F6V6I0 · UBP13_XENTR

Function

function

Deubiquitinase that mediates deubiquitination of target proteins and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD).

Catalytic activity

  • Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
    EC:3.4.19.12 (UniProtKB | ENZYME | Rhea)

Activity regulation

Specifically inhibited by spautin-1 (specific and potent autophagy inhibitor-1), a derivative of MBCQ that binds to usp13 and inhibits deubiquitinase activity.

Features

Showing features for binding site, active site.

1846100200300400500600700800
TypeIDPosition(s)Description
Binding site192Zn2+ (UniProtKB | ChEBI)
Binding site195Zn2+ (UniProtKB | ChEBI)
Binding site212Zn2+ (UniProtKB | ChEBI)
Binding site225Zn2+ (UniProtKB | ChEBI)
Active site806Proton acceptor

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular Functioncysteine-type deubiquitinase activity
Molecular Functioncysteine-type endopeptidase activity
Molecular Functionubiquitin binding
Molecular Functionzinc ion binding
Biological Processautophagy
Biological Processcell population proliferation
Biological Processprotein K63-linked deubiquitination
Biological Processprotein stabilization
Biological Processproteolysis
Biological Processregulation of autophagy
Biological Processregulation of DNA-templated transcription

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ubiquitin carboxyl-terminal hydrolase 13
  • EC number
  • Alternative names
    • Deubiquitinating enzyme 13
    • Ubiquitin thioesterase 13
    • Ubiquitin-specific-processing protease 13

Gene names

    • Name
      usp13

Organism names

Accessions

  • Primary accession
    F6V6I0

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004180141-846Ubiquitin carboxyl-terminal hydrolase 13

Proteomic databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for zinc finger, domain.

TypeIDPosition(s)Description
Zinc finger168-276UBP-type; degenerate
Domain317-844USP
Domain633-676UBA 1
Domain708-748UBA 2

Domain

The UBP-type zinc finger has lost its ability to bind ubiquitin and usp13 is not activated by unanchored ubiquitin.
The UBA domains mediate binding to ubiquitin.

Sequence similarities

Belongs to the peptidase C19 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    846
  • Mass (Da)
    95,089
  • Last updated
    2012-06-13 v2
  • Checksum
    139B256C047BE39A
MAEDLGELLVPYMPTIRVPKSGDRVYKTECAFSYDSPESDGGLYVCMSTFLGFGREHVERHYRKTGQSVYMHLKRHIRLKATGASGGAFPKRINGRLFLDLENNTEMNTEDYEYEDEAKLVIFPDHFEIALPNIEELPALVTIACDAVLNSKSPYRKLDQESWEEELQVSKFANNLVQIDNGVKIPPSGWKCSKCDLQENLWLNLTDGSIMCGRWFCSGSGGNGHALEHHKQMGYPLAVRLGSITPDGADVYSFDEEEAVIDPHLAKHLAHFGIDMLQMQGSENGVLDNEVKPRVNEWEVIQETGLKLKPMFGSGYTGIKNLGNSSYLTTVMQVIFSIPEFQRAYVGNLTRIFDYAPLDPTQDFSTQMAKLGHGLLSGQFSKPPMKSELIEQVMKEEHKPQPKGINTRMFKALMSKGHTEFSSNRQQDAEEFFLHFINLVERNSIGAENPSDVFRFLVEERTQCCQSRKVRYTERVDYIMQLPVPMETATNKEELIAYDLKRREAESAKRPPPELVRAKIPFSACLQAFTEPENVPDFWSSALQAKSAGVKTSRFASFPEYLVVQIKKFTFGLDWVPKKLDVSIDMPDLLDINHLRATGLKSGEEELPDIAPPIIIPDDPNGRMAESLLSGSGSNVNSSFKGAQPLNLPFGKKEAKLLRYMERMVEKFGFKFSVRLSVEIDFAEPLIIPGCGTVTSTSSHGQNALLNQPPEEIVALICSMGFPRNHALQALRATNNNLERALDWMFSHPESEEGADNVSGCVDTENNPNGIITDSEQEGPRIKDGNGRYELFGIISHAGTSTMSGHYVCHIKKEGRWVIYNDHKVSASERPPKELGYIYFYHRISC

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8J0QHL3A0A8J0QHL3_XENTRusp13846
A0A8J0QKT1A0A8J0QKT1_XENTRusp13844

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAMC01001929
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AAMC01001930
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AAMC01001931
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AAMC01001932
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AAMC01001933
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AAMC01001934
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

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Disclaimer

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