F6VX93 · F6VX93_HUMAN
- ProteinVPS53 subunit of GARP complex
- GeneVPS53
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids547 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score1/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | GARP complex | |
Biological Process | retrograde transport, endosome to Golgi |
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Organism
- Taxonomic lineagecellular organisms > Eukaryota (eucaryotes) > Opisthokonta > Metazoa (metazoans) > Eumetazoa > Bilateria > Deuterostomia > Chordata (chordates) > Craniata > Vertebrata (vertebrates) > Gnathostomata (jawed vertebrates) > Teleostomi > Euteleostomi (bony vertebrates) > Sarcopterygii > Dipnotetrapodomorpha > Tetrapoda (tetrapods) > Amniota (amniotes) > Mammalia (mammals) > Theria > Eutheria (placentals) > Boreoeutheria > Euarchontoglires > Primates > Haplorrhini > Simiiformes > Catarrhini > Hominoidea (apes) > Hominidae (great apes) > Homininae > Homo
Accessions
- Primary accessionF6VX93
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 934 variants from UniProt as well as other sources including ClinVar and dbSNP.
Genetic variation databases
PTM/Processing
Features
Showing features for modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Modified residue (large scale data) | 329 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 333 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 343 | PRIDE | Phosphothreonine | ||||
Sequence: T |
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, coiled coil, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 41-227 | Vps53 N-terminal | ||||
Sequence: DFNAVEYINTLFPTEQSLANIDEVVNKIRLKIRRLDDNIRTVVRGQTNVGQDGRQALEEAQKAIQQLFGKIKDIKDKAEKSEQMVKEITRDIKQLDHAKRHLTTSITTLNHLHMLAGGVDSLEAMTRRRQYGEVANLLQGVMNVLEHFHKYMGIPQIRQLSERVKAAQTELGQQILADFEEAFPSQG | ||||||
Coiled coil | 97-138 | |||||
Sequence: LEEAQKAIQQLFGKIKDIKDKAEKSEQMVKEITRDIKQLDHA | ||||||
Domain | 228-403 | Vps53 N-terminal | ||||
Sequence: TKVAWLDKIDRRYAWIKRQLVDYEEKYGRMFPREWCMAERIAVEFCHVTRAELAKIMRTRAKEIEVKLLLFAIQRTTNFEGFLAKRFSGCTLTDGTLKKLESPPPSTNPFLEDEPTPEMEELATEKGDLDQPKKPKAPDNPFHGIVSKCFEPHLYVYIESQDKNLGELIDRFVADF | ||||||
Region | 324-364 | Disordered | ||||
Sequence: LKKLESPPPSTNPFLEDEPTPEMEELATEKGDLDQPKKPKA | ||||||
Compositional bias | 347-364 | Basic and acidic residues | ||||
Sequence: EELATEKGDLDQPKKPKA |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length547
- Mass (Da)62,167
- Last updated2011-07-27 v1
- Checksum86C32EF00395070B
Computationally mapped potential isoform sequences
There are 45 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q5VIR6 | VPS53_HUMAN | VPS53 | 832 | ||
E7EVT8 | E7EVT8_HUMAN | VPS53 | 422 | ||
A0A7P0T9V8 | A0A7P0T9V8_HUMAN | VPS53 | 644 | ||
A0A7P0T9Z7 | A0A7P0T9Z7_HUMAN | VPS53 | 136 | ||
A0A7P0T9X9 | A0A7P0T9X9_HUMAN | VPS53 | 135 | ||
A0A7P0T8D0 | A0A7P0T8D0_HUMAN | VPS53 | 109 | ||
A0A7P0T8A9 | A0A7P0T8A9_HUMAN | VPS53 | 51 | ||
A0A7P0T8I9 | A0A7P0T8I9_HUMAN | VPS53 | 117 | ||
A0A7P0T8K1 | A0A7P0T8K1_HUMAN | VPS53 | 119 | ||
A0A7P0T8P7 | A0A7P0T8P7_HUMAN | VPS53 | 680 | ||
A0A7P0T8S5 | A0A7P0T8S5_HUMAN | VPS53 | 109 | ||
A0A7P0T8V1 | A0A7P0T8V1_HUMAN | VPS53 | 464 | ||
A0A7P0T8V2 | A0A7P0T8V2_HUMAN | VPS53 | 97 | ||
A0A7P0T8V9 | A0A7P0T8V9_HUMAN | VPS53 | 106 | ||
A0A7P0T9B2 | A0A7P0T9B2_HUMAN | VPS53 | 782 | ||
A0A7P0T9B6 | A0A7P0T9B6_HUMAN | VPS53 | 166 | ||
A0A7P0T804 | A0A7P0T804_HUMAN | VPS53 | 78 | ||
A0A7P0T805 | A0A7P0T805_HUMAN | VPS53 | 253 | ||
A0A7P0T874 | A0A7P0T874_HUMAN | VPS53 | 673 | ||
A0A7P0T7U9 | A0A7P0T7U9_HUMAN | VPS53 | 133 | ||
A0A7P0T8A5 | A0A7P0T8A5_HUMAN | VPS53 | 233 | ||
A0A7P0TB80 | A0A7P0TB80_HUMAN | VPS53 | 422 | ||
A0A7P0TBG3 | A0A7P0TBG3_HUMAN | VPS53 | 83 | ||
A0A7P0TBJ8 | A0A7P0TBJ8_HUMAN | VPS53 | 216 | ||
A0A7P0TBK3 | A0A7P0TBK3_HUMAN | VPS53 | 237 | ||
A0A7P0TA41 | A0A7P0TA41_HUMAN | VPS53 | 133 | ||
A0A7P0TA53 | A0A7P0TA53_HUMAN | VPS53 | 242 | ||
A0A7P0TA79 | A0A7P0TA79_HUMAN | VPS53 | 546 | ||
A0A7P0TA82 | A0A7P0TA82_HUMAN | VPS53 | 80 | ||
A0A7P0TAE0 | A0A7P0TAE0_HUMAN | VPS53 | 655 | ||
A0A7P0TAF8 | A0A7P0TAF8_HUMAN | VPS53 | 293 | ||
A0A7P0TAK4 | A0A7P0TAK4_HUMAN | VPS53 | 631 | ||
A0A7P0TB16 | A0A7P0TB16_HUMAN | VPS53 | 372 | ||
A0A7P0Z4K0 | A0A7P0Z4K0_HUMAN | VPS53 | 572 | ||
A0A7P0Z4M8 | A0A7P0Z4M8_HUMAN | VPS53 | 104 | ||
A0A7P0Z4Q7 | A0A7P0Z4Q7_HUMAN | VPS53 | 337 | ||
A0A7P0Z400 | A0A7P0Z400_HUMAN | VPS53 | 709 | ||
A0A7P0Z461 | A0A7P0Z461_HUMAN | VPS53 | 643 | ||
I3L4P9 | I3L4P9_HUMAN | VPS53 | 203 | ||
I3L1W6 | I3L1W6_HUMAN | VPS53 | 81 | ||
I3L184 | I3L184_HUMAN | VPS53 | 342 | ||
I3L0S6 | I3L0S6_HUMAN | VPS53 | 216 | ||
A0AAG2TC49 | A0AAG2TC49_HUMAN | VPS53 | 68 | ||
A0AAG2TFL7 | A0AAG2TFL7_HUMAN | VPS53 | 237 | ||
A0AAG2TET0 | A0AAG2TET0_HUMAN | VPS53 | 145 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 347-364 | Basic and acidic residues | ||||
Sequence: EELATEKGDLDQPKKPKA |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC015853 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC027455 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
KC877627 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
KC877635 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |