F6WXR7 · F6WXR7_MONDO

Function

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.
chloride (UniProtKB | Rhea| CHEBI:17996 )

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site375Proton acceptor 1
Active site375Proton acceptor 2
Active site505Proton donor 1
Active site505Proton donor 2

GO annotations

AspectTerm
Cellular Componentapical plasma membrane
Cellular Componentbrush border membrane
Cellular Componentcell surface
Cellular Componentcilium
Cellular Componentcytoplasm
Cellular Componentextracellular space
Cellular Componentplasma membrane
Molecular Functioncarboxypeptidase activity
Molecular Functionendopeptidase activity
Molecular Functionidentical protein binding
Molecular Functionmetal ion binding
Molecular Functionmetallopeptidase activity
Molecular Functionpeptidyl-dipeptidase activity
Molecular Functionvirus receptor activity
Biological Processangiotensin-mediated drinking behavior
Biological Processentry receptor-mediated virion attachment to host cell
Biological Processpositive regulation of cardiac muscle contraction
Biological Processpositive regulation of gap junction assembly
Biological Processpositive regulation of L-proline import across plasma membrane
Biological Processproteolysis
Biological Processregulation of cardiac conduction
Biological Processtryptophan transport

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Angiotensin-converting enzyme
  • EC number

Gene names

    • Name
      ACE2

Organism names

Accessions

  • Primary accession
    F6WXR7

Proteomes

Subcellular Location

Apical cell membrane
Cell membrane
Cell projection, cilium
Cytoplasm
Membrane
; Single-pass type I membrane protein
Secreted

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane738-761Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain, glycosylation, disulfide bond.

TypeIDPosition(s)Description
Signal1-17
ChainPRO_500335005418-806Angiotensin-converting enzyme
Glycosylation53N-linked (GlcNAc...) asparagine
Glycosylation90N-linked (GlcNAc...) (complex) asparagine
Disulfide bond133↔141
Disulfide bond344↔361
Disulfide bond530↔542

Keywords

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain614-806Collectrin-like
Region770-806Disordered
Compositional bias792-806Polar residues

Sequence similarities

Belongs to the peptidase M2 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    806
  • Mass (Da)
    93,226
  • Last updated
    2013-01-09 v2
  • Checksum
    7D61BF46C235FC11
MLDPLWLFFSLLAVTAAQNSIEEDAKTFLDDYNAKAEELSHQSALASWEYNTNITNENVEKMNEAAARWSSFYENQSSISRTYPLNEITNATVKLQLKSLQKKEGAVLSTEQSVRLNTILNTMSTLYSTGSVCNSETPQQCFLLEPGLDKIMDESTDYDERLWAWEGWRSKVGKEMRPLYEEYVELKNELAKGNNYEDYGDYWRGDYEVEEPSEYVYSRPQLKKDVENTFKQIKSLYEHLHAYVRRKMRNTYGSLISETGGLPAHLLGDMWGRFWTNLYSLTMPYREKPNIDVTSAMKKQNWSARRIFQEAEMFFASVGLPNMTEGFWKNSMLTEPNDGRKVVCHPTAWDLGKNDFRIKMCTKVTMDDFLTAHHEMGHIQYDMAYAKQPFTLRNGANEGFHEAVGEIMSLSAATPKHLQALGLLPPTFQEDNETEINFLFKQALTIIGTMPFTYMLENWRWMVFEGKIPKEEWMKKWWEMKREIVGVVEPLPHDETYCDPAALFHVANDYSFIRYYTRTIYQFQFHKALCKIAQPSAALHKCDITNSTEAGTKLQNMLKMGKSEPWTKALESIVGNKMMDAGPLLEYFEPLFTWLKEQNKDAYVGWNTDWSPYNAYKIKVRISLKTLGENAYTWNENEMYLFQSSIVFAMRQYFLIKKKQSIPFSNENVKMFDLKPRISFYFFVTFPPNGTSFVPREEVEAAISMSRDRINDAFRLNDNSLEFVGISPTLAPPYEPPVTVWMIVFGVVMGIVVIGIVYLIYTGVRDRKKRAKTSSSNDENPYVDVDVAGGQHNPAFQSSEDAQTSF

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias792-806Polar residues

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

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