F6WT52 · F6WT52_MONDO

Function

Catalytic activity

Features

Showing features for binding site, active site, site.

1959100200300400500600700800900
TypeIDPosition(s)Description
Binding site565Mg2+ (UniProtKB | ChEBI)
Binding site592-600ATP (UniProtKB | ChEBI)
Binding site593-600ATP (UniProtKB | ChEBI)
Binding site620ATP (UniProtKB | ChEBI)
Binding site668-674ATP (UniProtKB | ChEBI)
Active site774Proton acceptor
Binding site778ATP (UniProtKB | ChEBI)
Binding site779Mg2+ (UniProtKB | ChEBI)
Binding site792Mg2+ (UniProtKB | ChEBI)
Site919Important for interaction with phosphotyrosine-binding proteins

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell surface
Cellular ComponentCSF1-CSF1R complex
Cellular Componentnucleoplasm
Cellular Componentplasma membrane
Cellular Componentreceptor complex
Molecular FunctionATP binding
Molecular Functioncytokine binding
Molecular Functiongrowth factor binding
Molecular Functionmacrophage colony-stimulating factor receptor activity
Molecular Functionmetal ion binding
Molecular Functionprotein homodimerization activity
Molecular Functionprotein phosphatase binding
Biological Processaxon guidance
Biological Processcell surface receptor protein tyrosine kinase signaling pathway
Biological Processcell-cell junction maintenance
Biological Processforebrain neuron differentiation
Biological Processmicroglial cell proliferation
Biological Processnegative regulation of apoptotic process
Biological Processnegative regulation of cell population proliferation
Biological Processolfactory bulb development
Biological Processosteoclast differentiation
Biological Processpositive regulation by host of viral process
Biological Processpositive regulation of cell migration
Biological Processpositive regulation of chemokine production
Biological Processpositive regulation of ERK1 and ERK2 cascade
Biological Processpositive regulation of macrophage chemotaxis
Biological Processpositive regulation of macrophage proliferation
Biological Processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Biological Processpositive regulation of tyrosine phosphorylation of STAT protein
Biological Processregulation of actin cytoskeleton organization
Biological Processregulation of cell shape
Biological Processregulation of MAPK cascade
Biological Processresponse to ischemia
Biological Processruffle organization

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    receptor protein-tyrosine kinase
  • EC number

Gene names

    • Name
      CSF1R

Organism names

Accessions

  • Primary accession
    F6WT52

Proteomes

Subcellular Location

Membrane
; Single-pass type I membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane518-542Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

TypeIDPosition(s)Description
Signal1-19
ChainPRO_500334475820-959receptor protein-tyrosine kinase
Disulfide bond42↔87
Disulfide bond134↔182
Disulfide bond229↔285
Disulfide bond424↔489

Keywords

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, compositional bias, region.

TypeIDPosition(s)Description
Domain21-105Ig-like
Domain208-296Ig-like
Domain407-507Ig-like
Domain586-906Protein kinase
Compositional bias917-931Polar residues
Region917-940Disordered

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    959
  • Mass (Da)
    108,132
  • Last updated
    2013-01-09 v2
  • Checksum
    AA679AF26FC2CEA5
MAPGILIPLMAVVVWHSQATPMIEPSGPNLVVERGSTITLRCEGNANVDWVSDVNLHTNGWIQDTMGNLSTLSIINSTISHTGTYQCLEKGEENSNGDNSTASLHLYVKDPENLWSVPHSEVTAEEDSDVLLPCRITDPTAEPWVSLEHSYGKPFRSHYTFDSRKGITIQKVQFIHRGDYRCKTVVGGKSKYSSKISLIVDKVLLGPPKLWLEPSELVQIQGEPVQIICRATNPDVHFDLVFKHQQKETSYLNKYDYNSNDDVYQNTINFTIPAVGPEDGGTYFCNASNPKGYNISFTVLKVVEHGYVNLSSEQSLRLEMDVGKDLVLMVSVETYPTMLHWNWTYDGPFLNSQRSLPNSISETTYRFNTTLPLSRLKESEAGYYTFHAENSDAKASLSFEVILNYPPEVQVQQAEFNISNVLRCIAFGYPAPEIMWYRCSGKEERCNQDRVLLWRDINASVVSQEPFHKVKVESMLHIQTLMENTTYMCMASNKVGNNSHSFWPILTKPSFQPERDSLFTPILMVCISIMVVLSLLLLLLLYKYKQKPKYQVRWKIIEACEGNNYIFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCHYGDLLNFLRRKAEDMLVPTLSAEPDGGPGYRNVHLEKKYMHGQGLDTYVEMRPVSSSSSGSFSEQELDQEDGRPLELCDLLRFSSQVAQGMAFLASKNCIHRDVAARNVLVTSRRVAKIGDFGLARDIMNDTNYVVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLSPYPGILVNSKFYKLVKEGYQMAQPNFSPPNIYSIMQACWDLEPTRRPTFQQICSFLQEEMDATSKKQDYANLPSSGSSEEEDSVSEPLDCCDQVDSSQPLLQANNYQFC

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias917-931Polar residues

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

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