTKRQLNDKDDAPLSLVLPKKSRVDNTQSLQKPICKTTTPEQLQHVSREEEYNTEPVTKHSNVGETTEEVGSRILPHENVHLHPAVPPQFLYVPTTQGLNSFNFLLPANHSAGLSQSQLASLNVPYVMVPSSALTAFPFICSPAVSSGASGSTLNGRMNFSQAGTSSPTRLIIGAPQMAVPQPPEPAVDQTKNLSPLSVSPVSAKCASSKADSHDSLSQSIHTAKLHKSPTPSTPKSIRPLHKDAFFKTPGSLDVSSSRKPQRTQTRTSSSAQRKLDIDSSAGN

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8J0QXT9A0A8J0QXT9_XENTRe2f7858

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias574-592Basic and acidic residues
Compositional bias788-814Polar residues
Compositional bias829-862Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAMC01048174
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AAMC01048175
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AAMC01048176
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

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Disclaimer

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