F6WXR7 · F6WXR7_MONDO
- ProteinAngiotensin-converting enzyme
- GeneACE2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids806 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- angiotensin I + H2O = angiotensin-(1-9) + L-leucineThis reaction proceeds in the forward direction.
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 zinc ion per subunit.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 375 | Proton acceptor 1 | ||||
Sequence: E | ||||||
Active site | 375 | Proton acceptor 2 | ||||
Sequence: E | ||||||
Active site | 505 | Proton donor 1 | ||||
Sequence: H | ||||||
Active site | 505 | Proton donor 2 | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | apical plasma membrane | |
Cellular Component | brush border membrane | |
Cellular Component | cell surface | |
Cellular Component | cilium | |
Cellular Component | cytoplasm | |
Cellular Component | extracellular space | |
Cellular Component | plasma membrane | |
Molecular Function | carboxypeptidase activity | |
Molecular Function | endopeptidase activity | |
Molecular Function | identical protein binding | |
Molecular Function | metal ion binding | |
Molecular Function | metallopeptidase activity | |
Molecular Function | peptidyl-dipeptidase activity | |
Molecular Function | virus receptor activity | |
Biological Process | angiotensin-mediated drinking behavior | |
Biological Process | entry receptor-mediated virion attachment to host cell | |
Biological Process | positive regulation of cardiac muscle contraction | |
Biological Process | positive regulation of gap junction assembly | |
Biological Process | positive regulation of L-proline import across plasma membrane | |
Biological Process | proteolysis | |
Biological Process | regulation of cardiac conduction | |
Biological Process | tryptophan transport |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameAngiotensin-converting enzyme
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Metatheria > Didelphimorphia > Didelphidae > Monodelphis
Accessions
- Primary accessionF6WXR7
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 738-761 | Helical | ||||
Sequence: VTVWMIVFGVVMGIVVIGIVYLIY |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, glycosylation, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-17 | |||||
Sequence: MLDPLWLFFSLLAVTAA | ||||||
Chain | PRO_5003350054 | 18-806 | Angiotensin-converting enzyme | |||
Sequence: QNSIEEDAKTFLDDYNAKAEELSHQSALASWEYNTNITNENVEKMNEAAARWSSFYENQSSISRTYPLNEITNATVKLQLKSLQKKEGAVLSTEQSVRLNTILNTMSTLYSTGSVCNSETPQQCFLLEPGLDKIMDESTDYDERLWAWEGWRSKVGKEMRPLYEEYVELKNELAKGNNYEDYGDYWRGDYEVEEPSEYVYSRPQLKKDVENTFKQIKSLYEHLHAYVRRKMRNTYGSLISETGGLPAHLLGDMWGRFWTNLYSLTMPYREKPNIDVTSAMKKQNWSARRIFQEAEMFFASVGLPNMTEGFWKNSMLTEPNDGRKVVCHPTAWDLGKNDFRIKMCTKVTMDDFLTAHHEMGHIQYDMAYAKQPFTLRNGANEGFHEAVGEIMSLSAATPKHLQALGLLPPTFQEDNETEINFLFKQALTIIGTMPFTYMLENWRWMVFEGKIPKEEWMKKWWEMKREIVGVVEPLPHDETYCDPAALFHVANDYSFIRYYTRTIYQFQFHKALCKIAQPSAALHKCDITNSTEAGTKLQNMLKMGKSEPWTKALESIVGNKMMDAGPLLEYFEPLFTWLKEQNKDAYVGWNTDWSPYNAYKIKVRISLKTLGENAYTWNENEMYLFQSSIVFAMRQYFLIKKKQSIPFSNENVKMFDLKPRISFYFFVTFPPNGTSFVPREEVEAAISMSRDRINDAFRLNDNSLEFVGISPTLAPPYEPPVTVWMIVFGVVMGIVVIGIVYLIYTGVRDRKKRAKTSSSNDENPYVDVDVAGGQHNPAFQSSEDAQTSF | ||||||
Glycosylation | 53 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 90 | N-linked (GlcNAc...) (complex) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 133↔141 | |||||
Sequence: CNSETPQQC | ||||||
Disulfide bond | 344↔361 | |||||
Sequence: CHPTAWDLGKNDFRIKMC | ||||||
Disulfide bond | 530↔542 | |||||
Sequence: CKIAQPSAALHKC |
Keywords
- PTM
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 614-806 | Collectrin-like | ||||
Sequence: NAYKIKVRISLKTLGENAYTWNENEMYLFQSSIVFAMRQYFLIKKKQSIPFSNENVKMFDLKPRISFYFFVTFPPNGTSFVPREEVEAAISMSRDRINDAFRLNDNSLEFVGISPTLAPPYEPPVTVWMIVFGVVMGIVVIGIVYLIYTGVRDRKKRAKTSSSNDENPYVDVDVAGGQHNPAFQSSEDAQTSF | ||||||
Region | 770-806 | Disordered | ||||
Sequence: RAKTSSSNDENPYVDVDVAGGQHNPAFQSSEDAQTSF | ||||||
Compositional bias | 792-806 | Polar residues | ||||
Sequence: HNPAFQSSEDAQTSF |
Sequence similarities
Belongs to the peptidase M2 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length806
- Mass (Da)93,226
- Last updated2013-01-09 v2
- Checksum7D61BF46C235FC11
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 792-806 | Polar residues | ||||
Sequence: HNPAFQSSEDAQTSF |
Keywords
- Technical term