F6YVB9 · E2F7_XENTR
- ProteinTranscription factor E2F7
- Genee2f7
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids862 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as e2f1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator (By similarity).
Features
Showing features for dna binding.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
DNA binding | 140-209 | |||||
Sequence: RKQKSLGLLCQKFLARYPSYPISTEKMTISLDEAASSLGVERRRIYDIVNVLESLHLVSRVAKNQYCWHG | ||||||
DNA binding | 279-364 | |||||
Sequence: RKDKSLRIMSQKFVMLFLVSTTKIITLEIAAKILIEESQDAADHSKFKTKVRRLYDIANVLTSLGLIKKVHVTDERGRKPAFKWIG |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Cellular Component | transcription regulator complex | |
Molecular Function | DNA-binding transcription factor activity | |
Molecular Function | DNA-binding transcription repressor activity | |
Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
Biological Process | chorionic trophoblast cell differentiation | |
Biological Process | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | |
Biological Process | hepatocyte differentiation | |
Biological Process | negative regulation of cytokinesis | |
Biological Process | negative regulation of G1/S transition of mitotic cell cycle | |
Biological Process | negative regulation of transcription by RNA polymerase II | |
Biological Process | positive regulation of DNA endoreduplication | |
Biological Process | sprouting angiogenesis |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameTranscription factor E2F7
- Short namesE2F-7
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Pipoidea > Pipidae > Xenopodinae > Xenopus > Silurana
Accessions
- Primary accessionF6YVB9
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000420707 | 1-862 | Transcription factor E2F7 | |||
Sequence: MEVTSCLTLKDLISTKKNKSDPVADGRSAQKENMFDRFKISPRLPLRSEPIDLSKQKSFTPERIPVTPVKVAERPQADPWTPTANLKMLISAASPEIRDREKKKELFRPIENNGIEETDTDLQLMDSVDDIDDLEKRPSRKQKSLGLLCQKFLARYPSYPISTEKMTISLDEAASSLGVERRRIYDIVNVLESLHLVSRVAKNQYCWHGQHNLNETLRNLQHIGEKQNYRAQIACFNLRDMGMEYKCDEQEKGCHIDHLNTPLIELSEADCPSVSSSSRKDKSLRIMSQKFVMLFLVSTTKIITLEIAAKILIEESQDAADHSKFKTKVRRLYDIANVLTSLGLIKKVHVTDERGRKPAFKWIGPVDFTAEDQKMEVTTTIPSPDSKKDACNLSPASDRVKQRLFRHSSFNIVQSFSAVKRKVCSHPCSPQKPQGVESSDSYASKMAHLATICKPKAEEDSKNGNIENSSLPFSVVVPMPVDSDYRVKPVVHQVPLVSHKTVCEPLGIMPPSQSNEDCTNHGFVPNQPYMYLPSNSVFMLCGNLSEGKATDHLAMSLYPVPGSDSPTLEETTMSKQERPTKRQLNDKDDAPLSLVLPKKSRVDNTQSLQKPICKTTTPEQLQHVSREEEYNTEPVTKHSNVGETTEEVGSRILPHENVHLHPAVPPQFLYVPTTQGLNSFNFLLPANHSAGLSQSQLASLNVPYVMVPSSALTAFPFICSPAVSSGASGSTLNGRMNFSQAGTSSPTRLIIGAPQMAVPQPPEPAVDQTKNLSPLSVSPVSAKCASSKADSHDSLSQSIHTAKLHKSPTPSTPKSIRPLHKDAFFKTPGSLDVSSSRKPQRTQTRTSSSAQRKLDIDSSAGN |
Proteomic databases
Interaction
Subunit
Homodimer and heterodimer: mainly forms homodimers and, to a lesser extent, heterodimers with e2f8.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 561-592 | Disordered | ||||
Sequence: PGSDSPTLEETTMSKQERPTKRQLNDKDDAPL | ||||||
Compositional bias | 574-592 | Basic and acidic residues | ||||
Sequence: SKQERPTKRQLNDKDDAPL | ||||||
Region | 617-643 | Disordered | ||||
Sequence: TPEQLQHVSREEEYNTEPVTKHSNVGE | ||||||
Compositional bias | 788-814 | Polar residues | ||||
Sequence: KADSHDSLSQSIHTAKLHKSPTPSTPK | ||||||
Region | 788-862 | Disordered | ||||
Sequence: KADSHDSLSQSIHTAKLHKSPTPSTPKSIRPLHKDAFFKTPGSLDVSSSRKPQRTQTRTSSSAQRKLDIDSSAGN | ||||||
Compositional bias | 829-862 | Polar residues | ||||
Sequence: GSLDVSSSRKPQRTQTRTSSSAQRKLDIDSSAGN |
Domain
In contrast to classical members of the E2F transcription factor, atypical members contain 2 DNA-binding domains and regulate transcription in a DP-independent manner. Both DNA-binding domains are required for DNA-binding and are proposed to form an intramolecular structure that is similar to the winged helix structure of the E2F-DP heterodimer (By similarity).
Sequence similarities
Belongs to the E2F/DP family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length862
- Mass (Da)95,487
- Last updated2011-07-27 v1
- Checksum00A75B31066023E2
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8J0QXT9 | A0A8J0QXT9_XENTR | e2f7 | 858 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 574-592 | Basic and acidic residues | ||||
Sequence: SKQERPTKRQLNDKDDAPL | ||||||
Compositional bias | 788-814 | Polar residues | ||||
Sequence: KADSHDSLSQSIHTAKLHKSPTPSTPK | ||||||
Compositional bias | 829-862 | Polar residues | ||||
Sequence: GSLDVSSSRKPQRTQTRTSSSAQRKLDIDSSAGN |
Keywords
- Technical term