F6XVN0 · F6XVN0_MACMU
- ProteinSorbitol dehydrogenase
- GeneSORD
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids357 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Polyol dehydrogenase that catalyzes the reversible NAD+-dependent oxidation of various sugar alcohols. Is active with D-sorbitol (D-glucitol) leading to the C2-oxidized product D-fructose. Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility.
Catalytic activity
- H+ + keto-D-fructose + NADH = D-sorbitol + NAD+
Cofactor
Note: Binds 1 or 2 Zn2+ ions per subunit.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | extracellular exosome | |
Cellular Component | mitochondrial membrane | |
Cellular Component | motile cilium | |
Molecular Function | D-sorbitol dehydrogenase (acceptor) activity | |
Molecular Function | D-xylulose reductase activity | |
Molecular Function | identical protein binding | |
Molecular Function | L-iditol 2-dehydrogenase (NAD+) activity | |
Molecular Function | NAD binding | |
Molecular Function | zinc ion binding | |
Biological Process | flagellated sperm motility | |
Biological Process | fructose biosynthetic process | |
Biological Process | glucuronate catabolic process to xylulose 5-phosphate | |
Biological Process | L-xylitol catabolic process | |
Biological Process | sorbitol catabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSorbitol dehydrogenase
- EC number
- Short namesSDH ; XDH
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Cercopithecinae > Macaca
Accessions
- Primary accessionF6XVN0
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion membrane ; Peripheral membrane protein
Note: Associated with mitochondria of the midpiece and near the plasma membrane in the principal piece of the flagellum. Also found in the epididymosome, secreted by the epididymal epithelium and that transfers proteins from the epididymal fluid to the sperm surface.
Keywords
- Cellular component
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 16-348 | Enoyl reductase (ER) | ||||
Sequence: GPGDLRLENYPIPEPGPNEVLLRMHSVGICGSDVHYWEEGRIGNFIVKKPMVLGHEASGTVEKVGSLVKHLKPGDRVAIEPGVPRENDEFCKSGRYNLSPSIFFCATPPDDGNLCRFYKHNAAFCYKLPDNVTFEEGALIEPLSVGIHACRRGGVTLGHRVLVCGAGPIGVVSLLVAKAMGAAQVVVTDLSAPRLSKAKEIGADLVLQISKESPQEIAGKVEGLLGCKPEVTIECTGAEASIQAGIYATRSGGTLVLVGLGSEMTTIPLLHAAVREVDIKGVFRYCNTWPVAISMLASKSVNIKPLVTHRFPLEKALEAFETFKKGLGLKIML |
Sequence similarities
Belongs to the zinc-containing alcohol dehydrogenase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length357
- Mass (Da)38,206
- Last updated2011-07-27 v1
- Checksum4BB2278B107274CD
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JU323287 EMBL· GenBank· DDBJ | AFE67043.1 EMBL· GenBank· DDBJ | mRNA | ||
JU476912 EMBL· GenBank· DDBJ | AFH33716.1 EMBL· GenBank· DDBJ | mRNA |