F6U9W6 · F6U9W6_HORSE

  • Protein
    Tyrosine-protein phosphatase non-receptor type
  • Gene
    PTPN6
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

Catalytic activity

Features

Showing features for binding site, active site.

159750100150200250300350400450500550
Type
IDPosition(s)Description
Binding site421substrate
Active site455Phosphocysteine intermediate
Binding site502substrate

GO annotations

AspectTerm
Cellular Componentalpha-beta T cell receptor complex
Cellular Componentcell-cell junction
Cellular Componentcytoplasm
Cellular Componentnucleolus
Cellular Componentnucleoplasm
Molecular Functioncell adhesion molecule binding
Molecular Functionphosphorylation-dependent protein binding
Molecular Functionphosphotyrosine residue binding
Molecular Functionprotein kinase binding
Molecular FunctionSH2 domain binding
Molecular FunctionSH3 domain binding
Molecular Functiontransmembrane receptor protein tyrosine phosphatase activity
Biological ProcessB cell receptor signaling pathway
Biological ProcessCD27 signaling pathway
Biological Processepididymis development
Biological Processhematopoietic progenitor cell differentiation
Biological ProcessMAPK cascade
Biological Processmegakaryocyte development
Biological Processnatural killer cell mediated cytotoxicity
Biological Processnegative regulation of angiogenesis
Biological Processnegative regulation of B cell receptor signaling pathway
Biological Processnegative regulation of humoral immune response mediated by circulating immunoglobulin
Biological Processnegative regulation of inflammatory response to wounding
Biological Processnegative regulation of innate immune response
Biological Processnegative regulation of interleukin-6 production
Biological Processnegative regulation of MAPK cascade
Biological Processnegative regulation of mast cell activation involved in immune response
Biological Processnegative regulation of peptidyl-tyrosine phosphorylation
Biological Processnegative regulation of T cell proliferation
Biological Processnegative regulation of T cell receptor signaling pathway
Biological Processnegative regulation of tumor necrosis factor production
Biological Processpeptidyl-tyrosine dephosphorylation
Biological Processpeptidyl-tyrosine phosphorylation
Biological Processplatelet aggregation
Biological Processplatelet formation
Biological Processpositive regulation of cell adhesion mediated by integrin
Biological Processpositive regulation of cell population proliferation
Biological Processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Biological Processregulation of B cell differentiation
Biological Processregulation of ERK1 and ERK2 cascade
Biological Processregulation of G1/S transition of mitotic cell cycle
Biological Processregulation of release of sequestered calcium ion into cytosol
Biological ProcessT cell proliferation
Biological ProcessT cell receptor signaling pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Tyrosine-protein phosphatase non-receptor type
  • EC number

Gene names

    • Name
      PTPN6

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Thoroughbred
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Perissodactyla > Equidae > Equus

Accessions

  • Primary accession
    F6U9W6

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Expression

Gene expression databases

Structure

3D structure databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain6-102SH2
Domain112-215SH2
Domain246-517Tyrosine-protein phosphatase
Domain432-508Tyrosine specific protein phosphatases
Region533-597Disordered
Compositional bias556-591Basic and acidic residues

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    597
  • Mass (Da)
    67,624
  • Last updated
    2023-09-13 v2
  • Checksum
    B32406A210D25901
MLSCGWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGGSETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKSKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYVKNQLLGPDENAKTYIASQGCLEATVNDFWQMVWQENTRVIVMTTREVEKGRNKCVPYWPEVGSQRVYGPYAVTNCGEHDTAEYKLRTLHVSPLDNGDLVREIWHYQYLSWPDHGVPSEPGGVLSFLDRINQQQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMESISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVMQSQKGRESEYGNITYPPAMKNAHSKASRTSSKHKEDVYENVHTKNKKEEKVKKQRSADKEKSKGSLKRK

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A5F5PWB4A0A5F5PWB4_HORSEPTPN6558

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias556-591Basic and acidic residues

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

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