F6V0D3 · F6V0D3_MONDO

Function

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell surface
Cellular Componentextracellular space
Molecular FunctionBMP binding
Molecular Functioncytokine activity
Molecular Functionprotein homodimerization activity
Molecular Functionreceptor ligand activity
Molecular Functiontransmembrane receptor protein tyrosine kinase activator activity
Molecular Functionvascular endothelial growth factor receptor 2 binding
Biological Processanimal organ morphogenesis
Biological Processcardiac muscle cell differentiation
Biological Processcardiac muscle cell myoblast differentiation
Biological Processcell migration involved in sprouting angiogenesis
Biological Processcell morphogenesis
Biological Processcell-cell signaling
Biological Processcollagen fibril organization
Biological Processdetermination of dorsal identity
Biological Processembryonic limb morphogenesis
Biological Processmesenchymal to epithelial transition involved in metanephros morphogenesis
Biological Processnegative regulation of apoptotic process
Biological Processnegative regulation of bone mineralization involved in bone maturation
Biological Processnegative regulation of bone remodeling
Biological Processnegative regulation of bone trabecula formation
Biological Processnegative regulation of canonical Wnt signaling pathway
Biological Processnegative regulation of chondrocyte differentiation
Biological Processnegative regulation of DNA-templated transcription
Biological Processnegative regulation of osteoblast differentiation
Biological Processnegative regulation of osteoblast proliferation
Biological Processnegative regulation of osteoclast proliferation
Biological Processnegative regulation of SMAD protein signal transduction
Biological Processpositive regulation of angiogenesis
Biological Processpositive regulation of branching involved in ureteric bud morphogenesis
Biological Processpositive regulation of cell population proliferation
Biological Processpositive regulation of non-canonical NF-kappaB signal transduction
Biological Processpositive regulation of peptidyl-tyrosine autophosphorylation
Biological Processpositive regulation of protein tyrosine kinase activity
Biological Processpositive regulation of receptor internalization
Biological Processpositive regulation of signaling receptor activity
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processproximal/distal pattern formation
Biological Processregulation of epithelial to mesenchymal transition
Biological Processregulation of focal adhesion assembly
Biological Processsequestering of BMP from receptor via BMP binding
Biological Processureteric bud formation

Keywords

  • Molecular function

Names & Taxonomy

Protein names

  • Recommended name
    Gremlin

Gene names

    • Name
      GREM1

Organism names

Accessions

  • Primary accession
    F6V0D3

Proteomes

Subcellular Location

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

Type
IDPosition(s)Description
Signal1-24
ChainPRO_500515339525-184Gremlin
Disulfide bond94↔144
Disulfide bond108↔158
Disulfide bond118↔176
Disulfide bond122↔178

Keywords

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region24-77Disordered
Compositional bias40-59Polar residues
Domain96-183CTCK

Sequence similarities

Belongs to the DAN family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    184
  • Mass (Da)
    20,771
  • Last updated
    2011-07-27 v1
  • Checksum
    CAD7128B604A4517
MGRTAYTVGALLLLLGTLLSATEGKKKGSQGAIPPPDKDQYNDSEQTQTPQQPGSRNRGRGQGRGTAMPGEEVLESSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCISIDLD

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias40-59Polar residues

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

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