F6WT52 · F6WT52_MONDO
- Proteinreceptor protein-tyrosine kinase
- GeneCSF1R
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids959 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- ATP + L-tyrosyl-[protein] = ADP + H+ + O-phospho-L-tyrosyl-[protein]
Features
Showing features for binding site, active site, site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 565 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 592-600 | ATP (UniProtKB | ChEBI) | ||||
Sequence: LGAGAFGKV | ||||||
Binding site | 593-600 | ATP (UniProtKB | ChEBI) | ||||
Sequence: GAGAFGKV | ||||||
Binding site | 620 | ATP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 668-674 | ATP (UniProtKB | ChEBI) | ||||
Sequence: EYCHYGD | ||||||
Active site | 774 | Proton acceptor | ||||
Sequence: D | ||||||
Binding site | 778 | ATP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 779 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 792 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Site | 919 | Important for interaction with phosphotyrosine-binding proteins | ||||
Sequence: Y |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namereceptor protein-tyrosine kinase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Metatheria > Didelphimorphia > Didelphidae > Monodelphis
Accessions
- Primary accessionF6WT52
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 518-542 | Helical | ||||
Sequence: LFTPILMVCISIMVVLSLLLLLLLY |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-19 | |||||
Sequence: MAPGILIPLMAVVVWHSQA | ||||||
Chain | PRO_5003344758 | 20-959 | receptor protein-tyrosine kinase | |||
Sequence: TPMIEPSGPNLVVERGSTITLRCEGNANVDWVSDVNLHTNGWIQDTMGNLSTLSIINSTISHTGTYQCLEKGEENSNGDNSTASLHLYVKDPENLWSVPHSEVTAEEDSDVLLPCRITDPTAEPWVSLEHSYGKPFRSHYTFDSRKGITIQKVQFIHRGDYRCKTVVGGKSKYSSKISLIVDKVLLGPPKLWLEPSELVQIQGEPVQIICRATNPDVHFDLVFKHQQKETSYLNKYDYNSNDDVYQNTINFTIPAVGPEDGGTYFCNASNPKGYNISFTVLKVVEHGYVNLSSEQSLRLEMDVGKDLVLMVSVETYPTMLHWNWTYDGPFLNSQRSLPNSISETTYRFNTTLPLSRLKESEAGYYTFHAENSDAKASLSFEVILNYPPEVQVQQAEFNISNVLRCIAFGYPAPEIMWYRCSGKEERCNQDRVLLWRDINASVVSQEPFHKVKVESMLHIQTLMENTTYMCMASNKVGNNSHSFWPILTKPSFQPERDSLFTPILMVCISIMVVLSLLLLLLLYKYKQKPKYQVRWKIIEACEGNNYIFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCHYGDLLNFLRRKAEDMLVPTLSAEPDGGPGYRNVHLEKKYMHGQGLDTYVEMRPVSSSSSGSFSEQELDQEDGRPLELCDLLRFSSQVAQGMAFLASKNCIHRDVAARNVLVTSRRVAKIGDFGLARDIMNDTNYVVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLSPYPGILVNSKFYKLVKEGYQMAQPNFSPPNIYSIMQACWDLEPTRRPTFQQICSFLQEEMDATSKKQDYANLPSSGSSEEEDSVSEPLDCCDQVDSSQPLLQANNYQFC | ||||||
Disulfide bond | 42↔87 | |||||
Sequence: CEGNANVDWVSDVNLHTNGWIQDTMGNLSTLSIINSTISHTGTYQC | ||||||
Disulfide bond | 134↔182 | |||||
Sequence: CRITDPTAEPWVSLEHSYGKPFRSHYTFDSRKGITIQKVQFIHRGDYRC | ||||||
Disulfide bond | 229↔285 | |||||
Sequence: CRATNPDVHFDLVFKHQQKETSYLNKYDYNSNDDVYQNTINFTIPAVGPEDGGTYFC | ||||||
Disulfide bond | 424↔489 | |||||
Sequence: CIAFGYPAPEIMWYRCSGKEERCNQDRVLLWRDINASVVSQEPFHKVKVESMLHIQTLMENTTYMC |
Keywords
- PTM
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 21-105 | Ig-like | ||||
Sequence: PMIEPSGPNLVVERGSTITLRCEGNANVDWVSDVNLHTNGWIQDTMGNLSTLSIINSTISHTGTYQCLEKGEENSNGDNSTASLH | ||||||
Domain | 208-296 | Ig-like | ||||
Sequence: PKLWLEPSELVQIQGEPVQIICRATNPDVHFDLVFKHQQKETSYLNKYDYNSNDDVYQNTINFTIPAVGPEDGGTYFCNASNPKGYNIS | ||||||
Domain | 407-507 | Ig-like | ||||
Sequence: PEVQVQQAEFNISNVLRCIAFGYPAPEIMWYRCSGKEERCNQDRVLLWRDINASVVSQEPFHKVKVESMLHIQTLMENTTYMCMASNKVGNNSHSFWPILT | ||||||
Domain | 586-906 | Protein kinase | ||||
Sequence: LQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCHYGDLLNFLRRKAEDMLVPTLSAEPDGGPGYRNVHLEKKYMHGQGLDTYVEMRPVSSSSSGSFSEQELDQEDGRPLELCDLLRFSSQVAQGMAFLASKNCIHRDVAARNVLVTSRRVAKIGDFGLARDIMNDTNYVVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLSPYPGILVNSKFYKLVKEGYQMAQPNFSPPNIYSIMQACWDLEPTRRPTFQQICSFL | ||||||
Compositional bias | 917-931 | Polar residues | ||||
Sequence: QDYANLPSSGSSEEE | ||||||
Region | 917-940 | Disordered | ||||
Sequence: QDYANLPSSGSSEEEDSVSEPLDC |
Sequence similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length959
- Mass (Da)108,132
- Last updated2013-01-09 v2
- ChecksumAA679AF26FC2CEA5
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 917-931 | Polar residues | ||||
Sequence: QDYANLPSSGSSEEE |
Keywords
- Technical term