Data suggest that alcohol/ethanol exposure diminishes pool of proliferative neurons (Neuro2a cell line) through disordering of spindle orientation and promotion of asymmetric cell division; these neuronal abnormalities appear to be due to reduced CENPJ protein expression level.
Data suggest that the single G-box domain (that appears to fold into 14-20 antiparallel beta-strands) of CENPJ has stable but dynamic structure; CRAP forms multimers (in solution and in crystals) of elongated fibrils similar to amyloid fibrils. (review)
Centrobin-CPAP interaction is critical for the recruitment of CPAP to procentrioles to promote the elongation of daughter centrioles and for the persistence of CPAP on preexisting mother centrioles.
The results showed a human-specific hypomethylation in the 5' UTR of CENPJ in the brain where methylation levels among humans are only about one-third of those found among nonhuman primates.
studies provide the first structural insight into how the malfunction of centriole proteins results in human disease and also reveal that the CPAP-STIL interaction constitutes a conserved key step in centriole biogenesis
CEP120 associates with SPICE1 and CPAP and depletion of any of these proteins results in short procentrioles. Furthermore CEP120 or CPAP overexpression results in excessive centriole elongation a process dependent on CEP120 SPICE1 and CPAP.
Authors propose that CEP135 directly connects the central hub protein hSAS-6 to the outer microtubules and suggest that this interaction stabilizes the proper cartwheel structure for further CPAP-mediated centriole elongation.
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