F6V226 · F6V226_MONDO
- ProteinMicrosomal glutathione S-transferase 2
- GeneMGST2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids145 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes several different glutathione-dependent reactions. Catalyzes the glutathione-dependent reduction of lipid hydroperoxides, such as 5-HPETE. Has glutathione transferase activity, toward xenobiotic electrophiles, such as 1-chloro-2, 4-dinitrobenzene (CDNB). Catalyzes also the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4 (LTC4). Involved in oxidative DNA damage induced by ER stress and anticancer agents by activating LTC4 biosynthetic machinery in nonimmune cells.
Catalytic activity
- (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | enzyme activator activity | |
Molecular Function | glutathione binding | |
Molecular Function | glutathione peroxidase activity | |
Molecular Function | glutathione transferase activity | |
Molecular Function | lyase activity | |
Biological Process | leukotriene biosynthetic process | |
Biological Process | lipid metabolic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMicrosomal glutathione S-transferase 2
- EC number
- Short namesMicrosomal GST-2 ; Microsomal GST-II
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Metatheria > Didelphimorphia > Didelphidae > Monodelphis
Accessions
- Primary accessionF6V226
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Microsome membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 67-89 | Helical | |||
Transmembrane | 110-131 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-19 | ||||
Chain | PRO_5003343546 | 20-145 | Microsomal glutathione S-transferase 2 | ||
Expression
Gene expression databases
Interaction
Subunit
Homotrimer.
Structure
Sequence
- Sequence statusComplete
- Length145
- Mass (Da)16,702
- Last updated2013-01-09 v2
- Checksum0804FFF5F21E0C1A
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A5F8HKF6 | A0A5F8HKF6_MONDO | MGST2 | 164 |
Keywords
- Technical term