F6Y6W8 · F6Y6W8_MONDO

Function

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentearly endosome
Cellular Componentendosome membrane
Cellular Componentexternal side of plasma membrane
Cellular Componentlipopolysaccharide receptor complex
Cellular Componentperinuclear region of cytoplasm
Cellular Componentphagocytic cup
Cellular Componentplasma membrane
Cellular Componentruffle
Molecular Functionidentical protein binding
Molecular Functionlipopolysaccharide binding
Molecular Functionlipopolysaccharide immune receptor activity
Molecular Functionprotein heterodimerization activity
Molecular Functionsignaling receptor binding
Molecular Functiontransmembrane signaling receptor activity
Biological Processastrocyte development
Biological ProcessB cell proliferation involved in immune response
Biological Processcellular response to amyloid-beta
Biological Processcellular response to lipoteichoic acid
Biological Processcellular response to mechanical stimulus
Biological Processcellular response to oxidised low-density lipoprotein particle stimulus
Biological Processcellular response to platelet-derived growth factor stimulus
Biological Processcellular response to type II interferon
Biological Processdefense response to Gram-negative bacterium
Biological Processdetection of lipopolysaccharide
Biological ProcessERK1 and ERK2 cascade
Biological Processgene expression
Biological Processinflammatory response
Biological Processintestinal epithelial structure maintenance
Biological ProcessJNK cascade
Biological Processmacrophage activation
Biological ProcessMHC class II biosynthetic process
Biological Processmicroglia differentiation
Biological ProcessMyD88-dependent toll-like receptor signaling pathway
Biological Processnegative regulation of cold-induced thermogenesis
Biological Processnegative regulation of ERK1 and ERK2 cascade
Biological Processnegative regulation of interleukin-17 production
Biological Processnegative regulation of interleukin-23 production
Biological Processnegative regulation of interleukin-6 production
Biological Processnegative regulation of tumor necrosis factor production
Biological Processnegative regulation of type II interferon production
Biological Processnitric oxide biosynthetic process
Biological Processnitric oxide production involved in inflammatory response
Biological Processnucleotide-binding oligomerization domain containing 1 signaling pathway
Biological Processnucleotide-binding oligomerization domain containing 2 signaling pathway
Biological Processphagocytosis
Biological Processpositive regulation of B cell proliferation
Biological Processpositive regulation of canonical NF-kappaB signal transduction
Biological Processpositive regulation of cellular response to macrophage colony-stimulating factor stimulus
Biological Processpositive regulation of chemokine (C-X-C motif) ligand 2 production
Biological Processpositive regulation of cytokine production involved in inflammatory response
Biological Processpositive regulation of ERK1 and ERK2 cascade
Biological Processpositive regulation of extrinsic apoptotic signaling pathway
Biological Processpositive regulation of inflammatory response
Biological Processpositive regulation of interferon-alpha production
Biological Processpositive regulation of interferon-beta production
Biological Processpositive regulation of interleukin-1 beta production
Biological Processpositive regulation of interleukin-10 production
Biological Processpositive regulation of interleukin-12 production
Biological Processpositive regulation of interleukin-6 production
Biological Processpositive regulation of interleukin-8 production
Biological Processpositive regulation of JNK cascade
Biological Processpositive regulation of macrophage activation
Biological Processpositive regulation of macrophage cytokine production
Biological Processpositive regulation of matrix metallopeptidase secretion
Biological Processpositive regulation of MHC class II biosynthetic process
Biological Processpositive regulation of nitric oxide biosynthetic process
Biological Processpositive regulation of nitric-oxide synthase biosynthetic process
Biological Processpositive regulation of NLRP3 inflammasome complex assembly
Biological Processpositive regulation of non-canonical NF-kappaB signal transduction
Biological Processpositive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
Biological Processpositive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
Biological Processpositive regulation of platelet activation
Biological Processpositive regulation of reactive oxygen species biosynthetic process
Biological Processpositive regulation of smooth muscle cell migration
Biological Processpositive regulation of smooth muscle cell proliferation
Biological Processpositive regulation of stress-activated MAPK cascade
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processpositive regulation of tumor necrosis factor production
Biological Processpositive regulation of type II interferon production
Biological Processregulation of dendritic cell cytokine production
Biological Processstress-activated MAPK cascade
Biological Processtoll-like receptor 4 signaling pathway
Biological ProcessTRIF-dependent toll-like receptor signaling pathway
Biological Processwound healing involved in inflammatory response

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Toll-like receptor 4

Gene names

    • Name
      TLR4

Organism names

Accessions

  • Primary accession
    F6Y6W8

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane633-655Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-24
ChainPRO_501111811925-838Toll-like receptor 4

Keywords

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain672-815TIR

Sequence similarities

Belongs to the Toll-like receptor family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    838
  • Mass (Da)
    95,177
  • Last updated
    2011-07-27 v1
  • Checksum
    02481C5B7EFA73BA
MVPWMVMALIMATTFFSCPDPGSCHSCLEVFPSIEYQCMDQNFSKVPMDIPASTQKLDLSFNPLRSLAPRSFSRITELRILDLSRCDIQKIEDDTYEGLHNLSTLILTGNPIQSLGIRAFYGLPKLQKLVVVETNLMSLEDFPIGHIITLQELHLGHNSISSLQLPSYFASFSSMKHLDLHLNQIKNISDGDLEPVKLNPNLTLDLSENPIQYIHPGAFKGIHLSGLKLRSSFHNSTIMEACIKGMTGLKVGKLVLGNYKNDIQMTSFESSILDGLCEVDIGEFRMVQPSQFPSDGNGVFKCLVNVSVLFLVNTDIDQLTNLPIFPKLFSLSLTDCNFDIMPDLPSISLPSLKELKVTHHKDLTTLSDLALPNLQILDLSKNSLNVLSCCSDKTFNTPNLKYLNLSYNAHISLSKNFMGLENLESLDLQHTILKDHDKYPAFYSLINLRYLDISYTNTHVKFKNIFTGMSNLKHLKMAGSSFQDNILHDIFKNLTKLVSLNISYCQLERVSQETMSPLHQLQVLDLSHNKLQTFDPFICMPLLNLQVLNCSSNSITALNGENLQELSRTLISIDLSDNPFDCVCDHQIFFQWVKEHTHLLNRSKPMTCQTPSHMKDISVQLFDDSTCHMKKTVIAVSLLGIIVILLVLALVYKFYFHLMLLAGCKNIGGGESIYDAFVIYSSQDEDWVRKELVKNLEEGVPSFQLCLHYRDFIPGVAIAANIIQEGFHKSRKVIVVISEHFIQSRWCKFEYEIAQTWQFLSSQAGIIFIILQKVEKSLLRQQMELYRLLNRNTYLEWEDTNLGRHVFWRRLRKALLDGRTKNPKGAAEEEFSQPVSPT

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

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