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F6YK65 · F6YK65_MACMU

Function

function

Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

  • Selective cleavage of Arg-|-Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg-|-Xaa bond in complement component C5 alpha-chain to form C5a and C5b.
    EC:3.4.21.43 (UniProtKB | ENZYME | Rhea)

Features

Showing features for active site.

1752100200300400500600700
TypeIDPosition(s)Description
Active site507Charge relay system
Active site561Charge relay system
Active site679Charge relay system

GO annotations

AspectTerm
Cellular Componentextracellular region
Molecular Functionserine-type endopeptidase activity
Biological Processcomplement activation, classical pathway
Biological Processinnate immune response
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Complement C2
  • EC number
  • Alternative names
    • C3/C5 convertase

Gene names

    • Name
      CFB

Organism names

  • Taxonomic identifier
  • Strain
    • 17573
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Cercopithecinae > Macaca

Accessions

  • Primary accession
    F6YK65
  • Secondary accessions
    • A0A663DFU2
    • G7MRL3

Proteomes

Organism-specific databases

Subcellular Location

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for disulfide bond.

TypeIDPosition(s)Description
Disulfide bond117↔144
Disulfide bond177↔204

Keywords

Proteomic databases

Expression

Gene expression databases

Structure

Family & Domains

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    752
  • Mass (Da)
    83,317
  • Last updated
    2016-11-30 v2
  • MD5 Checksum
    78F71CA275EB08594A2C25F8D11BF46B
MDPLMVLFCLLFLYPGPADSATSCPQNVNISGGTFTLSHGWAPGSLLIYSCPQGLYPSPASRLCKSSGQWQTPRATRSLTKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGSRFGHGDKVRYRCSSNLVLTGSAERECQGNGVWSGTEPICRQPYSYDFPEDVAPALGTSFSHMLGATNPTQRTKESLGRKIQIQRSGHLNLYLLLDSSQSVSENDFLIFKESASLMVDRIFSFEINVSVAIITFASEPKVLMSVLNVNSRDITEVISSLENAKYKDHENGTGTNTYAALNSVYLMMNNQMQLLGMKTMAWQEIRHAIILLTDGKSNMGGSPKTAVDQIREILNINQKRNDYLDIYAIGVGKLDVDWRELNELGSKKDGERHAFILQDTKALHQVFEHMLDVSKLTDTICGVGNMSANASDQERTPWHVTIKPKSQETCRGALISDQWVLTAAHCFRDGNDHSLWRVNVGDPKSQWGKEFLIEKAVISPGFDVFAKKNQGILEFYGDDIALLKLAQKVKMSTHARPICLPCTMEANLALRRPQGSTCRDHENELLNKQSVPAHFVALNGSKLNINLKMGVEWTSCAEVVSQEKTMFPNLTDVREVVTDQFLCSGTQEDESPCKGESGGAVFLERRFRFFQVGLVSWGLYNPCLGSADKNSRKRAPRSKVPPPRDFHINLFRMQPWLRQHLGDVLNFLPL

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
F6YJY7F6YJY7_MACMUCFB763
F6YJW2F6YJW2_MACMUCFB1265

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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