F6V226 · F6V226_MONDO

Function

function

Catalyzes several different glutathione-dependent reactions. Catalyzes the glutathione-dependent reduction of lipid hydroperoxides, such as 5-HPETE. Has glutathione transferase activity, toward xenobiotic electrophiles, such as 1-chloro-2, 4-dinitrobenzene (CDNB). Catalyzes also the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4 (LTC4). Involved in oxidative DNA damage induced by ER stress and anticancer agents by activating LTC4 biosynthetic machinery in nonimmune cells.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functionenzyme activator activity
Molecular Functionglutathione binding
Molecular Functionglutathione peroxidase activity
Molecular Functionglutathione transferase activity
Molecular Functionlyase activity
Biological Processleukotriene biosynthetic process
Biological Processlipid metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Microsomal glutathione S-transferase 2
  • EC number
  • Short names
    Microsomal GST-2
    ; Microsomal GST-II
  • Alternative names
    • Glutathione peroxidase MGST2
    • Leukotriene C4 synthase MGST2
    • Microsomal glutathione S-transferase II

Gene names

    • Name
      MGST2

Organism names

Accessions

  • Primary accession
    F6V226

Proteomes

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein
Microsome membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane67-89Helical
Transmembrane110-131Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-19
ChainPRO_500334354620-145Microsomal glutathione S-transferase 2

Expression

Gene expression databases

Interaction

Subunit

Homotrimer.

Family & Domains

Sequence similarities

Belongs to the MAPEG family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    145
  • Mass (Da)
    16,702
  • Last updated
    2013-01-09 v2
  • Checksum
    0804FFF5F21E0C1A
MASHLVLLAAVSVLSVCQQSFFAWQVGKARLKYKISPPAITGSPAFERIFRAQQNCVEFYPIFLITFWMAGWFFNQVLAAILGLAYMYARHHFFFGYSESAKQRLFGFRMSLGVLALLIIQAVVGIGYELWDEYMDLKFFKKLVF

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A5F8HKF6A0A5F8HKF6_MONDOMGST2164

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

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